Active: Knee osteoarthritis Clear all

GWAS 2022-11-14

Genome-wide association meta-analysis of knee and hip osteoarthritis uncovers genetic differences between patients treated with joint replacement and patients without joint replacement.

Henkel C, Styrkársdóttir U et al.

Ann Rheum Dis

Objectives: Osteoarthritis is a common and severe, multifactorial disease with a well-established ge...

Surgical knee osteoarthritis

661143

Participants

N/A

Studies

Details PubMed

GWAS 2022-08-23

Characterization of Genetic Risk of End-Stage Knee Osteoarthritis Treated with Total Knee Arthroplasty: A Genome-Wide Association Study.

Kulm S, Kolin DA et al.

J Bone Joint Surg Am

End-stage knee osteoarthritis (OA) is a highly debilitating disease for which total knee arthroplast...

End-stage knee osteoarthritis

389548

Participants

N/A

Studies

Details PubMed

GWAS 2019-08-28

Genome-wide association study of knee pain identifies associations with GDF5 and COL27A1 in UK Biobank.

Meng W, Adams MJ et al.

Commun Biol

Knee pain is one of the most common musculoskeletal complaints that brings people to medical attenti...

Knee pain

171516

Participants

N/A

Studies

Details PubMed

GWAS 2019-01-21

Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.

Tachmazidou I, Hatzikotoulas K et al.

Nat Genet

Osteoarthritis is the most common musculoskeletal disease and the leading cause of disability global...

Knee osteoarthritis

403124

Participants

N/A

Studies

Details PubMed

GWAS 2018-10-29

Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis.

Styrkarsdottir U, Lund SH et al.

Nat Genet

Osteoarthritis has a highly negative impact on quality of life because of the associated pain and lo...

Knee osteoarthritis

586030

Participants

N/A

Studies

Details PubMed

GWAS 2017-09-15

Genetic Determinants of Radiographic Knee Osteoarthritis in African Americans.

Liu Y, Yau MS et al.

J Rheumatol

Objective: The etiology of knee osteoarthritis (OA), the most common form of arthritis, is complex a...

Knee osteoarthritis

1217

Participants

N/A

Studies

Details PubMed

GWAS 2016-10-01

Genome-Wide Association Study of Radiographic Knee Osteoarthritis in North American Caucasians.

Yau MS, Yerges-Armstrong LM et al.

Arthritis Rheumatol

Objective: A major barrier to genetic studies of osteoarthritis (OA) is the need to obtain large num...

Knee osteoarthritis

Replicated

7066

Participants

N/A

Studies

Details PubMed

GWAS 2010-03-18

New sequence variants in HLA class II/III region associated with susceptibility to knee osteoarthritis identified by genome-wide association study.

Nakajima M, Takahashi A et al.

PLoS One

Osteoarthritis (OA) is a common disease that has a definite genetic component. Only a few OA suscept...

Knee osteoarthritis

Replicated

6693

Participants

N/A

Studies

Details PubMed

GWAS 2008-05-08

Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis.

Valdes AM, Loughlin J et al.

Am J Hum Genet

Osteoarthritis (OA), the most prevalent form of arthritis in the elderly, is characterized by the de...

Knee osteoarthritis

Replicated

4191

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genome-wide association meta-analysis of knee and hip osteoarthritis uncovers genetic differences between patients treated with joint replacement and patients without joint replacement.

Henkel C, Styrkársdóttir U et al.

Ann Rheum Dis

Surgical knee osteoarthritis

2022-11-14

Characterization of Genetic Risk of End-Stage Knee Osteoarthritis Treated with Total Knee Arthroplasty: A Genome-Wide Association Study.

Kulm S, Kolin DA et al.

J Bone Joint Surg Am

End-stage knee osteoarthritis

2022-08-23

Genome-wide association study of knee pain identifies associations with GDF5 and COL27A1 in UK Biobank.

Meng W, Adams MJ et al.

Commun Biol

Knee pain

2019-08-28

Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.

Tachmazidou I, Hatzikotoulas K et al.

Nat Genet

Knee osteoarthritis

2019-01-21

Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis.

Styrkarsdottir U, Lund SH et al.

Nat Genet

Knee osteoarthritis

2018-10-29

Genetic Determinants of Radiographic Knee Osteoarthritis in African Americans.

Liu Y, Yau MS et al.

J Rheumatol

Knee osteoarthritis

2017-09-15

Genome-Wide Association Study of Radiographic Knee Osteoarthritis in North American Caucasians.

Yau MS, Yerges-Armstrong LM et al.

Arthritis Rheumatol

Knee osteoarthritis

2016-10-01

New sequence variants in HLA class II/III region associated with susceptibility to knee osteoarthritis identified by genome-wide association study.

Nakajima M, Takahashi A et al.

PLoS One

Knee osteoarthritis

2010-03-18

Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis.

Valdes AM, Loughlin J et al.

Am J Hum Genet

Knee osteoarthritis

2008-05-08