Active: Am J Psychiatry Clear all

GWAS 2023-10-01

GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors.

Docherty AR, Mullins N et al.

Am J Psychiatry

Objective: Suicidal behavior is heritable and is a major cause of death worldwide. Two large-scale g...

Suicide attempt

815178

Participants

N/A

Studies

Details PubMed

GWAS 2023-06-07

Genetic Underpinnings of the Transition From Alcohol Consumption to Alcohol Use Disorder: Shared and Unique Genetic Architectures in a Cross-Ancestry Sample.

Kember RL, Vickers-Smith R et al.

Am J Psychiatry

Objective: Recent genome-wide association studies (GWASs) of alcohol-related phenotypes have uncover...

Alcohol use disorder

393879

Participants

N/A

Studies

Details PubMed

GWAS 2023-04-01

Genetic Associations Between Stress-Related Disorders and Autoimmune Disease.

Zeng Y, Suo C et al.

Am J Psychiatry

Objective: Emerging evidence supports a bidirectional phenotypic association between stress-related ...

Autoimmune disease

376871

Participants

N/A

Studies

Details PubMed

GWAS 2021-06-22

Genetic, Clinical, and Sociodemographic Factors Associated With Stimulant Treatment Outcomes in ADHD.

Brikell I, Wimberley T et al.

Am J Psychiatry

Objective: Stimulant medications are effective for treating attention deficit hyperactivity disorder...

Stimulant treatment initiation in ADHD

8953

Participants

N/A

Studies

Details PubMed

GWAS 2020-10-01

Genome-Wide Association Study of Suicide Death and Polygenic Prediction of Clinical Antecedents.

Docherty AR, Shabalin AA et al.

Am J Psychiatry

Objective: Death by suicide is a highly preventable yet growing worldwide health crisis. To date, th...

Suicide

18223

Participants

N/A

Studies

Details PubMed

GWAS 2020-01-07

Reproducible Genetic Risk Loci for Anxiety: Results From ∼200,000 Participants in the Million Veteran Program.

Levey DF, Gelernter J et al.

Am J Psychiatry

Objective: Anxiety disorders are common and often disabling. The goal of this study was to examine t...

Anxiety

199611

Participants

N/A

Studies

Details PubMed

GWAS 2019-06-05

GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores.

Mullins N, Bigdeli TB et al.

Am J Psychiatry

Objective: More than 90% of people who attempt suicide have a psychiatric diagnosis; however, twin a...

Suicide attempts in major depressive disorder

Replicated

10408

Participants

N/A

Studies

Details PubMed

GWAS 2019-03-29

Pharmacogenomic Variants and Drug Interactions Identified Through the Genetic Analysis of Clozapine Metabolism.

Pardiñas AF, Nalmpanti M et al.

Am J Psychiatry

Objective: Clozapine is the only effective medication for treatment-resistant schizophrenia, but its...

Plasma norclozapine levels in treatment-resistant schizophrenia

2989

Participants

N/A

Studies

Details PubMed

GWAS 2019-03-01

Genetic Markers of ADHD-Related Variations in Intracranial Volume.

Klein M, Walters RK et al.

Am J Psychiatry

Objective: Attention deficit hyperactivity disorder (ADHD) is a common and highly heritable neurodev...

Attention deficit hyperactivity disorder or hippocampal volume (pleiotropy)

80078

Participants

N/A

Studies

Details PubMed

GWAS 2019-03-01

Interrogating the Genetic Determinants of Tourette's Syndrome and Other Tic Disorders Through Genome-Wide Association Studies.

Yu D, Sul JH et al.

Am J Psychiatry

Objective: Tourette's syndrome is polygenic and highly heritable. Genome-wide association study (GWA...

Tourette syndrome

Replicated

21081

Participants

N/A

Studies

Details PubMed

GWAS 2018-10-19

Genome-Wide Association Study Meta-Analysis of the Alcohol Use Disorders Identification Test (AUDIT) in Two Population-Based Cohorts.

Sanchez-Roige S, Palmer AA et al.

Am J Psychiatry

Objective: Alcohol use disorders are common conditions that have enormous social and economic conseq...

Alcohol use disorder (total score)

141932

Participants

N/A

Studies

Details PubMed

GWAS 2018-03-02

Molecular Genetic Analysis Subdivided by Adversity Exposure Suggests Etiologic Heterogeneity in Major Depression.

Peterson RE, Cai N et al.

Am J Psychiatry

Objective: The extent to which major depression is the outcome of a single biological mechanism or r...

Major depressive disorder

9599

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors.

Docherty AR, Mullins N et al.

Am J Psychiatry

Suicide attempt

2023-10-01

Genetic Underpinnings of the Transition From Alcohol Consumption to Alcohol Use Disorder: Shared and Unique Genetic Architectures in a Cross-Ancestry Sample.

Kember RL, Vickers-Smith R et al.

Am J Psychiatry

Alcohol use disorder

2023-06-07

Genetic Associations Between Stress-Related Disorders and Autoimmune Disease.

Zeng Y, Suo C et al.

Am J Psychiatry

Autoimmune disease

2023-04-01

Genetic, Clinical, and Sociodemographic Factors Associated With Stimulant Treatment Outcomes in ADHD.

Brikell I, Wimberley T et al.

Am J Psychiatry

Stimulant treatment initiation in ADHD

2021-06-22

Genome-Wide Association Study of Suicide Death and Polygenic Prediction of Clinical Antecedents.

Docherty AR, Shabalin AA et al.

Am J Psychiatry

Suicide

2020-10-01

Reproducible Genetic Risk Loci for Anxiety: Results From ∼200,000 Participants in the Million Veteran Program.

Levey DF, Gelernter J et al.

Am J Psychiatry

Anxiety

2020-01-07

GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores.

Mullins N, Bigdeli TB et al.

Am J Psychiatry

Suicide attempts in major depressive disorder

2019-06-05

Pharmacogenomic Variants and Drug Interactions Identified Through the Genetic Analysis of Clozapine Metabolism.

Pardiñas AF, Nalmpanti M et al.

Am J Psychiatry

Plasma norclozapine levels in treatment-resistant schizophrenia

2019-03-29

Genetic Markers of ADHD-Related Variations in Intracranial Volume.

Klein M, Walters RK et al.

Am J Psychiatry

Attention deficit hyperactivity disorder or hippocampal volume (pleiotropy)

2019-03-01

Interrogating the Genetic Determinants of Tourette's Syndrome and Other Tic Disorders Through Genome-Wide Association Studies.

Yu D, Sul JH et al.

Am J Psychiatry

Tourette syndrome

2019-03-01

Genome-Wide Association Study Meta-Analysis of the Alcohol Use Disorders Identification Test (AUDIT) in Two Population-Based Cohorts.

Sanchez-Roige S, Palmer AA et al.

Am J Psychiatry

Alcohol use disorder (total score)

2018-10-19

Molecular Genetic Analysis Subdivided by Adversity Exposure Suggests Etiologic Heterogeneity in Major Depression.

Peterson RE, Cai N et al.

Am J Psychiatry

Major depressive disorder

2018-03-02