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GWAS Study

Identification of novel variants associated with osteoporosis, type 2 diabetes and potentially pleiotropic loci using pleiotropic cFDR method.

Hu Y, Tan LJ, Chen XD et al.

30172742 PubMed ID
GWAS Study Type
212444 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

HY
Hu Y
TL
Tan LJ
CX
Chen XD
GJ
Greenbaum J
DH
Deng HW
Chapter II

Abstract

Summary of the research findings

Aims: Clinical and epidemiological findings point to an association between type 2 diabetes (T2D) and osteoporosis. Genome-wide association studies (GWASs) have been fruitful in identifying some loci potentially associated with osteoporosis and T2D respectively. However, the total genetic variance for each of these two diseases and the shared genetic determination between them are largely unknown. The aim of this study was to identify novel genetic variants for osteoporosis and/or T2D.

53,236 European ancestry individuals with bone mineral density data, 26,676 European ancestry type 2 diabetes cases, 132,532 European ancestry controls

Chapter III

Study Statistics

Key metrics and study information

212444
Total Participants
GWAS
Study Type
No
Replicated
European
Ancestry
Chapter IV

AI-Generated Summary

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