Ancestry Publications

Alvin Cengnata, C Pei-Mei, Tham T et al.

Annals of human geneticsAnn Hum GenetDissecting the Genetic Affinity Between the Orang Asli and Southeast Asian Native Populations.1121-1210.1111/ahg.70005Southeast Asia (SEA) is a region with enriched human diversity and complex population history. Despite numerous small-scale population genetics studies being carried out, the map of human migration in this landmass remains fragmentary. Notably, the genetic affinities of the Orang Asli from Peninsular Malaysia and other SEA natives have not been comprehensively assessed.In this study, publicly available genotypic datasets were gathered and imputed. The genetic relationships and ancestry make-up of 19 SEA native populations, covering Peninsular Malaysia, Indonesia, Papua New Guinea, the Philippines, Vietnam, and Andaman, were comprehended and benchmarked with 14 global populations.With ∼20 million SNPs coverage, we provided supporting evidence to (i) a possible ancient genetic link between the Andamanese, Papuan and the Philippines and Peninsular Negrito; (ii) gene flow from the ancestors of Andamanese to Papuan, and the Negrito from Peninsular Malaysia and the Philippines; (iii) different genetic structures between the island SEA (iSEA) and mainland (mSEA) populations; (iv) close genetic affinity between the Proto-Malay Seletar with the iSEA populations and (v) close genetic affinity between the Senoi Mah Meri with the Proto-Malays.To our knowledge, this study reported the highest genomic sequence coverage and the most comprehensive SEA native populations covered thus far. Our results not only have provided strong supporting evidence to the earlier hypothesis, but also novel insights into the genetic diversity of the SEA native populations.© 2025 University College London (UCL) and John Wiley & Sons Ltd.AlvinCengnataCFaculty of Applied Sciences, UCSI University, Kuala Lumpur, Malaysia.Pei-MeiThamTDivision of Applied Biomedical Sciences and Biotechnology, School of Health Sciences, IMU University, Kuala Lumpur, Malaysia.Hoi-ThungFooFDivision of Applied Biomedical Sciences and Biotechnology, School of Health Sciences, IMU University, Kuala Lumpur, Malaysia.Calista Zhe-QingChanCDivision of Applied Biomedical Sciences and Biotechnology, School of Health Sciences, IMU University, Kuala Lumpur, Malaysia.XinLeeLDivision of Applied Biomedical Sciences and Biotechnology, School of Health Sciences, IMU University, Kuala Lumpur, Malaysia.Renee Lay-HongLimLFaculty of Applied Sciences, UCSI University, Kuala Lumpur, Malaysia.LianDengDState Key Laboratory of Genetic Engineering, Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Center for Evolutionary Biology, School of Life Sciences, Fudan University, Shanghai, China.ShuhuaXuXState Key Laboratory of Genetic Engineering, Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Center for Evolutionary Biology, School of Life Sciences, Fudan University, Shanghai, China.Department of Liver Surgery and Transplantation Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China.Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, Fudan University, Shanghai, China.School of Life Science and Technology, ShanghaiTech University, Shanghai, China.Boon-PengHohHDivision of Applied Biomedical Sciences and Biotechnology, School of Health Sciences, IMU University, Kuala Lumpur, Malaysia.engFRGS/1/2021/STG01/UCSI/01/1Ministry of Higher Education (MOHE) Malaysia32030020National Natural Science Foundation of China32288101National Natural Science Foundation of China32270665National Natural Science Foundation of ChinaJournal Article20250629EnglandAnn Hum Genet04166610003-4800Orang Asli peopleIMHumansAsia, SoutheasternGene FlowGenetic VariationGenetics, PopulationHuman MigrationMalaysiaPolymorphism, Single NucleotideSoutheast Asian PeopleOrang AsliSoutheast Asiagenetic affinitygenome variationsnatives2025662025111202561120251212720202571462025630233ppublish4058339610.1111/ahg.70005References

Meriam Guellil, Lucy van Dorp, Lehti Saag et al.

Science advances

World

Youyang Qu, Zhanrui Zhao, Chao Ning et al.

Archaeological and Anthropological Sciences

China

Andy Walton, William Marsh, Alex Strang et al.

Journal of Archaeological Science

Great-Britain

Casas-Vargas Andrea, A Guzmán, Alejandra Coronel AC et al.

American journal of human biology : the official journal of the Human Biology CouncilAm J Hum BiolGenetic Structure of the Y-Chromosome in Colombia: An Analysis of Regional Diversity and Ancestry.e70171e7017110.1002/ajhb.70171To determine the genetic diversity and ancestry of male lineages across various regions of Colombia by analyzing Y-chromosome Short Tandem Repeats (STRs) and to explore how these genetic variations relate to the historical and migratory events that shaped the country's subpopulations.A total of 672 DNA samples from diverse Colombian populations were analyzed, and Y-chromosome STRs were genotyped using the Yfiler and Yfiler Plus amplification kits. Haplogroup assignments were performed using open-source software, and multivariate analyses were employed to facilitate intra- and interpopulation comparisons.Substantial genetic diversity was observed among the haplotypes of the studied populations. Haplogroup R1b, of European origin, was predominant in the Andean region, while haplogroup E1b, associated with African ancestry, was more frequent in the Pacific and San Andrés regions. In relatively conserved populations, such as those from the Amazon and La Guajira, a high frequency of haplogroup Q, characteristic of Native American lineages, was detected. Multidimensional scaling (MDS) analyses showed clear genetic separations among regions, reflecting historical and geographical influences. Populations from the Pacific and Caribbean coasts clustered closely with African lineages, while those from the interior of the country exhibited a stronger European influence. In contrast, Indigenous communities and other more conserved populations, such as those in the Amazon, were clearly differentiated, underscoring the preservation of native lineages.The results highlight the genetic complexity of Colombian populations, which have been shaped by the admixture of Native American, African, European, and, to a lesser extent, Middle Eastern lineages. These findings highlight the impact of historical processes, including European colonization, the transatlantic slave trade, and more recent migration events, on the country's genetic structure.© 2025 Wiley Periodicals LLC.Casas-VargasAndreaAGrupo de Genética de Poblaciones e Identificación, Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia.GuzmánAlejandra CoronelACGrupo de Genética de Poblaciones e Identificación, Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia.AvilaAngie JAJGrupo de Genética de Poblaciones e Identificación, Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia.Albarracin-BarreraJulyJGrupo de Genética de Poblaciones e Identificación, Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia.Aponte-RubioYuryYGrupo de Genética de Poblaciones e Identificación, Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia.SuárezDayanaDGrupo de Genética de Poblaciones e Identificación, Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia.Moncada MaderoJulieJGrupo de Genética de Poblaciones e Identificación, Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia.MogollónFernandaFGrupo de Genética de Poblaciones e Identificación, Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia.BravoNora ContrerasNCSchool of Medicine and Health Sciences, Center for Research in Genetics and Genomics (CIGGUR), Institute of Translational Medicine (IMT), Universidad del Rosario, Bogotá DC, Colombia.MorelAdrienASchool of Medicine and Health Sciences, Center for Research in Genetics and Genomics (CIGGUR), Institute of Translational Medicine (IMT), Universidad del Rosario, Bogotá DC, Colombia.CabreraRodrigoRSchool of Medicine and Health Sciences, Center for Research in Genetics and Genomics (CIGGUR), Institute of Translational Medicine (IMT), Universidad del Rosario, Bogotá DC, Colombia.Fonseca-MendozaDora JanethDJSchool of Medicine and Health Sciences, Center for Research in Genetics and Genomics (CIGGUR), Institute of Translational Medicine (IMT), Universidad del Rosario, Bogotá DC, Colombia.BernalIngrid TatyanaITUniversidad Nacional de Colombia, Bogotá, Colombia.RestrepoCarlos MCMSchool of Medicine and Health Sciences, Center for Research in Genetics and Genomics (CIGGUR), Institute of Translational Medicine (IMT), Universidad del Rosario, Bogotá DC, Colombia.Sánchez-GómezYasmínYUniversidad de Boyacá, Medisens S.A.S, Tunja, Boyacá, Colombia.Usaquén-MartínezWilliamW0000-0001-5409-7125Grupo de Genética de Poblaciones e Identificación, Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia.engMinisterio de Ciencia, Tecnología e InnovaciónDirección de Investigación, Universidad Nacional de ColombiaMinciencias632-2021Minciencias, Project in Health promoting personalized Medicine and Translational ResearchQAN BG273Universidad del RosarioJournal ArticleUnited StatesAm J Hum Biol89150291042-0533IMHumansColombiaChromosomes, Human, YgeneticsMaleGenetic VariationHaplotypesMicrosatellite RepeatsColombiaSouth AmericaY‐STRsY‐chromosomegenetic diversitypopulation genetics2025916202521820251112202512273820251227372025122343ppublish4132802010.1002/ajhb.70171References

Panxin Du, Yu Xu, Xiaoli Zhang et al.

Journal of Archaeological Science: Reports

South Asia

Francesca Gandini, Mafalda Almeida, M George B Foody et al.

Science Advances

Sahul

Ran Jingkun, J Liu, Yichen Y et al.

iScience

Anna Tommasi, Rajiv Boscolo Agostini, Giacomo Villani et al.

Science advances

Sicily

Anne-France Maurer, Rebecca MacRoberts, Judith Margarita López-Aceves et al.

Archaeological and Anthropological Sciences

Portugal

Daxuan Zhang, Bing Sun, Fajun Li et al.

Science Bulletin

China

Esha Bandyopadhyay, David Witonsky, Constanza de la Fuente Castro et al.

Science Advances

Nepal