Genome-wide meta-analysis identified novel variant associated with hallux valgus in Caucasians.
Arbeeva L, Yau M, Mitchell BD et al.
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Abstract
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Hallux valgus, one of the most common structural foot deformities, is highly heritable. However, previous efforts to elucidate the genetic underpinnings of hallux valgus through a genome-wide association study (GWAS) conducted in 4409 Caucasians did not identify genome-wide significant associations with hallux valgus in both gender-specific and sex-combined GWAS meta-analyses. In this analysis, we add newly available data and more densely imputed genotypes to identify novel genetic variants associated with hallux valgus.
609 European ancestry male cases, 1,666 European ancestry male controls
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