Monogenic and Polygenic Contributions to QTc Prolongation in the Population.
Nauffal V, Morrill VN, Jurgens SJ et al.
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Abstract
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Rare sequence variation in genes underlying cardiac repolarization and common polygenic variation influence QT interval duration. However, current clinical genetic testing of individuals with unexplained QT prolongation is restricted to examination of monogenic rare variants. The recent emergence of large-scale biorepositories with sequence data enables examination of the joint contribution of rare and common variations to the QT interval in the population.
79,167 European ancestry individuals, 1,614 African ancestry individuals, 78 Hispanic or Latin American individuals, 1,500 Asian ancestry individuals, 2,271 individuals
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