Active: Graves' disease Clear all

GWAS 2024-03-17

Genetic and Environmental Factors in Autoimmune Thyroid Disease: Exploring Associations with Selenium Levels and Novel Loci in a Latvian Cohort.

Upmale-Engela S, Vaivode I et al.

Curr Issues Mol Biol

The interplay of genetic, immune and environmental factors strongly contributes to the development o...

Hashimoto thyroiditis

2544

Participants

N/A

Studies

Details PubMed

GWAS 2018-10-26

Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation.

Teumer A, Chaker L et al.

Nat Commun

Thyroid dysfunction is an important public health problem, which affects 10% of the general populati...

Free thyroxine concentration

Replicated

71652

Participants

N/A

Studies

Details PubMed

GWAS 2017-12-07

Genome-Wide Association Study of Male Sexual Orientation.

Sanders AR, Beecham GW et al.

Sci Rep

Family and twin studies suggest that genes play a role in male sexual orientation. We conducted a ge...

Male sexual orientation

2308

Participants

N/A

Studies

Details PubMed

GWAS 2016-06-01

Association of Polymorphisms in MACRO Domain Containing 2 With Thyroid-Associated Orbitopathy.

Khong JJ, Burdon KP et al.

Invest Ophthalmol Vis Sci

Purpose: Thyroid-associated orbitopathy (TO) is an autoimmune-mediated orbital inflammation that can...

Thyroid-associated orbitopathy in graves' disease

Replicated

951

Participants

N/A

Studies

Details PubMed

GWAS 2015-07-07

Genetic determinants of antithyroid drug-induced agranulocytosis by human leukocyte antigen genotyping and genome-wide association study.

Chen PL, Shih SR et al.

Nat Commun

Graves' disease is the leading cause of hyperthyroidism affecting 1.0-1.6% of the population. Antith...

Thionamide-induced agranulocytosis in Graves' disease

Replicated

1250

Participants

N/A

Studies

Details PubMed

GWAS 2014-11-27

Identification of a Hashimoto thyroiditis susceptibility locus via a genome-wide comparison with Graves' disease.

Oryoji D, Ueda S et al.

J Clin Endocrinol Metab

Hashimoto thyroiditis (HT) and Graves' disease (GD) share some immunological features. Determining t...

Hashimoto thyroiditis versus Graves' disease

Replicated

990

Participants

N/A

Studies

Details PubMed

GWAS 2014-02-27

Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease.

Medici M, Porcu E et al.

PLoS Genet

Autoimmune thyroid diseases (AITD) are common, affecting 2-5% of the general population. Individuals...

Thyroid peroxidase antibody positivity

Replicated

27287

Participants

N/A

Studies

Details PubMed

GWAS 2013-04-29

Robust evidence for five new Graves' disease risk loci from a staged genome-wide association analysis.

Zhao SX, Xue LQ et al.

Hum Mol Genet

Graves' disease (GD), characterized by autoantibodies targeting antigens specifically expressed in t...

Graves' disease

Replicated

19152

Participants

N/A

Studies

Details PubMed

GWAS 2013-01-31

Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.

Lauc G, Huffman JE et al.

PLoS Genet

Glycosylation of immunoglobulin G (IgG) influences IgG effector function by modulating binding to Fc...

IgG glycosylation

2247

Participants

N/A

Studies

Details PubMed

GWAS 2012-12-01

Seven newly identified loci for autoimmune thyroid disease.

Cooper JD, Simmonds MJ et al.

Hum Mol Genet

Autoimmune thyroid disease (AITD), including Graves' disease (GD) and Hashimoto's thyroiditis (HT), ...

Graves' disease

11649

Participants

N/A

Studies

Details PubMed

GWAS 2012-08-05

Genome-wide association study identifies a susceptibility locus for thyrotoxic periodic paralysis at 17q24.3.

Cheung CL, Lau KS et al.

Nat Genet

Thyrotoxic periodic paralysis (TPP) is a potentially life-threatening complication of thyrotoxicosis...

Thyrotoxic hypokalemic periodic paralysis

Replicated

1693

Participants

N/A

Studies

Details PubMed

GWAS 2012-03-25

Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population.

Okada Y, Terao C et al.

Nat Genet

Rheumatoid arthritis is a common autoimmune disease characterized by chronic inflammation. We report...

Rheumatoid arthritis

Replicated

47926

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genetic and Environmental Factors in Autoimmune Thyroid Disease: Exploring Associations with Selenium Levels and Novel Loci in a Latvian Cohort.

Upmale-Engela S, Vaivode I et al.

Curr Issues Mol Biol

Hashimoto thyroiditis

2024-03-17

Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation.

Teumer A, Chaker L et al.

Nat Commun

Free thyroxine concentration

2018-10-26

Genome-Wide Association Study of Male Sexual Orientation.

Sanders AR, Beecham GW et al.

Sci Rep

Male sexual orientation

2017-12-07

Association of Polymorphisms in MACRO Domain Containing 2 With Thyroid-Associated Orbitopathy.

Khong JJ, Burdon KP et al.

Invest Ophthalmol Vis Sci

Thyroid-associated orbitopathy in graves' disease

2016-06-01

Genetic determinants of antithyroid drug-induced agranulocytosis by human leukocyte antigen genotyping and genome-wide association study.

Chen PL, Shih SR et al.

Nat Commun

Thionamide-induced agranulocytosis in Graves' disease

2015-07-07

Identification of a Hashimoto thyroiditis susceptibility locus via a genome-wide comparison with Graves' disease.

Oryoji D, Ueda S et al.

J Clin Endocrinol Metab

Hashimoto thyroiditis versus Graves' disease

2014-11-27

Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease.

Medici M, Porcu E et al.

PLoS Genet

Thyroid peroxidase antibody positivity

2014-02-27

Robust evidence for five new Graves' disease risk loci from a staged genome-wide association analysis.

Zhao SX, Xue LQ et al.

Hum Mol Genet

Graves' disease

2013-04-29

Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.

Lauc G, Huffman JE et al.

PLoS Genet

IgG glycosylation

2013-01-31

Seven newly identified loci for autoimmune thyroid disease.

Cooper JD, Simmonds MJ et al.

Hum Mol Genet

Graves' disease

2012-12-01

Genome-wide association study identifies a susceptibility locus for thyrotoxic periodic paralysis at 17q24.3.

Cheung CL, Lau KS et al.

Nat Genet

Thyrotoxic hypokalemic periodic paralysis

2012-08-05

Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population.

Okada Y, Terao C et al.

Nat Genet

Rheumatoid arthritis

2012-03-25