Genome-Wide Association Study of the Genetic Determinants of Emphysema Distribution.
Boueiz A, Lutz SM, Cho MH et al.
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Abstract
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Rationale: Emphysema has considerable variability in the severity and distribution of parenchymal destruction throughout the lungs. Upper lobe-predominant emphysema has emerged as an important predictor of response to lung volume reduction surgery. Yet, aside from alpha-1 antitrypsin deficiency, the genetic determinants of emphysema distribution remain largely unknown.
7,039 European ancestry individuals, 2,955 African American individuals, 1538 individuals
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