Genome-wide association study of the age of onset of type 1 diabetes reveals HTATIP2 as a novel T cell regulator.
Cardinale CJ, Chang X, Wei Z et al.
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Introduction: Type 1 diabetes, a disorder caused by autoimmune destruction of pancreatic insulin-producing cells, is more difficult to manage when it presents at a younger age. We sought to identify genetic correlates of the age of onset by conducting the first genome-wide association study (GWAS) treating the age of first diagnosis as a quantitative trait.
4,014 European ancestry cases
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