Active: Nicotine dependence Clear all

GWAS 2021-10-14

White Matter Integrity and Nicotine Dependence: Evaluating Vertical and Horizontal Pleiotropy.

Ye Z, Mo C et al.

Front Neurosci

Tobacco smoking is an addictive behavior that supports nicotine dependence and is an independent ris...

Smoking behavior

293759

Participants

N/A

Studies

Details PubMed

GWAS 2020-11-03

Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits.

Quach BC, Bray MJ et al.

Nat Commun

Cigarette smoking is the leading cause of preventable morbidity and mortality. Genetic variation con...

Nicotine dependence

Replicated

91791

Participants

N/A

Studies

Details PubMed

GWAS 2020-04-13

Gene-based association analysis reveals involvement of LAMA5 and cell adhesion pathways in nicotine dependence in African- and European-American samples.

Fan R, Cui W et al.

Addict Biol

Nicotine dependence (ND) is a chronic brain disorder that causes heavy social and economic burdens. ...

Nicotine dependence

Replicated

4943

Participants

N/A

Studies

Details PubMed

GWAS 2019-07-11

Genome-Wide Meta-Analyses of FTND and TTFC Phenotypes.

Chen J, Loukola A et al.

Nicotine Tob Res

Introduction: FTND (Fagerstrӧm test for nicotine dependence) and TTFC (time to smoke first cigarette...

Fagerstrӧm test for nicotine dependence

Replicated

26441

Participants

N/A

Studies

Details PubMed

GWAS 2018-11-28

GWAS and network analysis of co-occurring nicotine and alcohol dependence identifies significantly associated alleles and network.

Xiang B, Yang BZ et al.

Am J Med Genet B Neuropsychiatr Genet

Alcohol dependence (AD) and nicotine dependence (ND) co-occur frequently (AD+ND). We integrated SNP-...

Alcohol and nicotine co-dependence

Replicated

3979

Participants

N/A

Studies

Details PubMed

GWAS 2018-10-04

Genome-wide association study identifies glutamate ionotropic receptor GRIA4 as a risk gene for comorbid nicotine dependence and major depression.

Zhou H, Cheng Z et al.

Transl Psychiatry

Smoking and major depression frequently co-occur, at least in part due to shared genetic risk. Howev...

Nicotine dependence and major depression (severity of comorbidity)

3724

Participants

N/A

Studies

Details PubMed

GWAS 2018-03-13

Genome-wide association study in Finnish twins highlights the connection between nicotine addiction and neurotrophin signaling pathway.

Hällfors J, Palviainen T et al.

Addict Biol

The heritability of nicotine dependence based on family studies is substantial. Nevertheless, knowle...

Smoking behaviour (cigarettes smoked per day)

Replicated

9059

Participants

N/A

Studies

Details PubMed

GWAS 2017-10-03

Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence.

Hancock DB, Guo Y et al.

Mol Psychiatry

Cigarette smoking is a leading cause of preventable mortality worldwide. Nicotine dependence, which ...

Nicotine dependence

38602

Participants

N/A

Studies

Details PubMed

GWAS 2017-05-17

Genome-wide association study of heavy smoking and daily/nondaily smoking in the Hispanic Community Health Study / Study of Latinos (HCHS/SOL).

Saccone NL, Emery LS et al.

Nicotine Tob Res

Introduction: Genetic variants associated with nicotine dependence have previously been identified, ...

Smoking status (daily vs non-daily)

Replicated

5804

Participants

N/A

Studies

Details PubMed

GWAS 2017-04-25

Genome-wide meta-analysis identifies a novel susceptibility signal at CACNA2D3 for nicotine dependence.

Yin X, Bizon C et al.

Am J Med Genet B Neuropsychiatr Genet

Nicotine dependence (ND) has a reported heritability of 40-70%. Low-coverage whole-genome sequencing...

Nicotine dependence

18082

Participants

N/A

Studies

Details PubMed

GWAS 2015-10-06

Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence.

Hancock DB, Reginsson GW et al.

Transl Psychiatry

We conducted a 1000 Genomes-imputed genome-wide association study (GWAS) meta-analysis for nicotine ...

Nicotine dependence

Replicated

24543

Participants

N/A

Studies

Details PubMed

GWAS 2015-08-20

Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies.

Nishizawa D, Kasai S et al.

Mol Brain

Many genetic and environmental factors are involved in the etiology of nicotine dependence. Although...

Nicotine dependence

Replicated

522

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

White Matter Integrity and Nicotine Dependence: Evaluating Vertical and Horizontal Pleiotropy.

Ye Z, Mo C et al.

Front Neurosci

Smoking behavior

2021-10-14

Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits.

Quach BC, Bray MJ et al.

Nat Commun

Nicotine dependence

2020-11-03

Gene-based association analysis reveals involvement of LAMA5 and cell adhesion pathways in nicotine dependence in African- and European-American samples.

Fan R, Cui W et al.

Addict Biol

Nicotine dependence

2020-04-13

Genome-Wide Meta-Analyses of FTND and TTFC Phenotypes.

Chen J, Loukola A et al.

Nicotine Tob Res

Fagerstrӧm test for nicotine dependence

2019-07-11

GWAS and network analysis of co-occurring nicotine and alcohol dependence identifies significantly associated alleles and network.

Xiang B, Yang BZ et al.

Am J Med Genet B Neuropsychiatr Genet

Alcohol and nicotine co-dependence

2018-11-28

Genome-wide association study identifies glutamate ionotropic receptor GRIA4 as a risk gene for comorbid nicotine dependence and major depression.

Zhou H, Cheng Z et al.

Transl Psychiatry

Nicotine dependence and major depression (severity of comorbidity)

2018-10-04

Genome-wide association study in Finnish twins highlights the connection between nicotine addiction and neurotrophin signaling pathway.

Hällfors J, Palviainen T et al.

Addict Biol

Smoking behaviour (cigarettes smoked per day)

2018-03-13

Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence.

Hancock DB, Guo Y et al.

Mol Psychiatry

Nicotine dependence

2017-10-03

Genome-wide association study of heavy smoking and daily/nondaily smoking in the Hispanic Community Health Study / Study of Latinos (HCHS/SOL).

Saccone NL, Emery LS et al.

Nicotine Tob Res

Smoking status (daily vs non-daily)

2017-05-17

Genome-wide meta-analysis identifies a novel susceptibility signal at CACNA2D3 for nicotine dependence.

Yin X, Bizon C et al.

Am J Med Genet B Neuropsychiatr Genet

Nicotine dependence

2017-04-25

Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence.

Hancock DB, Reginsson GW et al.

Transl Psychiatry

Nicotine dependence

2015-10-06

Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies.

Nishizawa D, Kasai S et al.

Mol Brain

Nicotine dependence

2015-08-20