Active: Osteoporosis Clear all

GWAS 2025-11-05

Genome-wide Association Studies of over 30,000 Samples with Bone Mineral Density at Multiple Skeletal Sites and Its Clinical Relevance.

Qian Y, Xia J et al.

Genomics Proteomics Bioinformatics

The ultimate goal of a genome-wide association study (GWAS) is to translate its discoveries into cli...

DXA-Bone mineral density (lumbar spine)

30449

Participants

N/A

Studies

Details PubMed

GWAS 2025-08-12

Genetic architecture of bone marrow fat fraction implies its involvement in osteoporosis risk.

Wu Z, Yang Y et al.

Nat Commun

Bone marrow adipose tissue, as a distinct adipose subtype, has been implicated in the pathophysiolog...

Bone marrow fat fraction of thoracic vertebra 8

39007

Participants

N/A

Studies

Details PubMed

GWAS 2024-03-05

Identification of an novel genetic variant associated with osteoporosis: insights from the Taiwan Biobank Study.

Liaw YC, Matsuda K et al.

JBMR Plus

Purpose: The purpose of this study was to identify new independent significant SNPs associated with ...

Osteoporosis

Replicated

48002

Participants

N/A

Studies

Details PubMed

GWAS 2023-09-03

Interactions between Polygenetic Variants and Lifestyle Factors in Hypothyroidism: A Hospital-Based Cohort Study.

Kim DS, Park S

Nutrients

Hypothyroidism is a prevalent endocrine disorder and is associated with a variety of metabolic distu...

Hypothyroidism

56124

Participants

N/A

Studies

Details PubMed

GWAS 2023-08-24

Genetic correlation, shared loci and causal association between sex hormone-binding globulin and bone mineral density: insights from a large-scale genome-wide cross-trait analysis.

Qu Y, Xiao C et al.

J Bone Miner Res

Although the impact of sex hormones on bone metabolism is well-documented, effect of their primary m...

Sex hormone-binding globulin levels and heel estimated bone mineral density

832949

Participants

N/A

Studies

Details PubMed

GWAS 2023-07-27

A longitudinal genome-wide association study of bone mineral density mean and variability in the UK Biobank.

He D, Liu H et al.

Osteoporos Int

Bone mineral density (BMD) is an essential predictor of osteoporosis and fracture. We conducted a ge...

Bone mineral density mean

141261

Participants

N/A

Studies

Details PubMed

GWAS 2023-07-04

Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis.

Medina-Gomez C, Mullin BH et al.

Commun Biol

Skull bone mineral density (SK-BMD) provides a suitable trait for the discovery of key genes in bone...

Skull bone mineral density

43832

Participants

N/A

Studies

Details PubMed

GWAS 2023-04-25

Lowering of circulating sclerostin may increase risk of atherosclerosis and its risk factors: evidence from a genome-wide association meta-analysis followed by Mendelian randomization.

Zheng J, Wheeler E et al.

Arthritis Rheumatol

Objective: In this study, we aimed to establish the causal effects of lowering sclerostin, target of...

Serum sclerostin levels

33961

Participants

N/A

Studies

Details PubMed

GWAS 2023-03-20

Genome-wide association study identifies genetic variants which predict the response of bone mineral density to teriparatide therapy.

Alonso N, Albagha OME et al.

Ann Rheum Dis

Objectives: Teriparatide (TPTD) is an effective treatment for osteoporosis but the individual respon...

Response of lumbar spine BMD to teriparatide in osteoporosis

437

Participants

N/A

Studies

Details PubMed

GWAS 2023-01-27

Candidate loci shared among periodontal disease, diabetes and bone density.

Yu YH, Steffensen B et al.

Front Endocrinol (Lausanne)

Introduction: While periodontal disease (PD) has been associated with type 2 diabetes (T2D) and oste...

Periodontitis / loose teeth (MTAG)

506594

Participants

N/A

Studies

Details PubMed

GWAS 2022-01-29

Effect of dietary calcium on the gender-specific association between polymorphisms in the PTPRD locus and osteoporosis.

Bae JH, Park D

Clin Nutr

Background & aims: Osteoporosis is the most common bone disease and is characterized by low bone...

Osteoporosis

8842

Participants

N/A

Studies

Details PubMed

GWAS 2021-11-18

Regulatory SNP of <i>RREB1</i> is Associated With Bone Mineral Density in Chinese Postmenopausal Osteoporosis Patients.

Feng S, Wang H et al.

Front Genet

Postmenopausal osteoporosis (PMO) is the most common bone disorder in elderly Chinese women. Althoug...

Bone mineral density T score in postmenopausal osteoporosis

Replicated

341

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genome-wide Association Studies of over 30,000 Samples with Bone Mineral Density at Multiple Skeletal Sites and Its Clinical Relevance.

Qian Y, Xia J et al.

Genomics Proteomics Bioinformatics

DXA-Bone mineral density (lumbar spine)

2025-11-05

Genetic architecture of bone marrow fat fraction implies its involvement in osteoporosis risk.

Wu Z, Yang Y et al.

Nat Commun

Bone marrow fat fraction of thoracic vertebra 8

2025-08-12

Identification of an novel genetic variant associated with osteoporosis: insights from the Taiwan Biobank Study.

Liaw YC, Matsuda K et al.

JBMR Plus

Osteoporosis

2024-03-05

Interactions between Polygenetic Variants and Lifestyle Factors in Hypothyroidism: A Hospital-Based Cohort Study.

Kim DS, Park S

Nutrients

Hypothyroidism

2023-09-03

Genetic correlation, shared loci and causal association between sex hormone-binding globulin and bone mineral density: insights from a large-scale genome-wide cross-trait analysis.

Qu Y, Xiao C et al.

J Bone Miner Res

Sex hormone-binding globulin levels and heel estimated bone mineral density

2023-08-24

A longitudinal genome-wide association study of bone mineral density mean and variability in the UK Biobank.

He D, Liu H et al.

Osteoporos Int

Bone mineral density mean

2023-07-27

Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis.

Medina-Gomez C, Mullin BH et al.

Commun Biol

Skull bone mineral density

2023-07-04

Lowering of circulating sclerostin may increase risk of atherosclerosis and its risk factors: evidence from a genome-wide association meta-analysis followed by Mendelian randomization.

Zheng J, Wheeler E et al.

Arthritis Rheumatol

Serum sclerostin levels

2023-04-25

Genome-wide association study identifies genetic variants which predict the response of bone mineral density to teriparatide therapy.

Alonso N, Albagha OME et al.

Ann Rheum Dis

Response of lumbar spine BMD to teriparatide in osteoporosis

2023-03-20

Candidate loci shared among periodontal disease, diabetes and bone density.

Yu YH, Steffensen B et al.

Front Endocrinol (Lausanne)

Periodontitis / loose teeth (MTAG)

2023-01-27

Effect of dietary calcium on the gender-specific association between polymorphisms in the PTPRD locus and osteoporosis.

Bae JH, Park D

Clin Nutr

Osteoporosis

2022-01-29

Regulatory SNP of <i>RREB1</i> is Associated With Bone Mineral Density in Chinese Postmenopausal Osteoporosis Patients.

Feng S, Wang H et al.

Front Genet

Bone mineral density T score in postmenopausal osteoporosis

2021-11-18