Active: J Gerontol A Biol Sci Med Sci Clear all

GWAS 2025-10-01

A genome-wide association study identified 10 novel genomic loci associated with intrinsic capacity.

Beyene MB, Visvanathan R et al.

J Gerontol A Biol Sci Med Sci

Intrinsic capacity (IC) is a multidimensional concept within the World Health Organization framework...

Intrinsic capacity

44631

Participants

N/A

Studies

Details PubMed

GWAS 2024-06-14

GWAS identifies DPP6 as risk gene of cognitive decline in Parkinson's disease.

Li C, Hou Y et al.

J Gerontol A Biol Sci Med Sci

Cognitive decline is among the most common non-motor symptoms in Parkinson's disease (PD), while its...

Cognitive performance in Parkinson's disease

1529

Participants

N/A

Studies

Details PubMed

GWAS 2022-02-18

Genetic pleiotropy between pulmonary function and age-related traits: The Long Life Family Study.

Feitosa MF, Wojczynski MK et al.

J Gerontol A Biol Sci Med Sci

Pulmonary function (PF) progressively declines with aging. Forced expiratory volume in the first sec...

Forced vital capacity and interleukin-6 levels and high-sensitivity C-reactive protein levels (pleiotropy)

6229

Participants

N/A

Studies

Details PubMed

GWAS 2021-08-24

Lifestyle factors and genetic variants on two biological age measures: evidence from 94,443 Taiwan Biobank participants.

Lin WY

J Gerontol A Biol Sci Med Sci

Biological age (BA) can be estimated by phenotypes and is useful for predicting life span and health...

Biological age (BioAge)

Replicated

94443

Participants

N/A

Studies

Details PubMed

GWAS 2021-01-25

Exome-wide association study identifies FN3KRP and PGP as new candidate longevity genes.

Torres GG, Nygaard M et al.

J Gerontol A Biol Sci Med Sci

Despite enormous research efforts, the genetic component of longevity has remained largely elusive. ...

Longevity

Replicated

13023

Participants

N/A

Studies

Details PubMed

GWAS 2019-09-30

Quantitative and qualitative role of antagonistic heterogeneity in genetics of blood lipids.

Kulminski AM, Loika Y et al.

J Gerontol A Biol Sci Med Sci

Prevailing strategies in genome-wide association studies (GWAS) mostly rely on principles of medical...

High density lipoprotein cholesterol levels

29902

Participants

N/A

Studies

Details PubMed

GWAS 2016-11-05

Genome-wide Association Study of Parental Life Span.

Tanaka T, Dutta A et al.

J Gerontol A Biol Sci Med Sci

Having longer lived parents has been shown to be an important predictor of health trajectories and l...

Parental longevity (at least one long-lived parent)

Replicated

7666

Participants

N/A

Studies

Details PubMed

GWAS 2015-07-28

Heritability and Genome-Wide Association Analyses of Human Gait Suggest Contribution of Common Variants.

Adams HH, Verlinden VJ et al.

J Gerontol A Biol Sci Med Sci

Human gait is a complex neurological and musculoskeletal function, of which the genetic basis remain...

Gait variability

2946

Participants

N/A

Studies

Details PubMed

GWAS 2014-09-08

GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy.

Broer L, Buchman AS et al.

J Gerontol A Biol Sci Med Sci

The genetic contribution to longevity in humans has been estimated to range from 15% to 25%. Only tw...

Longevity (90 years and older)

9793

Participants

N/A

Studies

Details PubMed

GWAS 2010-03-18

A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium.

Newman AB, Walter S et al.

J Gerontol A Biol Sci Med Sci

Genome-wide association studies (GWAS) may yield insights into longevity.

Longevity

Replicated

9816

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

A genome-wide association study identified 10 novel genomic loci associated with intrinsic capacity.

Beyene MB, Visvanathan R et al.

J Gerontol A Biol Sci Med Sci

Intrinsic capacity

2025-10-01

GWAS identifies DPP6 as risk gene of cognitive decline in Parkinson's disease.

Li C, Hou Y et al.

J Gerontol A Biol Sci Med Sci

Cognitive performance in Parkinson's disease

2024-06-14

Genetic pleiotropy between pulmonary function and age-related traits: The Long Life Family Study.

Feitosa MF, Wojczynski MK et al.

J Gerontol A Biol Sci Med Sci

Forced vital capacity and interleukin-6 levels and high-sensitivity C-reactive protein levels (pleiotropy)

2022-02-18

Lifestyle factors and genetic variants on two biological age measures: evidence from 94,443 Taiwan Biobank participants.

Lin WY

J Gerontol A Biol Sci Med Sci

Biological age (BioAge)

2021-08-24

Exome-wide association study identifies FN3KRP and PGP as new candidate longevity genes.

Torres GG, Nygaard M et al.

J Gerontol A Biol Sci Med Sci

Longevity

2021-01-25

Quantitative and qualitative role of antagonistic heterogeneity in genetics of blood lipids.

Kulminski AM, Loika Y et al.

J Gerontol A Biol Sci Med Sci

High density lipoprotein cholesterol levels

2019-09-30

Genome-wide Association Study of Parental Life Span.

Tanaka T, Dutta A et al.

J Gerontol A Biol Sci Med Sci

Parental longevity (at least one long-lived parent)

2016-11-05

Heritability and Genome-Wide Association Analyses of Human Gait Suggest Contribution of Common Variants.

Adams HH, Verlinden VJ et al.

J Gerontol A Biol Sci Med Sci

Gait variability

2015-07-28

GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy.

Broer L, Buchman AS et al.

J Gerontol A Biol Sci Med Sci

Longevity (90 years and older)

2014-09-08

A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium.

Newman AB, Walter S et al.

J Gerontol A Biol Sci Med Sci

Longevity

2010-03-18