Active: Am J Respir Crit Care Med Clear all

GWAS 2024-03-12

Shared and Distinct Genomics of Chronic Thromboembolic Pulmonary Hypertension and Pulmonary Embolism.

Liley J, Newnham M et al.

Am J Respir Crit Care Med

Rationale: Chronic thromboembolic pulmonary hypertension involves the formation and nonresolution of...

Chronic thromboembolic pulmonary hypertension

12264

Participants

N/A

Studies

Details PubMed

GWAS 2023-05-11

A Large-Scale Exome-Wide Association Study Identifies Novel Germline Mutations in Lung Cancer.

Shen S, Li Z et al.

Am J Respir Crit Care Med

Rationale: Genome-wide association studies have identified common variants of lung cancer. However, ...

Adenocarcinoma

Replicated

664374

Participants

N/A

Studies

Details PubMed

GWAS 2023-03-15

Genetic Modifiers of Cystic Fibrosis Lung Disease Severity: Whole Genome Analysis of 7,840 Patients.

Zhou YH, Gallins PJ et al.

Am J Respir Crit Care Med

Rationale: Lung disease is the major cause of morbidity and mortality in persons with cystic fibrosi...

Lung disease severity in cystic fibrosis with pancreatic insufficiency

7840

Participants

N/A

Studies

Details PubMed

GWAS 2023-02-13

PCSK6 and Survival in Idiopathic Pulmonary Fibrosis.

Oldham JM, Allen RJ et al.

Am J Respir Crit Care Med

Rationale: Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by limited tre...

Transplantation-free survival in idiopathic pulmonary fibrosis

Replicated

1878

Participants

N/A

Studies

Details PubMed

GWAS 2023-01-05

Identification of a Genetic Susceptibility Locus for Idiopathic Pulmonary Fibrosis in the 16p Subtelomere Using Whole Genome Sequencing.

Donoghue LJ, Stockwell AD et al.

Am J Respir Crit Care Med

No abstract available

Idiopathic pulmonary fibrosis

9585

Participants

N/A

Studies

Details PubMed

GWAS 2022-07-12

Genome-Wide Association Study of Obstructive Sleep Apnea and Objective Sleep-Related Traits Identifies Novel Risk Loci in Han Chinese Individuals.

Xu H, Liu F et al.

Am J Respir Crit Care Med

Rationale: Previous genetic studies of obstructive sleep apnea (OSA) have limitations in terms of pr...

Obstructive sleep apnea

20590

Participants

N/A

Studies

Details PubMed

GWAS 2019-11-11

Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis.

Allen RJ, Guillen-Guio B et al.

Am J Respir Crit Care Med

Rationale: Idiopathic pulmonary fibrosis (IPF) is a complex lung disease characterized by scarring o...

Idiopathic pulmonary fibrosis

Replicated

24589

Participants

N/A

Studies

Details PubMed

GWAS 2019-07-24

Overlap of Genetic Risk Between Interstitial Lung Abnormalities and Idiopathic Pulmonary Fibrosis.

Hobbs BD, Putman RK et al.

Am J Respir Crit Care Med

Rationale: Interstitial lung abnormalities (ILAs) are associated with the highest genetic risk locus...

Subpleural-predominant interstitial lung abnormalities

10709

Participants

N/A

Studies

Details PubMed

GWAS 2018-09-10

Omega-3 Fatty Acids and Genome-wide Interaction Analyses Reveal DPP10-Pulmonary Function Association.

Xu J, Gaddis NC et al.

Am J Respir Crit Care Med

Rationale: Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have anti-inflammatory properties that co...

Pulmonary function (FEV1) x omega-3 PUFA (docosapentaenoic acid) interaction (2df)

Replicated

13649

Participants

N/A

Studies

Details PubMed

GWAS 2018-02-09

Genome Wide Association Study in African Americans with Acute Respiratory Distress Syndrome Identifies the Selectin P Ligand Gene as a Risk Factor.

Bime C, Pouladi N et al.

Am J Respir Crit Care Med

Rationale: Genetic factors are involved in acute respiratory distress syndrome (ARDS) susceptibility...

Acute respiratory distress syndrome

Replicated

1363

Participants

N/A

Studies

Details PubMed

GWAS 2018-02-02

A Genome-wide Association Study in Hispanics/Latinos Identifies Novel Signals for Lung Function. The Hispanic Community Health Study/Study of Latinos.

Burkart KM, Sofer T et al.

Am J Respir Crit Care Med

Rationale: Lung function and chronic obstructive pulmonary disease (COPD) are heritable traits. Geno...

FEV1

Replicated

111472

Participants

N/A

Studies

Details PubMed

GWAS 2016-11-30

Genome-Wide Interaction Analysis of Air Pollution Exposure and Childhood Asthma with Functional Follow-up.

Gref A, Merid SK et al.

Am J Respir Crit Care Med

Rationale: The evidence supporting an association between traffic-related air pollution exposure and...

Childhood onset asthma (traffic air pollution exposure interaction)

Replicated

3322

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Shared and Distinct Genomics of Chronic Thromboembolic Pulmonary Hypertension and Pulmonary Embolism.

Liley J, Newnham M et al.

Am J Respir Crit Care Med

Chronic thromboembolic pulmonary hypertension

2024-03-12

A Large-Scale Exome-Wide Association Study Identifies Novel Germline Mutations in Lung Cancer.

Shen S, Li Z et al.

Am J Respir Crit Care Med

Adenocarcinoma

2023-05-11

Genetic Modifiers of Cystic Fibrosis Lung Disease Severity: Whole Genome Analysis of 7,840 Patients.

Zhou YH, Gallins PJ et al.

Am J Respir Crit Care Med

Lung disease severity in cystic fibrosis with pancreatic insufficiency

2023-03-15

PCSK6 and Survival in Idiopathic Pulmonary Fibrosis.

Oldham JM, Allen RJ et al.

Am J Respir Crit Care Med

Transplantation-free survival in idiopathic pulmonary fibrosis

2023-02-13

Identification of a Genetic Susceptibility Locus for Idiopathic Pulmonary Fibrosis in the 16p Subtelomere Using Whole Genome Sequencing.

Donoghue LJ, Stockwell AD et al.

Am J Respir Crit Care Med

Idiopathic pulmonary fibrosis

2023-01-05

Genome-Wide Association Study of Obstructive Sleep Apnea and Objective Sleep-Related Traits Identifies Novel Risk Loci in Han Chinese Individuals.

Xu H, Liu F et al.

Am J Respir Crit Care Med

Obstructive sleep apnea

2022-07-12

Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis.

Allen RJ, Guillen-Guio B et al.

Am J Respir Crit Care Med

Idiopathic pulmonary fibrosis

2019-11-11

Overlap of Genetic Risk Between Interstitial Lung Abnormalities and Idiopathic Pulmonary Fibrosis.

Hobbs BD, Putman RK et al.

Am J Respir Crit Care Med

Subpleural-predominant interstitial lung abnormalities

2019-07-24

Omega-3 Fatty Acids and Genome-wide Interaction Analyses Reveal DPP10-Pulmonary Function Association.

Xu J, Gaddis NC et al.

Am J Respir Crit Care Med

Pulmonary function (FEV1) x omega-3 PUFA (docosapentaenoic acid) interaction (2df)

2018-09-10

Genome Wide Association Study in African Americans with Acute Respiratory Distress Syndrome Identifies the Selectin P Ligand Gene as a Risk Factor.

Bime C, Pouladi N et al.

Am J Respir Crit Care Med

Acute respiratory distress syndrome

2018-02-09

A Genome-wide Association Study in Hispanics/Latinos Identifies Novel Signals for Lung Function. The Hispanic Community Health Study/Study of Latinos.

Burkart KM, Sofer T et al.

Am J Respir Crit Care Med

FEV1

2018-02-02

Genome-Wide Interaction Analysis of Air Pollution Exposure and Childhood Asthma with Functional Follow-up.

Gref A, Merid SK et al.

Am J Respir Crit Care Med

Childhood onset asthma (traffic air pollution exposure interaction)

2016-11-30