Active: Femoral neck bone mineral density Clear all

GWAS 2024-01-12

Femoral Neck Width Genetic Risk Score is A Novel Independent Risk Factor for Hip Fractures.

Tobias JH, Nethander M et al.

J Bone Miner Res

Femoral neck width (FNW) derived from DXA scans may provide a useful adjunct to hip fracture predict...

Femoral neck width

38150

Participants

N/A

Studies

Details PubMed

GWAS 2020-09-24

Three pleiotropic loci associated with bone mineral density and lean body mass.

Zhang YX, Zhang SS et al.

Mol Genet Genomics

Both bone mineral density (BMD) and lean body mass (LBM) are important physiological measures with s...

Bone mineral density or leg lean mass (pleiotropy)

Replicated

512445

Participants

N/A

Studies

Details PubMed

GWAS 2020-04-01

Two novel pleiotropic loci associated with osteoporosis and abdominal obesity.

Liu L, Yang XL et al.

Hum Genet

Aiming to uncover a shared genetic basis of abdominal obesity and osteoporosis, we performed a bivar...

Femoral neck bone mineral density

13035

Participants

N/A

Studies

Details PubMed

GWAS 2019-08-02

Mendelian Randomization Analysis Reveals a Causal Influence of Circulating Sclerostin Levels on Bone Mineral Density and Fractures.

Zheng J, Maerz W et al.

J Bone Miner Res

In bone, sclerostin is mainly osteocyte-derived and plays an important local role in adaptive respon...

Serum sclerostin levels

10584

Participants

N/A

Studies

Details PubMed

GWAS 2018-08-30

Identification of novel variants associated with osteoporosis, type 2 diabetes and potentially pleiotropic loci using pleiotropic cFDR method.

Hu Y, Tan LJ et al.

Bone

Aims: Clinical and epidemiological findings point to an association between type 2 diabetes (T2D) an...

Femoral neck bone mineral density or type 2 diabetes (pleiotropy)

212444

Participants

N/A

Studies

Details PubMed

GWAS 2018-02-27

Joint study of two genome-wide association meta-analyses identified 20p12.1 and 20q13.33 for bone mineral density.

Pei YF, Hu WZ et al.

Bone

In the present study, aiming to identify loci associated with osteoporosis, we conducted a joint ass...

Femoral neck bone mineral density

40491

Participants

N/A

Studies

Details PubMed

GWAS 2018-01-11

Identifying potentially common genes between dyslipidemia and osteoporosis using novel analytical approaches.

Lin X, Peng C et al.

Mol Genet Genomics

Dyslipidemia (DL) is closely related to osteoporosis (OP), while the exact common genetic mechanisms...

Femoral neck bone mineral density or plasma lipids (pleiotropy)

238565

Participants

N/A

Studies

Details PubMed

GWAS 2015-10-01

Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture.

Zheng HF, Forgetta V et al.

Nature

The extent to which low-frequency (minor allele frequency (MAF) between 1-5%) and rare (MAF ≤ 1%) va...

Femoral neck bone mineral density

Replicated

49988

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Femoral Neck Width Genetic Risk Score is A Novel Independent Risk Factor for Hip Fractures.

Tobias JH, Nethander M et al.

J Bone Miner Res

Femoral neck width

2024-01-12

Three pleiotropic loci associated with bone mineral density and lean body mass.

Zhang YX, Zhang SS et al.

Mol Genet Genomics

Bone mineral density or leg lean mass (pleiotropy)

2020-09-24

Two novel pleiotropic loci associated with osteoporosis and abdominal obesity.

Liu L, Yang XL et al.

Hum Genet

Femoral neck bone mineral density

2020-04-01

Mendelian Randomization Analysis Reveals a Causal Influence of Circulating Sclerostin Levels on Bone Mineral Density and Fractures.

Zheng J, Maerz W et al.

J Bone Miner Res

Serum sclerostin levels

2019-08-02

Identification of novel variants associated with osteoporosis, type 2 diabetes and potentially pleiotropic loci using pleiotropic cFDR method.

Hu Y, Tan LJ et al.

Bone

Femoral neck bone mineral density or type 2 diabetes (pleiotropy)

2018-08-30

Joint study of two genome-wide association meta-analyses identified 20p12.1 and 20q13.33 for bone mineral density.

Pei YF, Hu WZ et al.

Bone

Femoral neck bone mineral density

2018-02-27

Identifying potentially common genes between dyslipidemia and osteoporosis using novel analytical approaches.

Lin X, Peng C et al.

Mol Genet Genomics

Femoral neck bone mineral density or plasma lipids (pleiotropy)

2018-01-11

Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture.

Zheng HF, Forgetta V et al.

Nature

Femoral neck bone mineral density

2015-10-01