Active: FEV1 Clear all

GWAS 2025-02-03

Fine-scale population structure and widespread conservation of genetic effect sizes between human groups across traits.

Hu S, Ferreira LAF et al.

Nat Genet

Understanding genetic differences between populations is essential for avoiding confounding in genom...

Forced expiratory volume in 1 second FEV1 (UKB data field 3063)

313684

Participants

N/A

Studies

Details PubMed

GWAS 2024-03-12

Exploiting meta-analysis of genome-wide interaction with serum 25-hydroxyvitamin D to identify novel genetic loci associated with pulmonary function.

Seo J, Gaddis NC et al.

Am J Clin Nutr

Higher 25-hydroxyvitamin D (25(OH)D) concentrations in serum has a positive association with pulmona...

FEV1 x serum 25-hydroxyvitamin D interaction in never smokers (2df test)

115312

Participants

N/A

Studies

Details PubMed

GWAS 2024-01-02

Pulmonary function and atherosclerosis in the general population: causal associations and clinical implications.

Engström G, Lampa E et al.

Eur J Epidemiol

Reduced lung function is associated with cardiovascular mortality, but the relationships with athero...

Forced expiratory volume in 1 second (FEV1)

255647

Participants

N/A

Studies

Details PubMed

GWAS 2023-12-22

Genome Wide Association Study of Preserved Ratio Impaired Spirometry (PRISm).

Higbee DH, Lirio A et al.

Eur Respir J

Preserved ratio impaired spirometry (PRISm) is defined as a forced expiratory volume in 1 s (FEV1) &...

Preserved ratio impaired spirometry

Replicated

342676

Participants

N/A

Studies

Details PubMed

GWAS 2023-12-15

Genetic and observational associations of lung function with gastrointestinal tract diseases: pleiotropic and mendelian randomization analysis.

Jiang M, Hao X et al.

Respir Res

The two-way communications along the gut-lung axis influence the immune function in both gut and lun...

FEV1 or peptic ulcer disease (pleiotropy)

1156925

Participants

N/A

Studies

Details PubMed

GWAS 2023-01-14

A genome-wide association study identifies distinct variants associated with pulmonary function among European and African ancestries from the UK Biobank.

Sinkala M, Elsheikh SSM et al.

Commun Biol

Pulmonary function is an indicator of well-being, and pulmonary pathologies are the third major caus...

FEV1

5978

Participants

N/A

Studies

Details PubMed

GWAS 2023-01-13

Multi-omic association study identifies DNA methylation-mediated genotype and smoking exposure effects on lung function in children living in urban settings.

Dapas M, Thompson EE et al.

PLoS Genet

Impaired lung function in early life is associated with the subsequent development of chronic respir...

Childhood lung function (FEV1/FVC z score) in low-income urban environment

886

Participants

N/A

Studies

Details PubMed

GWAS 2022-02-18

Genetic pleiotropy between pulmonary function and age-related traits: The Long Life Family Study.

Feitosa MF, Wojczynski MK et al.

J Gerontol A Biol Sci Med Sci

Pulmonary function (PF) progressively declines with aging. Forced expiratory volume in the first sec...

Forced vital capacity and interleukin-6 levels and high-sensitivity C-reactive protein levels (pleiotropy)

6229

Participants

N/A

Studies

Details PubMed

GWAS 2021-11-15

Genetic loci for lung function in Japanese adults with adjustment for exhaled nitric oxide levels as airway inflammation indicator.

Yamada M, Motoike IN et al.

Commun Biol

Lung function reflects the ability of the respiratory system and is utilized for the assessment of r...

Lung function (forced expiratory volume in 1 second)

Replicated

19722

Participants

N/A

Studies

Details PubMed

GWAS 2021-07-28

Identification of <i>ROBO2</i> as a Potential Locus Associated with Inhaled Corticosteroid Response in Childhood Asthma.

Hernandez-Pacheco N, Gorenjak M et al.

J Pers Med

Inhaled corticosteroids (ICS) are the most common asthma controller medication. An important contrib...

Response to inhaled corticosteroid treatment in asthma (change in FEV1)

Replicated

339

Participants

N/A

Studies

Details PubMed

GWAS 2021-03-25

A large-scale genome-wide association analysis of lung function in the Chinese population identifies novel loci and highlights shared genetic etiology with obesity.

Zhu Z, Li J et al.

Eur Respir J

Lung function is a heritable complex phenotype with obesity being one of its important risk factors....

Lung function (FEV1)

Replicated

100285

Participants

N/A

Studies

Details PubMed

GWAS 2020-09-29

Integrative genomic analysis in African American children with asthma finds three novel loci associated with lung function.

Goddard PC, Keys KL et al.

Genet Epidemiol

Bronchodilator (BD) drugs are commonly prescribed for treatment and management of obstructive lung f...

Lung function (FVC) in asthma

104

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Fine-scale population structure and widespread conservation of genetic effect sizes between human groups across traits.

Hu S, Ferreira LAF et al.

Nat Genet

Forced expiratory volume in 1 second FEV1 (UKB data field 3063)

2025-02-03

Exploiting meta-analysis of genome-wide interaction with serum 25-hydroxyvitamin D to identify novel genetic loci associated with pulmonary function.

Seo J, Gaddis NC et al.

Am J Clin Nutr

FEV1 x serum 25-hydroxyvitamin D interaction in never smokers (2df test)

2024-03-12

Pulmonary function and atherosclerosis in the general population: causal associations and clinical implications.

Engström G, Lampa E et al.

Eur J Epidemiol

Forced expiratory volume in 1 second (FEV1)

2024-01-02

Genome Wide Association Study of Preserved Ratio Impaired Spirometry (PRISm).

Higbee DH, Lirio A et al.

Eur Respir J

Preserved ratio impaired spirometry

2023-12-22

Genetic and observational associations of lung function with gastrointestinal tract diseases: pleiotropic and mendelian randomization analysis.

Jiang M, Hao X et al.

Respir Res

FEV1 or peptic ulcer disease (pleiotropy)

2023-12-15

A genome-wide association study identifies distinct variants associated with pulmonary function among European and African ancestries from the UK Biobank.

Sinkala M, Elsheikh SSM et al.

Commun Biol

FEV1

2023-01-14

Multi-omic association study identifies DNA methylation-mediated genotype and smoking exposure effects on lung function in children living in urban settings.

Dapas M, Thompson EE et al.

PLoS Genet

Childhood lung function (FEV1/FVC z score) in low-income urban environment

2023-01-13

Genetic pleiotropy between pulmonary function and age-related traits: The Long Life Family Study.

Feitosa MF, Wojczynski MK et al.

J Gerontol A Biol Sci Med Sci

Forced vital capacity and interleukin-6 levels and high-sensitivity C-reactive protein levels (pleiotropy)

2022-02-18

Genetic loci for lung function in Japanese adults with adjustment for exhaled nitric oxide levels as airway inflammation indicator.

Yamada M, Motoike IN et al.

Commun Biol

Lung function (forced expiratory volume in 1 second)

2021-11-15

Identification of <i>ROBO2</i> as a Potential Locus Associated with Inhaled Corticosteroid Response in Childhood Asthma.

Hernandez-Pacheco N, Gorenjak M et al.

J Pers Med

Response to inhaled corticosteroid treatment in asthma (change in FEV1)

2021-07-28

A large-scale genome-wide association analysis of lung function in the Chinese population identifies novel loci and highlights shared genetic etiology with obesity.

Zhu Z, Li J et al.

Eur Respir J

Lung function (FEV1)

2021-03-25

Integrative genomic analysis in African American children with asthma finds three novel loci associated with lung function.

Goddard PC, Keys KL et al.

Genet Epidemiol

Lung function (FVC) in asthma

2020-09-29