Active: J Clin Invest Clear all

GWAS 2022-10-04

Clinical, genetic, and experimental increase in soluble urokinase plasminogen activator receptor levels promotes atherosclerosis.

Hindy G, Tyrrell DJ et al.

J Clin Invest

People with kidney disease are disproportionately affected by atherosclerosis for unclear reasons. S...

Soluble urokinase plasminogen activator receptor levels

Replicated

25114

Participants

N/A

Studies

Details PubMed

GWAS 2021-05-20

Multi-ancestry genome-wide association study identifies 27 loci associated with measures of hemolysis following blood storage.

Page GP, Kanias T et al.

J Clin Invest

BackgroundThe evolutionary pressure of endemic malaria and other erythrocytic pathogens has shaped v...

hemolysis of donated blood (osmotic)

12219

Participants

N/A

Studies

Details PubMed

GWAS 2020-11-17

Congenital heart disease risk loci identified by genome-wide association study in European patients.

Lahm H, Jia M et al.

J Clin Invest

Genetic factors undoubtedly affect the development of congenital heart disease (CHD) but still remai...

Congenital heart disease

12520

Participants

N/A

Studies

Details PubMed

GWAS 2017-08-07

Phenotypic and pharmacogenetic evaluation of patients with thiazide-induced hyponatremia.

Ware JS, Wain LV et al.

J Clin Invest

Thiazide diuretics are among the most widely used treatments for hypertension, but thiazide-induced ...

Thiazide-induced hyponatremia

Replicated

3153

Participants

N/A

Studies

Details PubMed

GWAS 2017-04-10

Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function.

Wild PS, Felix JF et al.

J Clin Invest

Understanding the genetic architecture of cardiac structure and function may help to prevent and tre...

Peak velocity of the mitral E-wave

Replicated

36639

Participants

N/A

Studies

Details PubMed

GWAS 2015-03-23

Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene.

Knowles JW, Xie W et al.

J Clin Invest

Decreased insulin sensitivity, also referred to as insulin resistance (IR), is a fundamental abnorma...

Insulin resistance/response

Replicated

5624

Participants

N/A

Studies

Details PubMed

GWAS 2013-10-08

Lumbar disc degeneration is linked to a carbohydrate sulfotransferase 3 variant.

Song YQ, Karasugi T et al.

J Clin Invest

Lumbar disc degeneration (LDD) is associated with both genetic and environmental factors and affects...

Disc degeneration (lumbar)

Replicated

28228

Participants

N/A

Studies

Details PubMed

GWAS 2013-09-03

Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling.

Ho JE, Chen WY et al.

J Clin Invest

The suppression of tumorigenicity 2/IL-33 (ST2/IL-33) pathway has been implicated in several immune ...

Serum protein levels (sST2)

2797

Participants

N/A

Studies

Details PubMed

GWAS 2008-06-04

Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels.

Chen WM, Erdos MR et al.

J Clin Invest

Identifying the genetic variants that regulate fasting glucose concentrations may further our unders...

Fasting plasma glucose

Replicated

23524

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Clinical, genetic, and experimental increase in soluble urokinase plasminogen activator receptor levels promotes atherosclerosis.

Hindy G, Tyrrell DJ et al.

J Clin Invest

Soluble urokinase plasminogen activator receptor levels

2022-10-04

Multi-ancestry genome-wide association study identifies 27 loci associated with measures of hemolysis following blood storage.

Page GP, Kanias T et al.

J Clin Invest

hemolysis of donated blood (osmotic)

2021-05-20

Congenital heart disease risk loci identified by genome-wide association study in European patients.

Lahm H, Jia M et al.

J Clin Invest

Congenital heart disease

2020-11-17

Phenotypic and pharmacogenetic evaluation of patients with thiazide-induced hyponatremia.

Ware JS, Wain LV et al.

J Clin Invest

Thiazide-induced hyponatremia

2017-08-07

Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function.

Wild PS, Felix JF et al.

J Clin Invest

Peak velocity of the mitral E-wave

2017-04-10

Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene.

Knowles JW, Xie W et al.

J Clin Invest

Insulin resistance/response

2015-03-23

Lumbar disc degeneration is linked to a carbohydrate sulfotransferase 3 variant.

Song YQ, Karasugi T et al.

J Clin Invest

Disc degeneration (lumbar)

2013-10-08

Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling.

Ho JE, Chen WY et al.

J Clin Invest

Serum protein levels (sST2)

2013-09-03

Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels.

Chen WM, Erdos MR et al.

J Clin Invest

Fasting plasma glucose

2008-06-04