Active: Systemic sclerosis Clear all

GWAS 2024-01-31

GWAS for systemic sclerosis identifies six novel susceptibility loci including one in the Fcγ receptor region.

Ishikawa Y, Tanaka N et al.

Nat Commun

Here we report the largest Asian genome-wide association study (GWAS) for systemic sclerosis perform...

Systemic sclerosis

140706

Participants

N/A

Studies

Details PubMed

GWAS 2020-10-15

Exome-wide association analysis suggests LRP2BP as a susceptibility gene for endothelial injury in systemic sclerosis in Han Chinese population.

Pu W, Wu W et al.

J Invest Dermatol

Genetic factors play a key role in the pathogenesis of autoimmune diseases, whereas the disease-caus...

Systemic sclerosis

Replicated

7126

Participants

N/A

Studies

Details PubMed

GWAS 2020-02-05

A cross-disease meta-GWAS identifies four new susceptibility loci shared between systemic sclerosis and Crohn's disease.

González-Serna D, Ochoa E et al.

Sci Rep

Genome-wide association studies (GWASs) have identified a number of genetic risk loci associated wit...

Crohn's disease or systemic sclerosis

Replicated

24890

Participants

N/A

Studies

Details PubMed

GWAS 2019-10-31

GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways.

López-Isac E, Acosta-Herrera M et al.

Nat Commun

Systemic sclerosis (SSc) is an autoimmune disease that shows one of the highest mortality rates amon...

Systemic sclerosis

26679

Participants

N/A

Studies

Details PubMed

GWAS 2018-12-20

Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases.

Acosta-Herrera M, Kerick M et al.

Ann Rheum Dis

Objective: Immune-mediated inflammatory diseases (IMIDs) are heterogeneous and complex conditions wi...

Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies)

31382

Participants

N/A

Studies

Details PubMed

GWAS 2018-09-21

Analysis of the genetic component of systemic sclerosis in Iranian and Turkish populations through a genome-wide association study.

González-Serna D, López-Isac E et al.

Rheumatology (Oxford)

Objectives: SSc is an autoimmune disease characterized by alteration of the immune response, vasculo...

Systemic sclerosis

2107

Participants

N/A

Studies

Details PubMed

GWAS 2018-01-02

Gene-level association analysis of systemic sclerosis: A comparison of African-Americans and White populations.

Gorlova OY, Li Y et al.

PLoS One

Gene-level analysis of ImmunoChip or genome-wide association studies (GWAS) data has not been previo...

Systemic sclerosis

5850

Participants

N/A

Studies

Details PubMed

GWAS 2017-03-17

Transethnic meta-analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis.

Terao C, Kawaguchi T et al.

Ann Rheum Dis

Objectives: Systemic sclerosis (SSc) is an autoimmune disease characterised by skin and systemic fib...

Systemic sclerosis

Replicated

19171

Participants

N/A

Studies

Details PubMed

GWAS 2014-01-02

Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis.

Mayes MD, Bossini-Castillo L et al.

Am J Hum Genet

In this study, 1,833 systemic sclerosis (SSc) cases and 3,466 controls were genotyped with the Immun...

Diffuse cutaneous systemic sclerosis

Replicated

11192

Participants

N/A

Studies

Details PubMed

GWAS 2013-06-10

A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.

Martin JE, Assassi S et al.

Hum Mol Genet

Systemic sclerosis (SSc) and systemic lupus erythematosus (SLE) are two archetypal systemic autoimmu...

Systemic lupus erythematosus and Systemic sclerosis

Replicated

21109

Participants

N/A

Studies

Details PubMed

GWAS 2011-10-17

Association of CD247 with systemic lupus erythematosus in Asian populations.

Li R, Yang W et al.

Lupus

Objective: Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease with complex geneti...

Systemic lupus erythematosus

Replicated

11922

Participants

N/A

Studies

Details PubMed

GWAS 2011-07-14

Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.

Gorlova O, Martin JE et al.

PLoS Genet

The aim of this study was to determine, through a genome-wide association study (GWAS), the genetic ...

Systemic sclerosis

Replicated

14853

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

GWAS for systemic sclerosis identifies six novel susceptibility loci including one in the Fcγ receptor region.

Ishikawa Y, Tanaka N et al.

Nat Commun

Systemic sclerosis

2024-01-31

Exome-wide association analysis suggests LRP2BP as a susceptibility gene for endothelial injury in systemic sclerosis in Han Chinese population.

Pu W, Wu W et al.

J Invest Dermatol

Systemic sclerosis

2020-10-15

A cross-disease meta-GWAS identifies four new susceptibility loci shared between systemic sclerosis and Crohn's disease.

González-Serna D, Ochoa E et al.

Sci Rep

Crohn's disease or systemic sclerosis

2020-02-05

GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways.

López-Isac E, Acosta-Herrera M et al.

Nat Commun

Systemic sclerosis

2019-10-31

Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases.

Acosta-Herrera M, Kerick M et al.

Ann Rheum Dis

Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies)

2018-12-20

Analysis of the genetic component of systemic sclerosis in Iranian and Turkish populations through a genome-wide association study.

González-Serna D, López-Isac E et al.

Rheumatology (Oxford)

Systemic sclerosis

2018-09-21

Gene-level association analysis of systemic sclerosis: A comparison of African-Americans and White populations.

Gorlova OY, Li Y et al.

PLoS One

Systemic sclerosis

2018-01-02

Transethnic meta-analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis.