Active: Dilated cardiomyopathy Clear all

GWAS 2024-11-21

Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience.

Jurgens SJ, Rämö JT et al.

Nat Genet

Dilated cardiomyopathy (DCM) is a heart muscle disease that represents an important cause of morbidi...

Dilated cardiomyopathy

Replicated

2404278

Participants

N/A

Studies

Details PubMed

GWAS 2024-11-20

Genetic and phenotypic architecture of human myocardial trabeculation.

McGurk KA, Qiao M et al.

Nat Cardiovasc Res

Cardiac trabeculae form a network of muscular strands that line the inner surfaces of the heart. The...

Cardiac trabeculation (Slice 1 FD)

38012

Participants

N/A

Studies

Details PubMed

GWAS 2023-04-26

Druggable proteins influencing cardiac structure and function: Implications for heart failure therapies and cancer cardiotoxicity.

Schmidt AF, Bourfiss M et al.

Sci Adv

Dysfunction of either the right or left ventricle can lead to heart failure (HF) and subsequent morb...

Right ventricular end diastolic volume

35941

Participants

N/A

Studies

Details PubMed

GWAS 2022-06-13

Genome-wide association analysis reveals insights into the genetic architecture of right ventricular structure and function.

Aung N, Vargas JD et al.

Nat Genet

Right ventricular (RV) structure and function influence the morbidity and mortality from coronary ar...

Right ventricular end systolic volume

Replicated

41819

Participants

N/A

Studies

Details PubMed

GWAS 2021-03-03

Genome-wide association analysis in dilated cardiomyopathy reveals two new players in systolic heart failure on chromosomes 3p25.1 and 22q11.23.

Garnier S, Harakalova M et al.

Eur Heart J

Aims: Our objective was to better understand the genetic bases of dilated cardiomyopathy (DCM), a le...

Dilated cardiomyopathy

Replicated

8527

Participants

N/A

Studies

Details PubMed

GWAS 2021-01-25

Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect.

Tadros R, Francis C et al.

Nat Genet

The heart muscle diseases hypertrophic (HCM) and dilated (DCM) cardiomyopathies are leading causes o...

Dilated cardiomyopathy

Replicated

402844

Participants

N/A

Studies

Details PubMed

GWAS 2020-09-02

The Genetic Makeup of the Electrocardiogram.

Verweij N, Benjamins JW et al.

Cell Syst

The electrocardiogram (ECG) is one of the most useful non-invasive diagnostic tests for a wide array...

Electrocardiogram morphology (amplitude at temporal datapoints)

63706

Participants

N/A

Studies

Details PubMed

GWAS 2020-05-07

Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy.

Pirruccello JP, Bick A et al.

Nat Commun

Dilated cardiomyopathy (DCM) is an important cause of heart failure and the leading indication for h...

Left ventricular end-diastolic volume

Replicated

38225

Participants

N/A

Studies

Details PubMed

GWAS 2018-02-26

A Genome-Wide Association Study of Idiopathic Dilated Cardiomyopathy in African Americans.

Xu H, Dorn GW et al.

J Pers Med

Idiopathic dilated cardiomyopathy (IDC) is the most common form of non-ischemic chronic heart failur...

Idiopathic dilated cardiomyopathy

1800

Participants

N/A

Studies

Details PubMed

GWAS 2014-07-17

Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians.

Hong KW, Lim JE et al.

Hum Mol Genet

The electrocardiogram has several advantages in detecting cardiac arrhythmia-it is readily available...

PR interval

Replicated

13380

Participants

N/A

Studies

Details PubMed

GWAS 2013-07-12

A genome-wide association study identifies 6p21 as novel risk locus for dilated cardiomyopathy.

Meder B, Rühle F et al.

Eur Heart J

Aims: Dilated cardiomyopathy (DCM) is one of the leading causes for cardiac transplantations and acc...

Idiopathic dilated cardiomyopathy

Replicated

11853

Participants

N/A

Studies

Details PubMed

GWAS 2013-04-14

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.

den Hoed M, Eijgelsheim M et al.

Nat Genet

Elevated resting heart rate is associated with greater risk of cardiovascular disease and mortality....

Heart rate

Replicated

181178

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience.

Jurgens SJ, Rämö JT et al.

Nat Genet

Dilated cardiomyopathy

2024-11-21

Genetic and phenotypic architecture of human myocardial trabeculation.

McGurk KA, Qiao M et al.

Nat Cardiovasc Res

Cardiac trabeculation (Slice 1 FD)

2024-11-20

Druggable proteins influencing cardiac structure and function: Implications for heart failure therapies and cancer cardiotoxicity.

Schmidt AF, Bourfiss M et al.

Sci Adv

Right ventricular end diastolic volume

2023-04-26

Genome-wide association analysis reveals insights into the genetic architecture of right ventricular structure and function.

Aung N, Vargas JD et al.

Nat Genet

Right ventricular end systolic volume

2022-06-13

Genome-wide association analysis in dilated cardiomyopathy reveals two new players in systolic heart failure on chromosomes 3p25.1 and 22q11.23.

Garnier S, Harakalova M et al.

Eur Heart J

Dilated cardiomyopathy

2021-03-03

Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect.

Tadros R, Francis C et al.

Nat Genet

Dilated cardiomyopathy

2021-01-25

The Genetic Makeup of the Electrocardiogram.

Verweij N, Benjamins JW et al.

Cell Syst

Electrocardiogram morphology (amplitude at temporal datapoints)

2020-09-02

Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy.

Pirruccello JP, Bick A et al.

Nat Commun

Left ventricular end-diastolic volume

2020-05-07

A Genome-Wide Association Study of Idiopathic Dilated Cardiomyopathy in African Americans.

Xu H, Dorn GW et al.

J Pers Med

Idiopathic dilated cardiomyopathy

2018-02-26

Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians.

Hong KW, Lim JE et al.

Hum Mol Genet

PR interval

2014-07-17

A genome-wide association study identifies 6p21 as novel risk locus for dilated cardiomyopathy.

Meder B, Rühle F et al.

Eur Heart J

Idiopathic dilated cardiomyopathy

2013-07-12

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.

den Hoed M, Eijgelsheim M et al.

Nat Genet

Heart rate

2013-04-14