Active: J Clin Oncol Clear all

GWAS 2024-04-23

Trans-Ancestral Genetic Risk Factors for Treatment-Related Type 2 Diabetes Mellitus in Survivors of Childhood Cancer.

Im C, Neupane A et al.

J Clin Oncol

Purpose: Type 2 diabetes mellitus (T2D) is a prevalent long-term complication of treatment in surviv...

Type 2 diabetes in childhood cancer survivors

Replicated

9067

Participants

N/A

Studies

Details PubMed

GWAS 2022-12-12

Genome-Wide Association Study Identifies <i>ROBO2</i> as a Novel Susceptibility Gene for Anthracycline-Related Cardiomyopathy in Childhood Cancer Survivors.

Wang X, Singh P et al.

J Clin Oncol

Purpose: Interindividual variability in the dose-dependent association between anthracyclines and ca...

Cardiomyopathy in anthracycline-exposed childhood cancer survivors x anthracycline dose interaction

Replicated

2131

Participants

N/A

Studies

Details PubMed

GWAS 2016-04-25

Clinical and Genetic Risk Factors for Acute Pancreatitis in Patients With Acute Lymphoblastic Leukemia.

Liu C, Yang W et al.

J Clin Oncol

Purpose: Acute pancreatitis is one of the common causes of asparaginase intolerance. The mechanism i...

Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia

213

Participants

N/A

Studies

Details PubMed

GWAS 2016-01-25

CELF4 Variant and Anthracycline-Related Cardiomyopathy: A Children's Oncology Group Genome-Wide Association Study.

Wang X, Sun CL et al.

J Clin Oncol

Purpose: Interindividual variability in the dose-dependent association between anthracyclines and ca...

Cardiomyopathy in childhood cancer survivors (anthracycline treatment interaction)

Replicated

385

Participants

N/A

Studies

Details PubMed

GWAS 2015-10-12

Genome-Wide Association Study of Event-Free Survival in Diffuse Large B-Cell Lymphoma Treated With Immunochemotherapy.

Ghesquieres H, Slager SL et al.

J Clin Oncol

Purpose: We performed a multistage genome-wide association study to identify inherited genetic varia...

Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy

Replicated

1537

Participants

N/A

Studies

Details PubMed

GWAS 2011-01-24

HLA-DQA1*02:01 is a major risk factor for lapatinib-induced hepatotoxicity in women with advanced breast cancer.

Spraggs CF, Budde LR et al.

J Clin Oncol

Purpose: Hepatobiliary adverse events (AEs) have been observed in a small proportion of patients wit...

Lapatinib-induced hepatotoxicity in breast cancer

Replicated

502

Participants

N/A

Studies

Details PubMed

GWAS 2010-09-27

Genome-wide associations and functional genomic studies of musculoskeletal adverse events in women receiving aromatase inhibitors.

Ingle JN, Schaid DJ et al.

J Clin Oncol

Purpose: We performed a case-control genome-wide association study (GWAS) to identify single nucleot...

Adverse response to aromatase inhibitors

878

Participants

N/A

Studies

Details PubMed

GWAS 2009-11-09

Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.

Treviño LR, Shimasaki N et al.

J Clin Oncol

Purpose: Methotrexate plasma concentration is related to its clinical effects. Our aim was to identi...

Methotrexate pharmacokinetics (acute lymphoblastic leukemia)

640

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Trans-Ancestral Genetic Risk Factors for Treatment-Related Type 2 Diabetes Mellitus in Survivors of Childhood Cancer.

Im C, Neupane A et al.

J Clin Oncol

Type 2 diabetes in childhood cancer survivors

2024-04-23

Genome-Wide Association Study Identifies <i>ROBO2</i> as a Novel Susceptibility Gene for Anthracycline-Related Cardiomyopathy in Childhood Cancer Survivors.

Wang X, Singh P et al.

J Clin Oncol

Cardiomyopathy in anthracycline-exposed childhood cancer survivors x anthracycline dose interaction

2022-12-12

Clinical and Genetic Risk Factors for Acute Pancreatitis in Patients With Acute Lymphoblastic Leukemia.

Liu C, Yang W et al.

J Clin Oncol

Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia

2016-04-25

CELF4 Variant and Anthracycline-Related Cardiomyopathy: A Children's Oncology Group Genome-Wide Association Study.

Wang X, Sun CL et al.

J Clin Oncol

Cardiomyopathy in childhood cancer survivors (anthracycline treatment interaction)

2016-01-25

Genome-Wide Association Study of Event-Free Survival in Diffuse Large B-Cell Lymphoma Treated With Immunochemotherapy.

Ghesquieres H, Slager SL et al.

J Clin Oncol

Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy

2015-10-12

HLA-DQA1*02:01 is a major risk factor for lapatinib-induced hepatotoxicity in women with advanced breast cancer.

Spraggs CF, Budde LR et al.

J Clin Oncol

Lapatinib-induced hepatotoxicity in breast cancer

2011-01-24

Genome-wide associations and functional genomic studies of musculoskeletal adverse events in women receiving aromatase inhibitors.

Ingle JN, Schaid DJ et al.

J Clin Oncol

Adverse response to aromatase inhibitors

2010-09-27

Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.

Treviño LR, Shimasaki N et al.

J Clin Oncol

Methotrexate pharmacokinetics (acute lymphoblastic leukemia)

2009-11-09