Analysis of the genetic component of systemic sclerosis in Iranian and Turkish populations through a genome-wide association study.
González-Serna D, López-Isac E, Yilmaz N et al.
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Abstract
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Objectives: SSc is an autoimmune disease characterized by alteration of the immune response, vasculopathy and fibrosis. Most genetic studies on SSc have been performed in European-ancestry populations. The aim of this study was to analyse the genetic component of SSc in Middle Eastern patients from Iran and Turkey through a genome-wide association study.
764 Middle Eastern ancestry cases, 1,343 Middle Eastern ancestry controls
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