Active: Bone Clear all

GWAS 2019-11-29

Genetic variants affecting bone mineral density and bone mineral content at multiple skeletal sites in Hispanic children.

Hou R, Cole SA et al.

Bone

Context: Osteoporosis is a major public health burden with significant economic costs. However, the ...

Bone mineral content

1030

Participants

N/A

Studies

Details PubMed

GWAS 2018-08-30

Identification of novel variants associated with osteoporosis, type 2 diabetes and potentially pleiotropic loci using pleiotropic cFDR method.

Hu Y, Tan LJ et al.

Bone

Aims: Clinical and epidemiological findings point to an association between type 2 diabetes (T2D) an...

Femoral neck bone mineral density or type 2 diabetes (pleiotropy)

212444

Participants

N/A

Studies

Details PubMed

GWAS 2018-08-30

Assessing the genetic correlations between early growth parameters and bone mineral density: A polygenic risk score analysis.

Liang X, Wu C et al.

Bone

Objective: The relationships between early growth parameters and bone mineral density (BMD) remain e...

Total body bone mineral density

2286

Participants

N/A

Studies

Details PubMed

GWAS 2018-06-05

Genome-wide association study of extreme high bone mass: Contribution of common genetic variation to extreme BMD phenotypes and potential novel BMD-associated genes.

Gregson CL, Newell F et al.

Bone

Generalised high bone mass (HBM), associated with features of a mild skeletal dysplasia, has a preva...

Bone mineral density (total hip)

Replicated

2110

Participants

N/A

Studies

Details PubMed

GWAS 2018-02-27

Joint study of two genome-wide association meta-analyses identified 20p12.1 and 20q13.33 for bone mineral density.

Pei YF, Hu WZ et al.

Bone

In the present study, aiming to identify loci associated with osteoporosis, we conducted a joint ass...

Femoral neck bone mineral density

40491

Participants

N/A

Studies

Details PubMed

GWAS 2017-06-23

Genetic sharing with coronary artery disease identifies potential novel loci for bone mineral density.

Peng C, Shen J et al.

Bone

Bone mineral density (BMD) is a complex trait with high missing heritability. Numerous evidences hav...

Lumbar spine bone mineral density or coronary artery disease (pleiotropy)

140231

Participants

N/A

Studies

Details PubMed

GWAS 2016-07-15

Genome-wide association study in East Asians suggests UHMK1 as a novel bone mineral density susceptibility gene.

Choi HJ, Park H et al.

Bone

To identify genetic variants that influence bone mineral density (BMD) in East Asians, we performed ...

Bone mineral density (femoral neck)

Replicated

7513

Participants

N/A

Studies

Details PubMed

GWAS 2016-07-07

Genome-wide association meta-analyses identified 1q43 and 2q32.2 for hip Ward's triangle areal bone mineral density.

Pei YF, Hu WZ et al.

Bone

Aiming to identify genomic variants associated with osteoporosis, we performed a genome-wide associa...

Bone mineral density (Ward's triangle area)

7175

Participants

N/A

Studies

Details PubMed

GWAS 2015-12-12

Meta analysis identifies a novel susceptibility locus associated with heel bone strength in the Korean population.

Hwang JY, Kim YJ et al.

Bone

Introduction: Calcaneal quantitative ultrasound has been recognized as a non-invasive method for eva...

Calcaneal bone ultrasound measurement (speed of sound)

Replicated

9158

Participants

N/A

Studies

Details PubMed

GWAS 2013-10-25

Genome-wide Association Study for Radiographic Vertebral Fractures: A Potential Role for the 16q24 BMD Locus versus Lessons Learned from Challenging Phenotype Definition.

Oei L, Estrada K et al.

Bone

Vertebral fracture risk is a heritable complex trait. The aim of this study was to identify genetic ...

Fractures (vertebral)

Replicated

30506

Participants

N/A

Studies

Details PubMed

GWAS 2012-11-30

Genome-wide association study identified UQCC locus for spine bone size in humans.

Deng FY, Dong SS et al.

Bone

Bone size (BS) contributes significantly to the risk of osteoporotic fracture. Osteoporotic spine fr...

Spine bone size

Replicated

6416

Participants

N/A

Studies

Details PubMed

GWAS 2012-08-31

Bivariate genome-wide association study suggests fatty acid desaturase genes and cadherin DCHS2 for variation of both compressive strength index and appendicular lean mass in males.

Han Y, Pei Y et al.

Bone

Compressive strength index (CSI) is a newly established index for predicting hip fracture, the most ...

Comprehensive strength and appendicular lean mass

Replicated

4913

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genetic variants affecting bone mineral density and bone mineral content at multiple skeletal sites in Hispanic children.

Hou R, Cole SA et al.

Bone

Bone mineral content

2019-11-29

Identification of novel variants associated with osteoporosis, type 2 diabetes and potentially pleiotropic loci using pleiotropic cFDR method.

Hu Y, Tan LJ et al.

Bone

Femoral neck bone mineral density or type 2 diabetes (pleiotropy)

2018-08-30

Assessing the genetic correlations between early growth parameters and bone mineral density: A polygenic risk score analysis.

Liang X, Wu C et al.

Bone

Total body bone mineral density

2018-08-30

Genome-wide association study of extreme high bone mass: Contribution of common genetic variation to extreme BMD phenotypes and potential novel BMD-associated genes.

Gregson CL, Newell F et al.

Bone

Bone mineral density (total hip)

2018-06-05

Joint study of two genome-wide association meta-analyses identified 20p12.1 and 20q13.33 for bone mineral density.

Pei YF, Hu WZ et al.

Bone

Femoral neck bone mineral density

2018-02-27

Genetic sharing with coronary artery disease identifies potential novel loci for bone mineral density.

Peng C, Shen J et al.

Bone

Lumbar spine bone mineral density or coronary artery disease (pleiotropy)

2017-06-23

Genome-wide association study in East Asians suggests UHMK1 as a novel bone mineral density susceptibility gene.

Choi HJ, Park H et al.

Bone

Bone mineral density (femoral neck)

2016-07-15

Genome-wide association meta-analyses identified 1q43 and 2q32.2 for hip Ward's triangle areal bone mineral density.

Pei YF, Hu WZ et al.

Bone

Bone mineral density (Ward's triangle area)

2016-07-07

Meta analysis identifies a novel susceptibility locus associated with heel bone strength in the Korean population.

Hwang JY, Kim YJ et al.

Bone

Calcaneal bone ultrasound measurement (speed of sound)

2015-12-12

Genome-wide Association Study for Radiographic Vertebral Fractures: A Potential Role for the 16q24 BMD Locus versus Lessons Learned from Challenging Phenotype Definition.

Oei L, Estrada K et al.

Bone

Fractures (vertebral)

2013-10-25

Genome-wide association study identified UQCC locus for spine bone size in humans.

Deng FY, Dong SS et al.

Bone

Spine bone size

2012-11-30

Bivariate genome-wide association study suggests fatty acid desaturase genes and cadherin DCHS2 for variation of both compressive strength index and appendicular lean mass in males.

Han Y, Pei Y et al.

Bone

Comprehensive strength and appendicular lean mass

2012-08-31