Active: Bilirubin levels Clear all

GWAS 2024-08-30

Genome-wide analyses of neonatal jaundice reveal a marked departure from adult bilirubin metabolism.

Solé-Navais P, Juodakis J et al.

Nat Commun

Jaundice affects almost all neonates in their first days of life and is caused by the accumulation o...

Neonatal jaundice (maternal effect)

Replicated

31583

Participants

N/A

Studies

Details PubMed

GWAS 2024-05-17

Genetic determinants of serum bilirubin using inferred native American gene variants in Chilean adolescents.

Miranda JP, Pereira A et al.

Front Genet

Gene variants in the UGT1A1 gene are strongly associated with circulating bilirubin levels in severa...

Total bilirubin levels

707

Participants

N/A

Studies

Details PubMed

GWAS 2023-11-20

Deep learning-based phenotype imputation on population-scale biobank data increases genetic discoveries.

An U, Pazokitoroudi A et al.

Nat Genet

Biobanks that collect deep phenotypic and genomic data across many individuals have emerged as a key...

Direct bilirubin levels (UKB data field 30660)

285405

Participants

N/A

Studies

Details PubMed

GWAS 2022-07-09

Variance-quantitative trait loci enable systematic discovery of gene-environment interactions for cardiometabolic serum biomarkers.

Westerman KE, Majarian TD et al.

Nat Commun

Gene-environment interactions represent the modification of genetic effects by environmental exposur...

Direct bilirubin levels

Replicated

5694

Participants

N/A

Studies

Details PubMed

GWAS 2022-02-11

UGT1A1 genetic variants are associated with increases in bilirubin levels in rheumatoid arthritis patients treated with sarilumab.

Lin N, Damask A et al.

Pharmacogenomics J

Sarilumab is a human monoclonal antibody against interleukin (IL)-6Rα that has been approved for the...

Bilirubin levels in sarilumab-treated rheumatoid arthritis patients

755

Participants

N/A

Studies

Details PubMed

GWAS 2021-07-01

Insomnia affects the levels of plasma bilirubin and protein metabolism: an observational study and GWGEIS in UK Biobank cohort.

Chu X, Liu L et al.

Sleep Med

Study objectives: We aim to explore the mechanism of relationship between insomnia and liver metabol...

Direct bilirubin levels x insomnia interaction

159854

Participants

N/A

Studies

Details PubMed

GWAS 2021-06-11

A UGT1A1 variant is associated with serum total bilirubin levels, which are causal for hypertension in African-ancestry individuals.

Chen G, Adeyemo A et al.

NPJ Genom Med

Serum bilirubin is associated with several clinical outcomes, including hypertension, type 2 diabete...

Total bilirubin levels

1127

Participants

N/A

Studies

Details PubMed

GWAS 2020-02-21

A genome-wide association study on liver enzymes in Korean population.

Seo JY, Lee JE et al.

PLoS One

Although genetic features vary across ethnicities, few genome-wide association studies (GWAS) have r...

Bilirubin levels

Replicated

6488

Participants

N/A

Studies

Details PubMed

GWAS 2019-12-05

Causal Associations Between Serum Bilirubin Levels and Decreased Stroke Risk: A Two-Sample Mendelian Randomization Study.

Choi Y, Lee SJ et al.

Arterioscler Thromb Vasc Biol

Objective: A number of epidemiological studies have reported that decreased serum bilirubin, an endo...

Bilirubin levels

25406

Participants

N/A

Studies

Details PubMed

GWAS 2019-07-12

Bilirubin and risk of ischemic heart disease in Korea: A two-sample Mendelian randomization study.

Jeon C, Lee JY et al.

Epidemiol Health

Objectives: Bilirubin is an endogenous antioxidant that protects cells against oxidative stress. Inc...

Ischemic heart disease

13855

Participants

N/A

Studies

Details PubMed

GWAS 2019-01-04

Genome-Wide Association Study (GWAS) on Bilirubin Concentrations in Subjects with Metabolic Syndrome: Sex-Specific GWAS Analysis and Gene-Diet Interactions in a Mediterranean Population.

Coltell O, Asensio EM et al.

Nutrients

Although, for decades, increased serum bilirubin concentrations were considered a threatening sign o...

Serum bilirubin levels in metabolic syndrome

430

Participants

N/A

Studies

Details PubMed

GWAS 2015-01-09

Phenome-wide Association Study Relating Pretreatment Laboratory Parameters With Human Genetic Variants in AIDS Clinical Trials Group Protocols.

Moore CB, Verma A et al.

Open Forum Infect Dis

Background. Phenome-Wide Association Studies (PheWAS) identify genetic associations across multiple ...

Total bilirubin levels in HIV-1 infection

2547

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genome-wide analyses of neonatal jaundice reveal a marked departure from adult bilirubin metabolism.

Solé-Navais P, Juodakis J et al.

Nat Commun

Neonatal jaundice (maternal effect)

2024-08-30

Genetic determinants of serum bilirubin using inferred native American gene variants in Chilean adolescents.

Miranda JP, Pereira A et al.

Front Genet

Total bilirubin levels

2024-05-17

Deep learning-based phenotype imputation on population-scale biobank data increases genetic discoveries.

An U, Pazokitoroudi A et al.

Nat Genet

Direct bilirubin levels (UKB data field 30660)

2023-11-20

Variance-quantitative trait loci enable systematic discovery of gene-environment interactions for cardiometabolic serum biomarkers.

Westerman KE, Majarian TD et al.

Nat Commun

Direct bilirubin levels

2022-07-09

UGT1A1 genetic variants are associated with increases in bilirubin levels in rheumatoid arthritis patients treated with sarilumab.

Lin N, Damask A et al.

Pharmacogenomics J

Bilirubin levels in sarilumab-treated rheumatoid arthritis patients

2022-02-11

Insomnia affects the levels of plasma bilirubin and protein metabolism: an observational study and GWGEIS in UK Biobank cohort.

Chu X, Liu L et al.

Sleep Med

Direct bilirubin levels x insomnia interaction

2021-07-01

A UGT1A1 variant is associated with serum total bilirubin levels, which are causal for hypertension in African-ancestry individuals.

Chen G, Adeyemo A et al.

NPJ Genom Med

Total bilirubin levels

2021-06-11

A genome-wide association study on liver enzymes in Korean population.

Seo JY, Lee JE et al.

PLoS One

Bilirubin levels

2020-02-21

Causal Associations Between Serum Bilirubin Levels and Decreased Stroke Risk: A Two-Sample Mendelian Randomization Study.

Choi Y, Lee SJ et al.

Arterioscler Thromb Vasc Biol

Bilirubin levels

2019-12-05

Bilirubin and risk of ischemic heart disease in Korea: A two-sample Mendelian randomization study.

Jeon C, Lee JY et al.

Epidemiol Health

Ischemic heart disease

2019-07-12

Genome-Wide Association Study (GWAS) on Bilirubin Concentrations in Subjects with Metabolic Syndrome: Sex-Specific GWAS Analysis and Gene-Diet Interactions in a Mediterranean Population.

Coltell O, Asensio EM et al.

Nutrients

Serum bilirubin levels in metabolic syndrome

2019-01-04

Phenome-wide Association Study Relating Pretreatment Laboratory Parameters With Human Genetic Variants in AIDS Clinical Trials Group Protocols.

Moore CB, Verma A et al.

Open Forum Infect Dis

Total bilirubin levels in HIV-1 infection

2015-01-09