Genome-Wide Association Study of Radiographic Knee Osteoarthritis in North American Caucasians.
Yau MS, Yerges-Armstrong LM, Liu Y et al.
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Objective: A major barrier to genetic studies of osteoarthritis (OA) is the need to obtain large numbers of individuals with standardized radiographic evaluations for OA. To address this gap, we performed a genome-wide association study (GWAS) of radiographically defined tibiofemoral knee OA in 3,898 cases and 3,168 controls from 4 well-characterized North American cohorts, and we performed replication analysis of previously reported OA loci.
2,672 European ancestry cases, 1,776 European ancestry controls
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