Active: Amyotrophic lateral sclerosis Clear all

GWAS 2026-03-31

Large-scale exome analyses reveal new rare variant contributions in amyotrophic lateral sclerosis.

Hop PJ

Nat Genet

Amyotrophic lateral sclerosis

Replicated

218622

Participants

N/A

Studies

Details PubMed

GWAS 2025-12-05

A genome-wide association study identifies the GPM6A locus associated with age at onset in ALS.

Nakamura R

Commun Biol

Amyotrophic lateral sclerosis (age of onset)

2015

Participants

N/A

Studies

Details PubMed

GWAS 2023-09-28

Identifying risk loci for FTD and shared genetic component with ALS: A large-scale multitrait association analysis.

Chen K, Gao T et al.

Neurobiol Aging

Current genome-wide association studies of frontotemporal dementia (FTD) are underpowered due to lim...

Frontotemporal dementia (MTAG)

12928

Participants

N/A

Studies

Details PubMed

GWAS 2023-05-04

Genetic factors affecting survival in Japanese patients with sporadic amyotrophic lateral sclerosis: a genome-wide association study and verification in iPSC-derived motor neurons from patients.

Nakamura R

J Neurol Neurosurg Psychiatry

Survival in sporadic amyotrophic lateral sclerosis

1076

Participants

N/A

Studies

Details PubMed

GWAS 2021-12-06

Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology.

van Rheenen W, van der Spek RAA et al.

Nat Genet

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a lifetime risk of one...

Amyotrophic lateral sclerosis

152268

Participants

N/A

Studies

Details PubMed

GWAS 2021-09-02

Genome-wide association study of frontotemporal dementia identifies a C9ORF72 haplotype with a median of 12-G4C2 repeats that predisposes to pathological repeat expansions.

Reus LM, Jansen IE et al.

Transl Psychiatry

Genetic factors play a major role in frontotemporal dementia (FTD). The majority of FTD cannot be ge...

Frontotemporal dementia

Replicated

5462

Participants

N/A

Studies

Details PubMed

GWAS 2020-10-01

Genome-wide Meta-analysis Finds the ACSL5-ZDHHC6 Locus Is Associated with ALS and Links Weight Loss to the Disease Genetics.

Iacoangeli A, Lin T et al.

Cell Rep

We meta-analyze amyotrophic lateral sclerosis (ALS) genome-wide association study (GWAS) data of Eur...

Amyotrophic lateral sclerosis

Replicated

86196

Participants

N/A

Studies

Details PubMed

GWAS 2020-09-23

A multi-ethnic meta-analysis identifies novel genes, including ACSL5, associated with amyotrophic lateral sclerosis.

Nakamura R, Misawa K et al.

Commun Biol

Amyotrophic lateral sclerosis (ALS) is a devastating progressive motor neuron disease that affects p...

Amyotrophic lateral sclerosis

Replicated

90105

Participants

N/A

Studies

Details PubMed

GWAS 2019-11-08

Identification of TYW3/CRYZ and FGD4 as susceptibility genes for amyotrophic lateral sclerosis.

Wei L, Tian Y et al.

Neurol Genet

Objective: A 2-stage genome-wide association was conducted to explore the genetic etiology of amyotr...

Amyotrophic lateral sclerosis

Replicated

10867

Participants

N/A

Studies

Details PubMed

GWAS 2019-04-11

Exome array analysis of rare and low frequency variants in amyotrophic lateral sclerosis.

Dekker AM, Diekstra FP et al.

Sci Rep

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects 1 in ~350 indi...

Amyotrophic lateral sclerosis

7350

Participants

N/A

Studies

Details PubMed

GWAS 2018-03-21

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

Nicolas A, Kenna KP et al.

Neuron

To identify novel genes associated with ALS, we undertook two lines of investigation. We carried out...

Amyotrophic lateral sclerosis

Replicated

103419

Participants

N/A

Studies

Details PubMed

GWAS 2017-09-20

Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis.

Benyamin B, He J et al.

Nat Commun

Cross-ethnic genetic studies can leverage power from differences in disease epidemiology and populat...

Amyotrophic lateral sclerosis (sporadic)

Replicated

41395

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Large-scale exome analyses reveal new rare variant contributions in amyotrophic lateral sclerosis.

Hop PJ

Nat Genet

Amyotrophic lateral sclerosis

2026-03-31

A genome-wide association study identifies the GPM6A locus associated with age at onset in ALS.

Nakamura R

Commun Biol

Amyotrophic lateral sclerosis (age of onset)

2025-12-05

Identifying risk loci for FTD and shared genetic component with ALS: A large-scale multitrait association analysis.

Chen K, Gao T et al.

Neurobiol Aging

Frontotemporal dementia (MTAG)

2023-09-28

Genetic factors affecting survival in Japanese patients with sporadic amyotrophic lateral sclerosis: a genome-wide association study and verification in iPSC-derived motor neurons from patients.

Nakamura R

J Neurol Neurosurg Psychiatry

Survival in sporadic amyotrophic lateral sclerosis

2023-05-04

Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology.

van Rheenen W, van der Spek RAA et al.

Nat Genet

Amyotrophic lateral sclerosis

2021-12-06

Genome-wide association study of frontotemporal dementia identifies a C9ORF72 haplotype with a median of 12-G4C2 repeats that predisposes to pathological repeat expansions.

Reus LM, Jansen IE et al.

Transl Psychiatry

Frontotemporal dementia

2021-09-02

Genome-wide Meta-analysis Finds the ACSL5-ZDHHC6 Locus Is Associated with ALS and Links Weight Loss to the Disease Genetics.

Iacoangeli A, Lin T et al.

Cell Rep

Amyotrophic lateral sclerosis

2020-10-01

A multi-ethnic meta-analysis identifies novel genes, including ACSL5, associated with amyotrophic lateral sclerosis.

Nakamura R, Misawa K et al.

Commun Biol

Amyotrophic lateral sclerosis

2020-09-23

Identification of TYW3/CRYZ and FGD4 as susceptibility genes for amyotrophic lateral sclerosis.

Wei L, Tian Y et al.

Neurol Genet

Amyotrophic lateral sclerosis

2019-11-08

Exome array analysis of rare and low frequency variants in amyotrophic lateral sclerosis.

Dekker AM, Diekstra FP et al.

Sci Rep

Amyotrophic lateral sclerosis

2019-04-11

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

Nicolas A, Kenna KP et al.

Neuron

Amyotrophic lateral sclerosis

2018-03-21

Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis.

Benyamin B, He J et al.

Nat Commun

Amyotrophic lateral sclerosis (sporadic)

2017-09-20