Central Adiposity Increases Risk of Kidney Stone Disease via Effects on Serum Calcium Concentrations.
Lovegrove CE, Bešević J, Wiberg A et al.
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Abstract
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Significance statement: Kidney stone disease is a common disorder with poorly understood pathophysiology. Observational and genetic studies indicate that adiposity is associated with an increased risk of kidney stone disease. However, the relative contribution of general and central adipose depots and the mechanisms by which effects of adiposity on kidney stone disease are mediated have not been defined. Using conventional and genetic epidemiological techniques, we demonstrate that general and central adiposity are independently associated with kidney stone disease. In addition, one mechanism by which central adiposity increases risk of kidney stone disease is by increasing serum calcium concentration. Therapies targeting adipose depots may affect calcium homeostasis and help to prevent kidney stone disease.
17,101 European ancestry cases, 721,947 European ancestry controls
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