Identification of novel variants associated with osteoporosis, type 2 diabetes and potentially pleiotropic loci using pleiotropic cFDR method.
Hu Y, Tan LJ, Chen XD et al.
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Abstract
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Aims: Clinical and epidemiological findings point to an association between type 2 diabetes (T2D) and osteoporosis. Genome-wide association studies (GWASs) have been fruitful in identifying some loci potentially associated with osteoporosis and T2D respectively. However, the total genetic variance for each of these two diseases and the shared genetic determination between them are largely unknown. The aim of this study was to identify novel genetic variants for osteoporosis and/or T2D.
53,236 European ancestry individuals with bone mineral density data, 26,676 European ancestry type 2 diabetes cases, 132,532 European ancestry controls
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