Genetic Markers of ADHD-Related Variations in Intracranial Volume.
Klein M, Walters RK, Demontis D et al.
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Abstract
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Objective: Attention deficit hyperactivity disorder (ADHD) is a common and highly heritable neurodevelopmental disorder with a complex pathophysiology. Intracranial volume (ICV) and volumes of the nucleus accumbens, amygdala, caudate nucleus, hippocampus, and putamen are smaller in people with ADHD compared with healthy individuals. The authors investigated the overlap between common genetic variation associated with ADHD risk and these brain volume measures to identify underlying biological processes contributing to the disorder.
19,099 European ancestry ADHD cases, 1,084 ADHD cases, 34,194 European ancestry controls, 997 controls, 24,704 European ancestry individuals
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