Active: Blood pressure Clear all

GWAS 2025-09-26

Genetic impact of central adiposity on systolic blood pressure in females: interaction and mediation by TG/HDL-C, HbA1c, and uric acid across BMI categories.

Gumilang RA, Bai CH

Int J Obes (Lond)

Genetic predisposition to central adiposity is associated with metabolic dysfunction and obesity-rel...

Waist circumference

49188

Participants

N/A

Studies

Details PubMed

GWAS 2025-06-13

Beyond volume: Unraveling the genetics of human brain geometry.

Primus SA, Hoffstaedter F et al.

Sci Adv

Brain geometry affects brain function. A quantitative encoding of form is provided by the Laplace-Be...

Left accumbens area shape (Laplace-Beltrami spectrum)

Replicated

24823

Participants

N/A

Studies

Details PubMed

GWAS 2025-06-11

A mathematical model that predicts human biological age from physiological traits identifies environmental and genetic factors that influence aging.

Libert S, Chekholko A et al.

Elife

Why people age at different rates is a fundamental, unsolved problem in biology. We created a model ...

Biological age difference (delta-Age)

133184

Participants

N/A

Studies

Details PubMed

GWAS 2025-04-07

Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum.

Lee DSM, Cardone KM et al.

Nat Genet

Heart failure is a complex trait, influenced by environmental and genetic factors, affecting over 30...

Heart failure

2358556

Participants

N/A

Studies

Details PubMed

GWAS 2025-04-04

A large-scale genome-wide study of gene-sleep duration interactions for blood pressure in 811,405 individuals from diverse populations.

Nagarajan P, Winkler TW et al.

Mol Psychiatry

Although both short and long sleep duration are associated with elevated hypertension risk, our unde...

Systolic blood pressure x short total sleep time interaction (main effect)

810633

Participants

N/A

Studies

Details PubMed

GWAS 2025-03-25

Leveraging large-scale biobank EHRs to enhance pharmacogenetics of cardiometabolic disease medications.

Sadler MC, Apostolov A et al.

Nat Commun

Electronic health records (EHRs) coupled with large-scale biobanks offer great promises to unravel t...

Systolic blood pressure response to angiotensin-converting enzyme inhibitors (absolute difference)

Replicated

5034

Participants

N/A

Studies

Details PubMed

GWAS 2025-01-17

Genome-wide and phenome-wide studies provided insights into brain glymphatic system function and its clinical associations.

Ran L, Fang Y et al.

Sci Adv

We applied an MRI technique diffusion tensor imaging along the perivascular space (DTI-ALPS) for ass...

Anterior diffusion tensor imaging along the perivascular space index

31629

Participants

N/A

Studies

Details PubMed

GWAS 2024-12-10

Large-scale brainstem neuroimaging and genetic analyses provide new insights into the neuronal mechanisms of hypertension.

Gurholt TP, Elvsåshagen T et al.

HGG Adv

While brainstem regions are central regulators of blood pressure, the neuronal mechanisms underlying...

Systolic blood pressure

174014

Participants

N/A

Studies

Details PubMed

GWAS 2024-11-21

Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience.

Jurgens SJ, Rämö JT et al.

Nat Genet

Dilated cardiomyopathy (DCM) is a heart muscle disease that represents an important cause of morbidi...

Dilated cardiomyopathy

Replicated

2404278

Participants

N/A

Studies

Details PubMed

GWAS 2024-11-15

Assessing the predictive efficacy of European-based systolic blood pressure polygenic risk scores in diverse Brazilian cohorts.

Teixeira SK, Rossi FPN et al.

Sci Rep

Despite the identification of numerous genetic variants affecting SBP in European populations, their...

Systolic blood pressure

286581

Participants

N/A

Studies

Details PubMed

GWAS 2024-11-06

Phenotypic and genetic characteristics of retinal vascular parameters and their association with diseases.

Ortín Vela S, Beyeler MJ et al.

Nat Commun

Fundus images allow for non-invasive assessment of the retinal vasculature whose features provide im...

Retinal venular temporal angle

57486

Participants

N/A

Studies

Details PubMed

GWAS 2024-09-13

Genome-wide association studies of thyroid-related hormones, dysfunction, and autoimmunity among 85,421 Chinese pregnancies.

Wei Y, Zhen J et al.

Nat Commun

Maintaining normal thyroid function is crucial in pregnancy, yet thyroid dysfunction and the presenc...

Thyroid stimulating hormone levels within normal range in pregnancy

67471

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genetic impact of central adiposity on systolic blood pressure in females: interaction and mediation by TG/HDL-C, HbA1c, and uric acid across BMI categories.

Gumilang RA, Bai CH

Int J Obes (Lond)

Waist circumference

2025-09-26

Beyond volume: Unraveling the genetics of human brain geometry.

Primus SA, Hoffstaedter F et al.

Sci Adv

Left accumbens area shape (Laplace-Beltrami spectrum)

2025-06-13

A mathematical model that predicts human biological age from physiological traits identifies environmental and genetic factors that influence aging.

Libert S, Chekholko A et al.

Elife

Biological age difference (delta-Age)

2025-06-11

Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum.

Lee DSM, Cardone KM et al.

Nat Genet

Heart failure

2025-04-07

A large-scale genome-wide study of gene-sleep duration interactions for blood pressure in 811,405 individuals from diverse populations.

Nagarajan P, Winkler TW et al.

Mol Psychiatry

Systolic blood pressure x short total sleep time interaction (main effect)

2025-04-04

Leveraging large-scale biobank EHRs to enhance pharmacogenetics of cardiometabolic disease medications.

Sadler MC, Apostolov A et al.

Nat Commun

Systolic blood pressure response to angiotensin-converting enzyme inhibitors (absolute difference)

2025-03-25

Genome-wide and phenome-wide studies provided insights into brain glymphatic system function and its clinical associations.

Ran L, Fang Y et al.

Sci Adv

Anterior diffusion tensor imaging along the perivascular space index

2025-01-17

Large-scale brainstem neuroimaging and genetic analyses provide new insights into the neuronal mechanisms of hypertension.

Gurholt TP, Elvsåshagen T et al.

HGG Adv

Systolic blood pressure

2024-12-10

Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience.

Jurgens SJ, Rämö JT et al.

Nat Genet

Dilated cardiomyopathy

2024-11-21

Assessing the predictive efficacy of European-based systolic blood pressure polygenic risk scores in diverse Brazilian cohorts.

Teixeira SK, Rossi FPN et al.

Sci Rep

Systolic blood pressure

2024-11-15

Phenotypic and genetic characteristics of retinal vascular parameters and their association with diseases.

Ortín Vela S, Beyeler MJ et al.

Nat Commun

Retinal venular temporal angle

2024-11-06

Genome-wide association studies of thyroid-related hormones, dysfunction, and autoimmunity among 85,421 Chinese pregnancies.

Wei Y, Zhen J et al.

Nat Commun

Thyroid stimulating hormone levels within normal range in pregnancy

2024-09-13