Active: Type 1 diabetes Clear all

GWAS 2026-02-20

Sex specific genomic insights into type 1 diabetes through GWAS and single cell transcriptome analysis.

Qu HQ

Diabetes Res Clin Pract

Type 1 diabetes x sex interaction

18949

Participants

N/A

Studies

Details PubMed

GWAS 2025-06-26

A type 1 diabetes genetic risk score discriminates between type 1 diabetes and type 2 diabetes in a Chinese population.

Hu J, Jiang G et al.

Diabetologia

Aims/hypothesis: We aimed to generate a population-specific type 1 diabetes genetic risk score (GRS)...

Type 1 diabetes

Replicated

137980

Participants

N/A

Studies

Details PubMed

GWAS 2025-05-05

Genome-Wide Association Study of Quantitative Kidney Function in 52,531 Individuals with Diabetes Identifies Five Diabetes-Specific Loci.

Cole JB, Dahlström EH et al.

J Am Soc Nephrol

Abstract Key Points: Comprehensive genome-wide association study of eGFR in diabetes, accounting for...

eGFR in diabetes mellitus (loose) kidney disease cases (minimal adjustment)

5064

Participants

N/A

Studies

Details PubMed

GWAS 2025-01-02

Genome-wide characterization of 54 urinary metabolites reveals molecular impact of kidney function.

Valo E, Richmond A et al.

Nat Commun

Dissecting the genetic mechanisms underlying urinary metabolite concentrations can provide molecular...

Urinary acetate to urinary creatinine ratio

7998

Participants

N/A

Studies

Details PubMed

GWAS 2025-01-01

Bayesian Effect Size Ranking to Prioritise Genetic Risk Variants in Common Diseases for Follow-Up Studies.

Crouch DJM, Inshaw JRJ et al.

Genet Epidemiol

Biological datasets often consist of thousands or millions of variables, e.g. genetic variants or bi...

Type 1 diabetes

173981

Participants

N/A

Studies

Details PubMed

GWAS 2024-11-18

Genetics of C-peptide and Age at Diagnosis in Type 1 Diabetes.

Roshandel D, Spiliopoulou A et al.

Diabetes

Identified genetic loci for C-peptide and type 1 diabetes (T1D) age at diagnosis (AAD) explain only ...

C-peptide levels in type I diabetes

7252

Participants

N/A

Studies

Details PubMed

GWAS 2024-06-11

Whole-genome sequencing identifies variants in ANK1, LRRN1, HAS1, and other genes and regulatory regions for stroke in type 1 diabetes.

Antikainen AA, Haukka JK et al.

Sci Rep

Individuals with type 1 diabetes (T1D) carry a markedly increased risk of stroke, with distinct clin...

Stroke in type 1 diabetes

Replicated

4996

Participants

N/A

Studies

Details PubMed

GWAS 2024-03-07

A multi-ancestry genome-wide association study in type 1 diabetes.

Michalek DA, Tern C et al.

Hum Mol Genet

Type 1 diabetes (T1D) is an autoimmune disease caused by destruction of the pancreatic β-cells. Geno...

Type 1 diabetes

308

Participants

N/A

Studies

Details PubMed

GWAS 2023-05-04

Genome-wide aggregated trans-effects on risk of type 1 diabetes: A test of the "omnigenic" sparse effector hypothesis of complex trait genetics.

Iakovliev A, McGurnaghan SJ et al.

Am J Hum Genet

The "omnigenic" hypothesis postulates that the polygenic effects of common SNPs on a typical complex...

Type 1 diabetes

12461

Participants

N/A

Studies

Details PubMed

GWAS 2023-03-13

Integrated glycomics and genetics analyses reveal a potential role for N-glycosylation of plasma proteins and IgGs, as well as the complement system, in the development of type 1 diabetes.

Rudman N, Kaur S et al.

Diabetologia

Aims/hypothesis: We previously demonstrated that N-glycosylation of plasma proteins and IgGs is diff...

Plasma protein N-glycan peak 29 levels in type 1 diabetes

Replicated

1529

Participants

N/A

Studies

Details PubMed

GWAS 2023-02-01

Genome-wide association study of the age of onset of type 1 diabetes reveals HTATIP2 as a novel T cell regulator.

Cardinale CJ, Chang X et al.

Front Immunol

Introduction: Type 1 diabetes, a disorder caused by autoimmune destruction of pancreatic insulin-pro...

Type 1 diabetes (age at diagnosis)

Replicated

4507

Participants

N/A

Studies

Details PubMed

GWAS 2022-05-12

Genetic Variants Associated with Neuropeptide Y Autoantibody Levels in Newly Diagnosed Individuals with Type 1 Diabetes.

Mansachs SJ, Villumsen SO et al.

Genes (Basel)

(1) Autoantibodies to the leucine variant of neuropeptide Y (NPY-LA) have been found in individuals ...

Neuropeptide Y autoantibody levels in type 1 diabetes

546

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Sex specific genomic insights into type 1 diabetes through GWAS and single cell transcriptome analysis.

Qu HQ

Diabetes Res Clin Pract

Type 1 diabetes x sex interaction

2026-02-20

A type 1 diabetes genetic risk score discriminates between type 1 diabetes and type 2 diabetes in a Chinese population.

Hu J, Jiang G et al.

Diabetologia

Type 1 diabetes

2025-06-26

Genome-Wide Association Study of Quantitative Kidney Function in 52,531 Individuals with Diabetes Identifies Five Diabetes-Specific Loci.

Cole JB, Dahlström EH et al.

J Am Soc Nephrol

eGFR in diabetes mellitus (loose) kidney disease cases (minimal adjustment)

2025-05-05

Genome-wide characterization of 54 urinary metabolites reveals molecular impact of kidney function.

Valo E, Richmond A et al.

Nat Commun

Urinary acetate to urinary creatinine ratio

2025-01-02

Bayesian Effect Size Ranking to Prioritise Genetic Risk Variants in Common Diseases for Follow-Up Studies.

Crouch DJM, Inshaw JRJ et al.

Genet Epidemiol

Type 1 diabetes

2025-01-01

Genetics of C-peptide and Age at Diagnosis in Type 1 Diabetes.

Roshandel D, Spiliopoulou A et al.

Diabetes

C-peptide levels in type I diabetes

2024-11-18

Whole-genome sequencing identifies variants in ANK1, LRRN1, HAS1, and other genes and regulatory regions for stroke in type 1 diabetes.

Antikainen AA, Haukka JK et al.

Sci Rep

Stroke in type 1 diabetes

2024-06-11

A multi-ancestry genome-wide association study in type 1 diabetes.

Michalek DA, Tern C et al.

Hum Mol Genet

Type 1 diabetes

2024-03-07

Genome-wide aggregated trans-effects on risk of type 1 diabetes: A test of the "omnigenic" sparse effector hypothesis of complex trait genetics.

Iakovliev A, McGurnaghan SJ et al.

Am J Hum Genet

Type 1 diabetes

2023-05-04

Integrated glycomics and genetics analyses reveal a potential role for N-glycosylation of plasma proteins and IgGs, as well as the complement system, in the development of type 1 diabetes.

Rudman N, Kaur S et al.

Diabetologia

Plasma protein N-glycan peak 29 levels in type 1 diabetes

2023-03-13

Genome-wide association study of the age of onset of type 1 diabetes reveals HTATIP2 as a novel T cell regulator.

Cardinale CJ, Chang X et al.

Front Immunol

Type 1 diabetes (age at diagnosis)

2023-02-01

Genetic Variants Associated with Neuropeptide Y Autoantibody Levels in Newly Diagnosed Individuals with Type 1 Diabetes.

Mansachs SJ, Villumsen SO et al.

Genes (Basel)

Neuropeptide Y autoantibody levels in type 1 diabetes

2022-05-12