Active: Aortic valve stenosis Clear all

GWAS 2024-03-18

Integrative genomic analyses identify candidate causal genes for calcific aortic valve stenosis involving tissue-specific regulation.

Thériault S, Li Z et al.

Nat Commun

There is currently no medical therapy to prevent calcific aortic valve stenosis (CAVS). Multi-omics ...

Calcific aortic valve stenosis

956682

Participants

N/A

Studies

Details PubMed

GWAS 2023-02-20

Multiancestry Genome-Wide Association Study of Aortic Stenosis Identifies Multiple Novel Loci in the Million Veteran Program.

Small AM, Peloso GM et al.

Circulation

Calcific aortic stenosis (CAS) is the most common valvular heart disease in older adults and has no ...

Calcific aortic valve stenosis

Replicated

566454

Participants

N/A

Studies

Details PubMed

GWAS 2020-03-18

Association of FADS1/2 Locus Variants and Polyunsaturated Fatty Acids With Aortic Stenosis.

Chen HY, Cairns BJ et al.

JAMA Cardiol

Importance: Aortic stenosis (AS) has no approved medical treatment. Identifying etiological pathways...

Aortic valve stenosis

Replicated

312118

Participants

N/A

Studies

Details PubMed

GWAS 2019-10-15

Genetic Association Analyses Highlight IL6, ALPL, and NAV1 As 3 New Susceptibility Genes Underlying Calcific Aortic Valve Stenosis.

Thériault S, Dina C et al.

Circ Genom Precis Med

Calcific aortic valve stenosis (CAVS) is a frequent and life-threatening cardiovascular disease for ...

Calcific aortic valve stenosis

359187

Participants

N/A

Studies

Details PubMed

GWAS 2019-08-07

Defects in the Exocyst-Cilia Machinery Cause Bicuspid Aortic Valve Disease and Aortic Stenosis.

Fulmer D, Toomer K et al.

Circulation

Bicuspid aortic valve (BAV) disease is a congenital defect that affects 0.5% to 1.2% of the populati...

Bicuspid aortic valve

Replicated

4859

Participants

N/A

Studies

Details PubMed

GWAS 2018-03-07

A transcriptome-wide association study identifies PALMD as a susceptibility gene for calcific aortic valve stenosis.

Thériault S, Gaudreault N et al.

Nat Commun

Calcific aortic valve stenosis (CAVS) is a common and life-threatening heart disease and the current...

Calcific aortic valve stenosis

Replicated

355612

Participants

N/A

Studies

Details PubMed

GWAS 2018-03-07

Genome-wide analysis yields new loci associating with aortic valve stenosis.

Helgadottir A, Thorleifsson G et al.

Nat Commun

Aortic valve stenosis (AS) is the most common valvular heart disease, and valve replacement is the o...

Aortic valve stenosis

Replicated

808380

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Integrative genomic analyses identify candidate causal genes for calcific aortic valve stenosis involving tissue-specific regulation.

Thériault S, Li Z et al.

Nat Commun

Calcific aortic valve stenosis

2024-03-18

Multiancestry Genome-Wide Association Study of Aortic Stenosis Identifies Multiple Novel Loci in the Million Veteran Program.

Small AM, Peloso GM et al.

Circulation

Calcific aortic valve stenosis

2023-02-20

Association of FADS1/2 Locus Variants and Polyunsaturated Fatty Acids With Aortic Stenosis.

Chen HY, Cairns BJ et al.

JAMA Cardiol

Aortic valve stenosis

2020-03-18

Genetic Association Analyses Highlight IL6, ALPL, and NAV1 As 3 New Susceptibility Genes Underlying Calcific Aortic Valve Stenosis.

Thériault S, Dina C et al.

Circ Genom Precis Med

Calcific aortic valve stenosis

2019-10-15

Defects in the Exocyst-Cilia Machinery Cause Bicuspid Aortic Valve Disease and Aortic Stenosis.

Fulmer D, Toomer K et al.

Circulation

Bicuspid aortic valve

2019-08-07

A transcriptome-wide association study identifies PALMD as a susceptibility gene for calcific aortic valve stenosis.

Thériault S, Gaudreault N et al.

Nat Commun

Calcific aortic valve stenosis

2018-03-07

Genome-wide analysis yields new loci associating with aortic valve stenosis.

Helgadottir A, Thorleifsson G et al.

Nat Commun

Aortic valve stenosis

2018-03-07