Active: Adiposity Clear all

GWAS 2025-09-26

Genetic impact of central adiposity on systolic blood pressure in females: interaction and mediation by TG/HDL-C, HbA1c, and uric acid across BMI categories.

Gumilang RA, Bai CH

Int J Obes (Lond)

Genetic predisposition to central adiposity is associated with metabolic dysfunction and obesity-rel...

Waist circumference

49188

Participants

N/A

Studies

Details PubMed

GWAS 2025-08-13

Modeling the genomic architecture of adiposity and anthropometrics across the lifespan.

Arehart CH, Lin M et al.

Nat Commun

Obesity-related conditions are among the leading causes of preventable death and are increasing in p...

Adiposity (multivariate analysis)

393268

Participants

N/A

Studies

Details PubMed

GWAS 2025-07-01

Investigating the shared genetic architecture between adiposity measures and obesity-related cancers.

Wang S, Liu H et al.

Brief Bioinform

Fat distribution patterns are increasingly linked to obesity-related cancers; however, their shared ...

Leg fat ratio or ovarian cancer (pleiotropy)

127582

Participants

N/A

Studies

Details PubMed

GWAS 2024-09-14

Genome-wide discovery and integrative genomic characterization of insulin resistance loci using serum triglycerides to HDL-cholesterol ratio as a proxy.

DeForest N, Wang Y et al.

Nat Commun

Insulin resistance causes multiple epidemic metabolic diseases, including type 2 diabetes, cardiovas...

Triglyceride to HDL cholesterol ratio

Replicated

419674

Participants

N/A

Studies

Details PubMed

GWAS 2024-07-10

Characterising the genetic architecture of changes in adiposity during adulthood using electronic health records.

Venkatesh SS, Ganjgahi H et al.

Nat Commun

Obesity is a heritable disease, characterised by excess adiposity that is measured by body mass inde...

Change in body mass index over time

Replicated

210279

Participants

N/A

Studies

Details PubMed

GWAS 2024-07-07

Novel genomic variants related to visceral adiposity index (VAI) and body adiposity index (BAI) in Indian sib-pairs.

Agarwal T, Lyngdoh T et al.

Int J Obes (Lond)

Obesity is among the leading public health threats globally. Over the last few years, visceral adipo...

Visceral adiposity index (adjusted for BMI)

4530

Participants

N/A

Studies

Details PubMed

GWAS 2024-02-19

Genetic influences on circulating retinol and its relationship to human health.

Reay WR, Kiltschewskij DJ et al.

Nat Commun

Retinol is a fat-soluble vitamin that plays an essential role in many biological processes throughou...

Circulating retinol levels

Replicated

18903

Participants

N/A

Studies

Details PubMed

GWAS 2023-10-27

Genome-Wide Association Study of Pericardial Fat Area in 28 161 UK Biobank Participants.

Salih A, Ardissino M et al.

J Am Heart Assoc

BACKGROUND Pericardial adipose tissue (PAT) is the visceral adipose tissue compartment surrounding t...

Pericardial fat

28161

Participants

N/A

Studies

Details PubMed

GWAS 2023-10-05

Beyond apples and pears: sex-specific genetics of body fat percentage.

Roshandel D, Lu T et al.

Front Endocrinol (Lausanne)

Introduction: Biological sex influences both overall adiposity and fat distribution. Further, testos...

Body fat percentage (adjusted for testosterone and SHBG)

154337

Participants

N/A

Studies

Details PubMed

GWAS 2023-10-03

Central Adiposity Increases Risk of Kidney Stone Disease via Effects on Serum Calcium Concentrations.

Lovegrove CE, Bešević J et al.

J Am Soc Nephrol

Significance statement: Kidney stone disease is a common disorder with poorly understood pathophysio...

Kidney stone disease

739048

Participants

N/A

Studies

Details PubMed

GWAS 2023-07-03

Causal associations between cardiorespiratory fitness and type 2 diabetes.

Cai L, Gonzales T et al.

Nat Commun

Higher cardiorespiratory fitness is associated with lower risk of type 2 diabetes. However, the caus...

Cardiorespiratory fitness

69416

Participants

N/A

Studies

Details PubMed

GWAS 2023-01-31

New insights from GWAS on BMI-related growth traits in a longitudinal cohort of admixed children with Native American and European ancestry.

Vicuña L, Barrientos E et al.

iScience

Body-mass index (BMI) is a hallmark of adiposity. In contrast with adulthood, the genetic architectu...

Age at adiposity rebound x sex interaction

904

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genetic impact of central adiposity on systolic blood pressure in females: interaction and mediation by TG/HDL-C, HbA1c, and uric acid across BMI categories.

Gumilang RA, Bai CH

Int J Obes (Lond)

Waist circumference

2025-09-26

Modeling the genomic architecture of adiposity and anthropometrics across the lifespan.

Arehart CH, Lin M et al.

Nat Commun

Adiposity (multivariate analysis)

2025-08-13

Investigating the shared genetic architecture between adiposity measures and obesity-related cancers.

Wang S, Liu H et al.

Brief Bioinform

Leg fat ratio or ovarian cancer (pleiotropy)

2025-07-01

Genome-wide discovery and integrative genomic characterization of insulin resistance loci using serum triglycerides to HDL-cholesterol ratio as a proxy.

DeForest N, Wang Y et al.

Nat Commun

Triglyceride to HDL cholesterol ratio

2024-09-14

Characterising the genetic architecture of changes in adiposity during adulthood using electronic health records.

Venkatesh SS, Ganjgahi H et al.

Nat Commun

Change in body mass index over time

2024-07-10

Novel genomic variants related to visceral adiposity index (VAI) and body adiposity index (BAI) in Indian sib-pairs.

Agarwal T, Lyngdoh T et al.

Int J Obes (Lond)

Visceral adiposity index (adjusted for BMI)

2024-07-07

Genetic influences on circulating retinol and its relationship to human health.

Reay WR, Kiltschewskij DJ et al.

Nat Commun

Circulating retinol levels

2024-02-19

Genome-Wide Association Study of Pericardial Fat Area in 28 161 UK Biobank Participants.

Salih A, Ardissino M et al.

J Am Heart Assoc

Pericardial fat

2023-10-27

Beyond apples and pears: sex-specific genetics of body fat percentage.

Roshandel D, Lu T et al.

Front Endocrinol (Lausanne)

Body fat percentage (adjusted for testosterone and SHBG)

2023-10-05

Central Adiposity Increases Risk of Kidney Stone Disease via Effects on Serum Calcium Concentrations.

Lovegrove CE, Bešević J et al.

J Am Soc Nephrol

Kidney stone disease

2023-10-03

Causal associations between cardiorespiratory fitness and type 2 diabetes.

Cai L, Gonzales T et al.

Nat Commun

Cardiorespiratory fitness

2023-07-03

New insights from GWAS on BMI-related growth traits in a longitudinal cohort of admixed children with Native American and European ancestry.

Vicuña L, Barrientos E et al.

iScience

Age at adiposity rebound x sex interaction

2023-01-31