Genetic Predisposition
Based on your genetic markers, your predisposition to this trait is shown below
Your Result
Higher Bunions susceptibility predisposition
Was this result accurate for you?
Scientific Evidence
Understanding the Data
- SNP: A specific genetic marker relevant to this trait (e.g., rs2588978)
- Genotype: Your genetic makeup at the given SNP location (e.g., CC)
- Variant allele: The alternative DNA sequence at the SNP site
- Variant allele frequency: Percentage of population carrying this variant
- Variant found: Whether the variant was detected in your DNA file
AC007682.1 GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs141161671 | -- | G | A | 1.00% | No Data |
| rs6733149 | -- | A | C | 1.00% | No Data |
AC019330.1 GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs140676665 | -- | G | A | 99.00% | No Data |
ACTG1P9 GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs113871023 | -- | A | T | 99.00% | No Data |
ANKFN1 GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs117155606 | -- | C | T | 1.00% | No Data |
ARHGEF1 GeneCards
Rho guanine nucleotide exchange factor 1
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs539720802 | -- | G | T | 99.00% | No Data |
CLCA2 GeneCards
chloride channel accessory 2
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs55807512 | -- | T | C | 4.00% | No Data |
COL24A1 GeneCards
This gene is a member of the collagen gene family and is thought to regulate type I collagen fibrillogenesis during fetal development.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs12143200 | -- | T | G | 3.00% | No Data |
DPYS GeneCards
Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs150013648 | -- | C | T | 2.00% | No Data |
DSCAM GeneCards
DS cell adhesion molecule
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs191124187 | -- | G | C | 1.00% | No Data |
DSN1 GeneCards
DSN1 component of MIS12 kinetochore complex
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs80177909 | -- | A | G | 98.00% | No Data |
EYS GeneCards
The product of this gene contains multiple epidermal growth factor (EGF)-like and LamG domains. The protein is expressed in the photoreceptor layer of the retina, and the gene is mutated in autosomal recessive retinitis pigmentosa. Multiple transcript variants encoding different isoforms have been found for this gene.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs116712252 | -- | G | A | 99.00% | No Data |
GRIN2A GeneCards
This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without cognitive disability. Alternative splicing results in multiple transcript variants.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs188650377 | -- | A | T | 1.00% | No Data |
L3MBTL4 GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs77993129 | -- | T | C | 97.00% | No Data |
LINC00448 GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs140687271 | -- | C | A | 99.00% | No Data |
LINC00540 GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs76655016 | -- | T | A | 1.00% | No Data |
LINC02074 GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs11868764 | -- | A | G | 3.00% | No Data |
MTR GeneCards
This gene encodes the 5-methyltetrahydrofolate-homocysteine methyltransferase. This enzyme, also known as cobalamin-dependent methionine synthase, catalyzes the final step in methionine biosynthesis. Mutations in MTR have been identified as the underlying cause of methylcobalamin deficiency complementation group G. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs72762109 | -- | A | G | 1.00% | No Data |
MYO1B GeneCards
myosin IB
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs145025296 | -- | T | C | 2.00% | No Data |
| rs139705512 | -- | G | A | 2.00% | No Data |
ODF2L GeneCards
outer dense fiber of sperm tails 2 like
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs146496015 | -- | G | T | 6.00% | No Data |
OPCML GeneCards
This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins. The encoded preprotein is proteolytically processed to generate the mature protein. This protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs117974989 | -- | G | A | 99.00% | No Data |
RFLNA GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs142973841 | -- | C | T | 2.00% | No Data |
RFLNA GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs142973841 | -- | C | T | 2.00% | No Data |
RNU6-1213P GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs28395286 | -- | C | T | 5.00% | No Data |
SLC8A1-AS1 GeneCards
SLC8A1 antisense RNA 1
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs10176968 | -- | G | A | 39.00% | No Data |
SLIT3 GeneCards
The protein encoded by this gene is secreted, likely interacting with roundabout homolog receptors to effect cell migration. Two transcript variants encoding different isoforms have been found for this gene.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs74863661 | -- | C | T | 15.00% | No Data |
SOX2-OT GeneCards
SOX2 overlapping transcript
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs11707593 | -- | C | T | 24.00% | No Data |
WASF3 GeneCards
WASP family member 3
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs71218579 | -- | A | A | 68.00% | No Data |
WDR27 GeneCards
This gene encodes a protein with multiple WD repeats. Proteins with these repeats may form scaffolds for protein-protein interaction and play key roles in cell signalling. Alternative splicing results in multiple transcript variants, but the full-length structure of some of these variants cannot be determined.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs3891969 | -- | G | A | 15.00% | No Data |
These are the genetic markers (SNPs) analyzed for this trait. Variations detected in your genome are listed under the "Genotype" column. SNPs showing "--" were not identified in your DNA file.
| SNP | Chromosome | Genotype | Variant Allele | Frequency |
|---|---|---|---|---|
| rs347133 | 3 | GA | A | 26.00% |
| rs4811981 | 20 | CT | T | 30.00% |
| rs146496015 | 1 | -- | T | 6.00% |
| chr18:50130115 | -- | A | 2.00% | |
| chr8:52512282 | -- | G | 1.00% | |
| rs72762109 | 1 | -- | G | 1.00% |
| rs55807512 | 1 | -- | C | 4.00% |
| rs12143200 | 1 | -- | G | 3.00% |
| rs145025296 | 2 | -- | C | 2.00% |
| rs141161671 | 2 | -- | A | 1.00% |
| rs12619631 | 2 | -- | A | 15.00% |
| rs140676665 | 2 | -- | A | 99.00% |
| rs6733149 | 2 | -- | C | 1.00% |
| rs10176968 | 2 | -- | A | 39.00% |
| rs139705512 | 2 | -- | A | 2.00% |
| rs11707593 | 3 | -- | T | 24.00% |
| rs9850315 | 3 | -- | C | 2.00% |
| rs13147821 | 4 | -- | A | 26.00% |
| rs58302722 | 4 | -- | A | 2.00% |
| rs11728629 | 4 | -- | A | 24.00% |
| rs74863661 | 5 | -- | T | 15.00% |
| rs116783165 | 5 | -- | C | 3.00% |
| rs3891969 | 6 | -- | A | 15.00% |
| rs78762426 | 6 | -- | A | 8.00% |
| rs113871023 | 6 | -- | T | 99.00% |
| rs116712252 | 6 | -- | A | 99.00% |
| rs1859504 | 7 | -- | C | 32.00% |
| rs28395286 | 8 | -- | T | 5.00% |
| rs150013648 | 8 | -- | T | 2.00% |
| rs2631419 | 11 | -- | T | 32.00% |
| rs117974989 | 11 | -- | A | 99.00% |
| rs142973841 | 12 | -- | T | 2.00% |
| rs76655016 | 13 | -- | A | 1.00% |
| rs140687271 | 13 | -- | A | 99.00% |
| rs71218579 | 13 | -- | A | 68.00% |
| rs12888772 | 14 | -- | T | 18.00% |
| rs188650377 | 16 | -- | T | 1.00% |
| rs117155606 | 17 | -- | T | 1.00% |
| rs11868764 | 17 | -- | G | 3.00% |
| rs77993129 | 18 | -- | C | 97.00% |
| rs539720802 | 19 | -- | T | 99.00% |
| rs80177909 | 20 | -- | G | 98.00% |
| rs191124187 | 21 | -- | C | 1.00% |
| rs79147928 | 22 | -- | A | 86.00% |
The following peer-reviewed scientific studies support the genetic associations analyzed in this report.
What's Next?
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