Active: Chronic pain Clear all

GWAS 2024-03-01

A multi-ancestry genetic study of pain intensity in 598,339 veterans.

Toikumo S, Vickers-Smith R et al.

Nat Med

Chronic pain is a common problem, with more than one-fifth of adult Americans reporting pain daily o...

Pain intensity (without opioid use disorder)

416740

Participants

N/A

Studies

Details PubMed

GWAS 2023-10-16

Genome wide association joint analysis reveals 99 risk loci for pain susceptibility and pleiotropic relationships with psychiatric, metabolic, and immunological traits.

Mocci E, Ward K et al.

PLoS Genet

Chronic pain is at epidemic proportions in the United States, represents a significant burden on our...

Pain (pleiotropy)

361194

Participants

N/A

Studies

Details PubMed

GWAS 2023-05-23

Genetic risk shared across 24 chronic pain conditions: identification and characterization with genomic structural equation modeling.

Zorina-Lichtenwalter K, Bango CI et al.

Pain

Chronic pain conditions frequently co-occur, suggesting common risks and paths to prevention and tre...

Arthrosis of first carpometacarpal joint

203276

Participants

N/A

Studies

Details PubMed

GWAS 2023-03-16

A genome-wide association study of frailty identifies significant genetic correlation with neuropsychiatric, cardiovascular, and inflammation pathways.

Ye Y, Noche RB et al.

Geroscience

Frailty is an aging-related clinical phenotype defined as a state in which there is an increase in a...

Fried Frailty Score

Replicated

396285

Participants

N/A

Studies

Details PubMed

GWAS 2023-03-13

The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions.

Rahmioglu N, Mortlock S et al.

Nat Genet

Endometriosis is a common condition associated with debilitating pelvic pain and infertility. A geno...

Endometriosis

474160

Participants

N/A

Studies

Details PubMed

GWAS 2022-08-09

Brain-specific genes contribute to chronic but not to acute back pain.

Bortsov AV, Parisien M et al.

Pain Rep

Introduction: Back pain is the leading cause of disability worldwide. Although most back pain cases ...

Chronic back pain

Replicated

423592

Participants

N/A

Studies

Details PubMed

GWAS 2022-03-23

Genotypes of Pain and Analgesia in a Randomized Trial of Irritable Bowel Syndrome.

Vollert J, Wang R et al.

Front Psychiatry

Irritable bowel syndrome (IBS) is a highly prevalent chronic pain disorder with multiple underlying ...

Response to treatment in irritable bowel syndrome (pain frequency)

212

Participants

N/A

Studies

Details PubMed

GWAS 2021-11-02

Genome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry.

Sanchez-Roige S, Fontanillas P et al.

Mol Psychiatry

The growing prevalence of opioid use disorder (OUD) constitutes an urgent health crisis. Ample evide...

Problematic opioid prescription use

132113

Participants

N/A

Studies

Details PubMed

GWAS 2021-04-08

Sex-stratified genome-wide association study of multisite chronic pain in UK Biobank.

Johnston KJA, Ward J et al.

PLoS Genet

Chronic pain is highly prevalent worldwide and imparts a significant socioeconomic and public health...

Multisite chronic pain

178556

Participants

N/A

Studies

Details PubMed

GWAS 2021-01-01

Genome-wide association study identifies candidate loci associated with chronic pain and postherpetic neuralgia.

Nishizawa D, Iseki M et al.

Mol Pain

Human twin studies and other studies have indicated that chronic pain has heritability that ranges f...

Chronic pain

473

Participants

N/A

Studies

Details PubMed

GWAS 2020-09-30

Sex- and age-specific genetic analysis of chronic back pain.

Freidin MB, Tsepilov YA et al.

Pain

Sex differences for chronic back pain (cBP) have been reported, with females usually exhibiting grea...

Chronic back pain

Replicated

245817

Participants

N/A

Studies

Details PubMed

GWAS 2019-11-20

Identification of novel common variants associated with chronic pain using conditional false discovery rate analysis with major depressive disorder and assessment of pleiotropic effects of LRFN5.

Johnston KJA, Adams MJ et al.

Transl Psychiatry

Chronic pain is a complex trait that is moderately heritable and genetically, as well as phenotypica...

Chronic pain or major depressive disorder (pleiotropy)

153851

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

A multi-ancestry genetic study of pain intensity in 598,339 veterans.

Toikumo S, Vickers-Smith R et al.

Nat Med

Pain intensity (without opioid use disorder)

2024-03-01

Genome wide association joint analysis reveals 99 risk loci for pain susceptibility and pleiotropic relationships with psychiatric, metabolic, and immunological traits.

Mocci E, Ward K et al.

PLoS Genet

Pain (pleiotropy)

2023-10-16

Genetic risk shared across 24 chronic pain conditions: identification and characterization with genomic structural equation modeling.

Zorina-Lichtenwalter K, Bango CI et al.

Pain

Arthrosis of first carpometacarpal joint

2023-05-23

A genome-wide association study of frailty identifies significant genetic correlation with neuropsychiatric, cardiovascular, and inflammation pathways.

Ye Y, Noche RB et al.

Geroscience

Fried Frailty Score

2023-03-16

The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions.

Rahmioglu N, Mortlock S et al.

Nat Genet

Endometriosis

2023-03-13

Brain-specific genes contribute to chronic but not to acute back pain.

Bortsov AV, Parisien M et al.

Pain Rep

Chronic back pain

2022-08-09

Genotypes of Pain and Analgesia in a Randomized Trial of Irritable Bowel Syndrome.

Vollert J, Wang R et al.

Front Psychiatry

Response to treatment in irritable bowel syndrome (pain frequency)

2022-03-23

Genome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry.

Sanchez-Roige S, Fontanillas P et al.

Mol Psychiatry

Problematic opioid prescription use

2021-11-02

Sex-stratified genome-wide association study of multisite chronic pain in UK Biobank.

Johnston KJA, Ward J et al.

PLoS Genet

Multisite chronic pain

2021-04-08

Genome-wide association study identifies candidate loci associated with chronic pain and postherpetic neuralgia.

Nishizawa D, Iseki M et al.

Mol Pain

Chronic pain

2021-01-01

Sex- and age-specific genetic analysis of chronic back pain.

Freidin MB, Tsepilov YA et al.

Pain

Chronic back pain

2020-09-30

Identification of novel common variants associated with chronic pain using conditional false discovery rate analysis with major depressive disorder and assessment of pleiotropic effects of LRFN5.

Johnston KJA, Adams MJ et al.

Transl Psychiatry

Chronic pain or major depressive disorder (pleiotropy)

2019-11-20