Bilirubin and risk of ischemic heart disease in Korea: A two-sample Mendelian randomization study.
Jeon C, Lee JY, Lee SJ et al.
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Objectives: Bilirubin is an endogenous antioxidant that protects cells against oxidative stress. Increased plasma levels of bilirubin have been associated with a reduced risk of ischemic heart disease (IHD) in previous studies. Nonetheless, whether those associations reflect a true protective effect of bilirubin on IHD, rather than confounding or reverse causation, remains unknown. Therefore, we applied two-sample Mendelian randomization to evaluate the causal association between bilirubin levels and IHD risk in a Korean population.
1,910 Korean ancestry cases, 11,945 Korean ancestry controls
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