Active: QT interval Clear all

GWAS 2022-10-22

A large genome-wide association study of QT interval length utilizing electronic health records.

Hoffmann TJ, Lu M et al.

Genetics

QT interval length is an important risk factor for adverse cardiovascular outcomes; however, the gen...

QT interval

76995

Participants

N/A

Studies

Details PubMed

GWAS 2022-09-01

Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways.

Young WJ, Lahrouchi N et al.

Nat Commun

The QT interval is an electrocardiographic measure representing the sum of ventricular depolarizatio...

QT interval

252730

Participants

N/A

Studies

Details PubMed

GWAS 2022-04-07

Monogenic and Polygenic Contributions to QTc Prolongation in the Population.

Nauffal V, Morrill VN et al.

Circulation

Rare sequence variation in genes underlying cardiac repolarization and common polygenic variation in...

QTc interval

Replicated

111606

Participants

N/A

Studies

Details PubMed

GWAS 2021-07-19

Genomic and pleiotropic analyses of resting QT interval identifies novel loci and overlap with atrial electrical disorders.

van Duijvenboden S, Ramírez J et al.

Hum Mol Genet

The resting QT interval, an electrocardiographic (ECG) measure of ventricular myocardial repolarizat...

QT interval

Replicated

101104

Participants

N/A

Studies

Details PubMed

GWAS 2020-06-11

Genetic Basis and Prognostic Value of Exercise QT Dynamics.

van Duijvenboden S, Ramírez J et al.

Circ Genom Precis Med

Abnormal QT interval responses to heart rate (QT dynamics) is an independent risk predictor for card...

QT dynamics during exercise

52861

Participants

N/A

Studies

Details PubMed

GWAS 2019-01-24

Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits.

van Setten J, Verweij N et al.

Eur J Hum Genet

Genome-wide association studies (GWAS) of quantitative electrocardiographic (ECG) traits in large co...

PR interval

Replicated

66170

Participants

N/A

Studies

Details PubMed

GWAS 2018-01-01

ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals.

Bihlmeyer NA, Brody JA et al.

Circ Genom Precis Med

QT interval, measured through a standard ECG, captures the time it takes for the cardiac ventricles ...

QT interval

95626

Participants

N/A

Studies

Details PubMed

GWAS 2017-12-06

GWAS of the electrocardiographic QT interval in Hispanics/Latinos generalizes previously identified loci and identifies population-specific signals.

Méndez-Giráldez R, Gogarten SM et al.

Sci Rep

QT interval prolongation is a heritable risk factor for ventricular arrhythmias and can predispose t...

QT interval

15997

Participants

N/A

Studies

Details PubMed

GWAS 2017-06-08

Genome-wide Association Study of Susceptibility to Particulate Matter-Associated QT Prolongation.

Gondalia R, Avery CL et al.

Environ Health Perspect

Ambient particulate matter (PM) air pollution exposure has been associated with increases in QT inte...

QT interval (ambient particulate matter interaction)

22158

Participants

N/A

Studies

Details PubMed

GWAS 2016-12-30

A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.

Noordam R, Sitlani CM et al.

J Med Genet

Increased heart rate and a prolonged QT interval are important risk factors for cardiovascular morbi...

QT interval (tricyclic/tetracyclic antidepressant use interaction)

121935

Participants

N/A

Studies

Details PubMed

GWAS 2016-12-13

Large-scale pharmacogenomic study of sulfonylureas and the QT, JT and QRS intervals: CHARGE Pharmacogenomics Working Group.

Floyd JS, Sitlani CM et al.

Pharmacogenomics J

Sulfonylureas, a commonly used class of medication used to treat type 2 diabetes, have been associat...

QT interval (sulfonylurea treatment interaction)

71857

Participants

N/A

Studies

Details PubMed

GWAS 2014-07-23

Genome-wide association study of electrocardiographic parameters identifies a new association for PR interval and confirms previously reported associations.

Sano M, Kamitsuji S et al.

Hum Mol Genet

Previous reports have described several associations of PR, QRS, QT and heart rate with genomic vari...

Electrocardiographic traits

Replicated

9799

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

A large genome-wide association study of QT interval length utilizing electronic health records.

Hoffmann TJ, Lu M et al.

Genetics

QT interval

2022-10-22

Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways.

Young WJ, Lahrouchi N et al.

Nat Commun

QT interval

2022-09-01

Monogenic and Polygenic Contributions to QTc Prolongation in the Population.

Nauffal V, Morrill VN et al.

Circulation

QTc interval

2022-04-07

Genomic and pleiotropic analyses of resting QT interval identifies novel loci and overlap with atrial electrical disorders.

van Duijvenboden S, Ramírez J et al.

Hum Mol Genet

QT interval

2021-07-19

Genetic Basis and Prognostic Value of Exercise QT Dynamics.

van Duijvenboden S, Ramírez J et al.

Circ Genom Precis Med

QT dynamics during exercise

2020-06-11

Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits.

van Setten J, Verweij N et al.

Eur J Hum Genet

PR interval

2019-01-24

ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals.

Bihlmeyer NA, Brody JA et al.

Circ Genom Precis Med

QT interval

2018-01-01

GWAS of the electrocardiographic QT interval in Hispanics/Latinos generalizes previously identified loci and identifies population-specific signals.

Méndez-Giráldez R, Gogarten SM et al.

Sci Rep

QT interval

2017-12-06

Genome-wide Association Study of Susceptibility to Particulate Matter-Associated QT Prolongation.

Gondalia R, Avery CL et al.

Environ Health Perspect

QT interval (ambient particulate matter interaction)

2017-06-08

A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.

Noordam R, Sitlani CM et al.

J Med Genet

QT interval (tricyclic/tetracyclic antidepressant use interaction)

2016-12-30

Large-scale pharmacogenomic study of sulfonylureas and the QT, JT and QRS intervals: CHARGE Pharmacogenomics Working Group.

Floyd JS, Sitlani CM et al.

Pharmacogenomics J

QT interval (sulfonylurea treatment interaction)

2016-12-13

Genome-wide association study of electrocardiographic parameters identifies a new association for PR interval and confirms previously reported associations.

Sano M, Kamitsuji S et al.

Hum Mol Genet

Electrocardiographic traits

2014-07-23