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GWAS 2024-03-14

A cross-trait study of lung cancer and its related respiratory diseases based on large-scale exome sequencing population.

Jiang Y, Li H et al.

Transl Lung Cancer Res

Genome-wide association studies (GWASs) explain the genetic susceptibility between diseases and comm...

Emphysema

427934

Participants

N/A

Studies

Details PubMed

GWAS 2024-01-02

Pulmonary function and atherosclerosis in the general population: causal associations and clinical implications.

Engström G, Lampa E et al.

Eur J Epidemiol

Reduced lung function is associated with cardiovascular mortality, but the relationships with athero...

Forced expiratory volume in 1 second (FEV1)

255647

Participants

N/A

Studies

Details PubMed

GWAS 2023-05-11

A Large-Scale Exome-Wide Association Study Identifies Novel Germline Mutations in Lung Cancer.

Shen S, Li Z et al.

Am J Respir Crit Care Med

Rationale: Genome-wide association studies have identified common variants of lung cancer. However, ...

Adenocarcinoma

Replicated

664374

Participants

N/A

Studies

Details PubMed

GWAS 2021-08-17

A genome-wide association study of quantitative computed tomographic emphysema in Korean populations.

Sin S, Choi HM et al.

Sci Rep

Emphysema is an important feature of chronic obstructive pulmonary disease (COPD). Genetic factors l...

Emphysema

548

Participants

N/A

Studies

Details PubMed

GWAS 2019-07-19

DSP variants may be associated with longitudinal change in quantitative emphysema.

Kim W, Cho MH et al.

Respir Res

Emphysema, characterized by lung destruction, is a key component of Chronic Obstructive Pulmonary Di...

Emphysema annual change measurement in smokers (adjusted lung density)

5585

Participants

N/A

Studies

Details PubMed

GWAS 2019-01-29

Genome-Wide Association Analysis of Single Breath Diffusing Capacity of Carbon Monoxide (DLCO).

Sakornsakolpat P, McCormack M et al.

Am J Respir Cell Mol Biol

DlCO is a widely used pulmonary function test in clinical practice and a particularly useful measure...

Diffusing capacity of carbon monoxide

6935

Participants

N/A

Studies

Details PubMed

GWAS 2016-09-26

Genome-Wide Association Study of the Genetic Determinants of Emphysema Distribution.

Boueiz A, Lutz SM et al.

Am J Respir Crit Care Med

Rationale: Emphysema has considerable variability in the severity and distribution of parenchymal de...

Emphysema distribution in smoking

11532

Participants

N/A

Studies

Details PubMed

GWAS 2016-08-17

Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD.

Sun W, Kechris K et al.

PLoS Genet

Implementing precision medicine for complex diseases such as chronic obstructive lung disease (COPD)...

Blood protein levels

1340

Participants

N/A

Studies

Details PubMed

GWAS 2015-06-01

A Genome-Wide Association Study of Emphysema and Airway Quantitative Imaging Phenotypes.

Cho MH, Castaldi PJ et al.

Am J Respir Crit Care Med

Rationale: Chronic obstructive pulmonary disease (COPD) is defined by the presence of airflow limita...

Percentage gas trapping

9338

Participants

N/A

Studies

Details PubMed

GWAS 2014-07-09

Genome-wide association identifies regulatory Loci associated with distinct local histogram emphysema patterns.

Castaldi PJ, Cho MH et al.

Am J Respir Crit Care Med

Rationale: Emphysema is a heritable trait that occurs in smokers with and without chronic obstructiv...

Local histogram emphysema pattern

9614

Participants

N/A

Studies

Details PubMed

GWAS 2014-01-02

Genome-wide study of percent emphysema on computed tomography in the general population. The Multi-Ethnic Study of Atherosclerosis Lung/SNP Health Association Resource Study.

Manichaikul A, Hoffman EA et al.

Am J Respir Crit Care Med

Rationale: Pulmonary emphysema overlaps partially with spirometrically defined chronic obstructive p...

Pulmonary emphysema

Replicated

13937

Participants

N/A

Studies

Details PubMed

GWAS 2013-05-16

Imputation of variants from the 1000 Genomes Project modestly improves known associations and can identify low-frequency variant-phenotype associations undetected by HapMap based imputation.

Wood AR, Perry JR et al.

PLoS One

Genome-wide association (GWA) studies have been limited by the reliance on common variants present o...

Blood protein levels

Replicated

1209

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

A cross-trait study of lung cancer and its related respiratory diseases based on large-scale exome sequencing population.

Jiang Y, Li H et al.

Transl Lung Cancer Res

Emphysema

2024-03-14

Pulmonary function and atherosclerosis in the general population: causal associations and clinical implications.

Engström G, Lampa E et al.

Eur J Epidemiol

Forced expiratory volume in 1 second (FEV1)

2024-01-02

A Large-Scale Exome-Wide Association Study Identifies Novel Germline Mutations in Lung Cancer.

Shen S, Li Z et al.

Am J Respir Crit Care Med

Adenocarcinoma

2023-05-11

A genome-wide association study of quantitative computed tomographic emphysema in Korean populations.

Sin S, Choi HM et al.

Sci Rep

Emphysema

2021-08-17

DSP variants may be associated with longitudinal change in quantitative emphysema.

Kim W, Cho MH et al.

Respir Res

Emphysema annual change measurement in smokers (adjusted lung density)

2019-07-19

Genome-Wide Association Analysis of Single Breath Diffusing Capacity of Carbon Monoxide (DLCO).

Sakornsakolpat P, McCormack M et al.

Am J Respir Cell Mol Biol

Diffusing capacity of carbon monoxide

2019-01-29

Genome-Wide Association Study of the Genetic Determinants of Emphysema Distribution.

Boueiz A, Lutz SM et al.

Am J Respir Crit Care Med

Emphysema distribution in smoking

2016-09-26

Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD.

Sun W, Kechris K et al.

PLoS Genet

Blood protein levels

2016-08-17

A Genome-Wide Association Study of Emphysema and Airway Quantitative Imaging Phenotypes.

Cho MH, Castaldi PJ et al.

Am J Respir Crit Care Med

Percentage gas trapping

2015-06-01

Genome-wide association identifies regulatory Loci associated with distinct local histogram emphysema patterns.

Castaldi PJ, Cho MH et al.

Am J Respir Crit Care Med

Local histogram emphysema pattern

2014-07-09

Genome-wide study of percent emphysema on computed tomography in the general population. The Multi-Ethnic Study of Atherosclerosis Lung/SNP Health Association Resource Study.

Manichaikul A, Hoffman EA et al.

Am J Respir Crit Care Med

Pulmonary emphysema

2014-01-02

Imputation of variants from the 1000 Genomes Project modestly improves known associations and can identify low-frequency variant-phenotype associations undetected by HapMap based imputation.

Wood AR, Perry JR et al.

PLoS One

Blood protein levels

2013-05-16