Active: Ischemic heart disease Clear all

GWAS 2024-03-20

Genetic evidence for T-wave area from 12-lead electrocardiograms to monitor cardiovascular diseases in patients taking diabetes medications.

Qi M, Zhang H et al.

Hum Genet

Aims Many studies indicated use of diabetes medications can influence the electrocardiogram (ECG), w...

R peak area in lead V2

42340

Participants

N/A

Studies

Details PubMed

GWAS 2024-01-10

Comprehensive genetic study of the insulin resistance marker TG:HDL-C in the UK Biobank.

Oliveri A, Rebernick RJ et al.

Nat Genet

Insulin resistance (IR) is a well-established risk factor for metabolic disease. The ratio of trigly...

Triglyceride to HDL cholesterol ratio

402398

Participants

N/A

Studies

Details PubMed

GWAS 2024-01-05

Genome-wide association and Mendelian randomization analysis provide insights into the shared genetic architecture between high-dimensional electrocardiographic features and ischemic heart disease.

Wang X, Qi M et al.

Hum Genet

Observational studies have revealed that ischemic heart disease (IHD) has a unique manifestation on ...

12-lead ECG morphology phenotype

41960

Participants

N/A

Studies

Details PubMed

GWAS 2023-03-28

Unprocessed Red Meat and Processed Meat Consumption, Plasma Metabolome, and Risk of Ischemic Heart Disease: A Prospective Cohort Study of UK Biobank.

Dong X, Zhuang Z et al.

J Am Heart Assoc

Background The evidence is equivocal on the association between meat consumption and ischemic heart ...

Red meat related metabolomic signature

92246

Participants

N/A

Studies

Details PubMed

GWAS 2022-12-29

Genomics and phenomics of body mass index reveals a complex disease network.

Huang J, Huffman JE et al.

Nat Commun

Elevated body mass index (BMI) is heritable and associated with many health conditions that impact m...

Body mass index

1122049

Participants

N/A

Studies

Details PubMed

GWAS 2022-10-06

Calcification of the abdominal aorta is an under-appreciated cardiovascular disease risk factor in the general population.

Sethi A, Taylor DL et al.

Front Cardiovasc Med

Calcification of large arteries is a high-risk factor in the development of cardiovascular diseases,...

Abdominal aortic calcification levels

Replicated

72989

Participants

N/A

Studies

Details PubMed

GWAS 2021-11-02

Genome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry.

Sanchez-Roige S, Fontanillas P et al.

Mol Psychiatry

The growing prevalence of opioid use disorder (OUD) constitutes an urgent health crisis. Ample evide...

Problematic opioid prescription use

132113

Participants

N/A

Studies

Details PubMed

GWAS 2019-12-05

Carotid Intima-Media Thickness: Novel Loci, Sex-Specific Effects, and Genetic Correlations With Obesity and Glucometabolic Traits in UKB.

Strawbridge RJ, Ward J et al.

Arterioscler Thromb Vasc Biol

Objective: Atherosclerosis is the underlying cause of most cardiovascular disease, but mechanisms un...

Carotid intima media thickness (mean)

22179

Participants

N/A

Studies

Details PubMed

GWAS 2019-07-12

Bilirubin and risk of ischemic heart disease in Korea: A two-sample Mendelian randomization study.

Jeon C, Lee JY et al.

Epidemiol Health

Objectives: Bilirubin is an endogenous antioxidant that protects cells against oxidative stress. Inc...

Ischemic heart disease

13855

Participants

N/A

Studies

Details PubMed

GWAS 2017-07-17

Association analyses based on false discovery rate implicate new loci for coronary artery disease.

Nelson CP, Goel A et al.

Nat Genet

Genome-wide association studies (GWAS) in coronary artery disease (CAD) had identified 66 loci at 'g...

Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease)

Replicated

340599

Participants

N/A

Studies

Details PubMed

GWAS 2017-04-18

Leveraging cell type specific regulatory regions to detect SNPs associated with tissue factor pathway inhibitor plasma levels.

Dennis J, Medina-Rivera A et al.

Genet Epidemiol

Tissue factor pathway inhibitor (TFPI) regulates the formation of intravascular blood clots, which m...

Tissue factor pathway inhibitor levels

Replicated

1284

Participants

N/A

Studies

Details PubMed

GWAS 2007-11-17

A novel genetic marker for coronary spasm in women from a genome-wide single nucleotide polymorphism analysis.

Suzuki S, Yoshimura M et al.

Pharmacogenet Genomics

Objective: Coronary spasm plays an important role in the pathogenesis of variant angina and also isc...

Coronary spasm

Replicated

411

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genetic evidence for T-wave area from 12-lead electrocardiograms to monitor cardiovascular diseases in patients taking diabetes medications.

Qi M, Zhang H et al.

Hum Genet

R peak area in lead V2

2024-03-20

Comprehensive genetic study of the insulin resistance marker TG:HDL-C in the UK Biobank.

Oliveri A, Rebernick RJ et al.

Nat Genet

Triglyceride to HDL cholesterol ratio

2024-01-10

Genome-wide association and Mendelian randomization analysis provide insights into the shared genetic architecture between high-dimensional electrocardiographic features and ischemic heart disease.

Wang X, Qi M et al.

Hum Genet

12-lead ECG morphology phenotype

2024-01-05

Unprocessed Red Meat and Processed Meat Consumption, Plasma Metabolome, and Risk of Ischemic Heart Disease: A Prospective Cohort Study of UK Biobank.

Dong X, Zhuang Z et al.

J Am Heart Assoc

Red meat related metabolomic signature

2023-03-28

Genomics and phenomics of body mass index reveals a complex disease network.

Huang J, Huffman JE et al.

Nat Commun

Body mass index

2022-12-29

Calcification of the abdominal aorta is an under-appreciated cardiovascular disease risk factor in the general population.

Sethi A, Taylor DL et al.

Front Cardiovasc Med

Abdominal aortic calcification levels

2022-10-06

Genome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry.

Sanchez-Roige S, Fontanillas P et al.

Mol Psychiatry

Problematic opioid prescription use

2021-11-02

Carotid Intima-Media Thickness: Novel Loci, Sex-Specific Effects, and Genetic Correlations With Obesity and Glucometabolic Traits in UKB.

Strawbridge RJ, Ward J et al.

Arterioscler Thromb Vasc Biol

Carotid intima media thickness (mean)

2019-12-05

Bilirubin and risk of ischemic heart disease in Korea: A two-sample Mendelian randomization study.

Jeon C, Lee JY et al.

Epidemiol Health

Ischemic heart disease

2019-07-12

Association analyses based on false discovery rate implicate new loci for coronary artery disease.

Nelson CP, Goel A et al.

Nat Genet

Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease)

2017-07-17

Leveraging cell type specific regulatory regions to detect SNPs associated with tissue factor pathway inhibitor plasma levels.

Dennis J, Medina-Rivera A et al.

Genet Epidemiol

Tissue factor pathway inhibitor levels

2017-04-18

A novel genetic marker for coronary spasm in women from a genome-wide single nucleotide polymorphism analysis.

Suzuki S, Yoshimura M et al.

Pharmacogenet Genomics

Coronary spasm

2007-11-17