Genotypes of Pain and Analgesia in a Randomized Trial of Irritable Bowel Syndrome.
Vollert J, Wang R, Regis S et al.
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Abstract
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Irritable bowel syndrome (IBS) is a highly prevalent chronic pain disorder with multiple underlying mechanisms and few treatments that have been demonstrated to be effective in placebo controlled trials. One potential reason may be the use of composite outcomes, such as the IBS Symptom Severity Scale (IBS-SSS) which includes descriptive items related to pain frequency and pain intensity as well as bowel dysfunction and bloating. We investigated if different features of IBS pain have distinct genetic associations and if these may be moderated by sex hormones.
22 European ancestry double-blind peppermint oil-treated individuals, 53 European ancestry double-blind placebo-treated individuals, 52 European ancestry open-label placebo-treated individuals, 52 European ancestry no pill control-treated individuals, 4 double-blind peppermint oil-treated individuals, 9 double-blind placebo-treated individuals, 10 open-label placebo-treated individuals, 10 no pill control-treated individuals
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