A genome-wide association study identifies 6p21 as novel risk locus for dilated cardiomyopathy.
Meder B, Rühle F, Weis T et al.
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Abstract
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Aims: Dilated cardiomyopathy (DCM) is one of the leading causes for cardiac transplantations and accounts for up to one-third of all heart failure cases. Since extrinsic and monogenic causes explain only a fraction of all cases, common genetic variants are suspected to contribute to the pathogenesis of DCM, its age of onset, and clinical progression. By a large-scale case-control genome-wide association study we aimed here to identify novel genetic risk loci for DCM.
909 European ancestry cases, 2,120 European ancestry controls
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