Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.
Treviño LR, Shimasaki N, Yang W et al.
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Abstract
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Purpose: Methotrexate plasma concentration is related to its clinical effects. Our aim was to identify the genetic basis of interindividual variability in methotrexate pharmacokinetics in children with newly diagnosed acute lymphoblastic leukemia (ALL).
315 European ancestry cases, 73 African American cases, 5 Asian ancestry cases, 247 cases
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