Active: Osteoarthritis Clear all

GWAS 2025-04-11

The genetic architecture of and evolutionary constraints on the human pelvic form.

Xu L, Kun E et al.

Science

Human pelvic evolution following the human-chimpanzee divergence is thought to result in an obstetri...

Acetabular diameter

31115

Participants

N/A

Studies

Details PubMed

GWAS 2025-04-09

Translational genomics of osteoarthritis in 1,962,069 individuals.

Hatzikotoulas K, Southam L et al.

Nature

Osteoarthritis is the third most rapidly growing health condition associated with disability, after ...

Osteoarthritis

1962069

Participants

N/A

Studies

Details PubMed

GWAS 2024-11-22

The genetic architecture of hip shape and its role in the development of hip osteoarthritis and fracture.

Faber BG, Frysz M et al.

Hum Mol Genet

Objectives: Hip shape is thought to be an important causal risk factor for hip osteoarthritis and fr...

Hip shape mode 1

43485

Participants

N/A

Studies

Details PubMed

GWAS 2023-08-22

The identification of distinct protective and susceptibility mechanisms for hip osteoarthritis: findings from a genome-wide association study meta-analysis of minimum joint space width and Mendelian randomisation cluster analyses.

Faber BG, Frysz M et al.

EBioMedicine

Hip minimum joint space width (mJSW) provides a proxy for cartilage thickness. This study aimed to c...

Hip minimal joint space width

50745

Participants

N/A

Studies

Details PubMed

GWAS 2023-07-21

The genetic architecture and evolution of the human skeletal form.

Kun E, Javan EM et al.

Science

The human skeletal form underlies bipedalism, but the genetic basis of skeletal proportions (SPs) is...

Forearm length to body height ratio

31221

Participants

N/A

Studies

Details PubMed

GWAS 2023-06-16

A shared genetic contribution to osteoarthritis and COVID-19 outcomes: a large-scale genome-wide cross-trait analysis.

Huang YX, Tian T et al.

Front Immunol

Patients with osteoarthritis (OA) are exposed to an increased risk of adverse outcomes of COVID-19, ...

Critical COVID-19 or osteoarthritis (MTAG)

1703212

Participants

N/A

Studies

Details PubMed

GWAS 2023-05-27

Lifetime risk and genetic predisposition to post-traumatic OA of the knee in the UK Biobank.

Hollis B, Chatzigeorgiou C et al.

Osteoarthritis Cartilage

Objective: Acute knee injury is associated with post-traumatic OA (PTOA). Very little is known about...

Post-traumatic osteoarthritis of knee (time to event)

3074

Participants

N/A

Studies

Details PubMed

GWAS 2023-03-17

Meta-analysis of erosive hand osteoarthritis identifies four common variants that associate with relatively large effect.

Styrkarsdottir U, Stefansdottir L et al.

Ann Rheum Dis

Objectives: Erosive hand osteoarthritis (EHOA) is a severe subset of hand osteoarthritis (OA). It is...

Erosive hand osteoarthritis

552164

Participants

N/A

Studies

Details PubMed

GWAS 2023-03-13

The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions.

Rahmioglu N, Mortlock S et al.

Nat Genet

Endometriosis is a common condition associated with debilitating pelvic pain and infertility. A geno...

Endometriosis

474160

Participants

N/A

Studies

Details PubMed

GWAS 2023-03-06

A sex- and site-specific relationship between body mass index and osteoarthritis: evidence from observational and genetic analyses.

Zhang L, Zhang W et al.

Osteoarthritis Cartilage

Objective: We primarily aimed to investigate whether there are phenotypic and genetic links underlyi...

Body mass index or osteoarthritis (pleiotropy)

1633524

Participants

N/A

Studies

Details PubMed

GWAS 2023-03-06

Genome-Wide Association Study and Transcriptome of Japanese Patients with Developmental Dysplasia of the Hip Demonstrates an Association with the Ferroptosis Signaling Pathway.

Mori Y, Ueno K et al.

Int J Mol Sci

This study examined the association between developmental dysplasia of the hip (DDH) and disease-ass...

Developmental dysplasia of the hip

Replicated

79935

Participants

N/A

Studies

Details PubMed

GWAS 2023-02-03

A Functional Polymorphism Downstream of Vitamin A Regulator Gene <i>CYP26B1</i> Is Associated with Hand Osteoarthritis.

Khosasih V, Liu KM et al.

Int J Mol Sci

While genetic analyses have revealed ~100 risk loci associated with osteoarthritis (OA), only eight ...

Hand Osteoarthritis

1136

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

The genetic architecture of and evolutionary constraints on the human pelvic form.

Xu L, Kun E et al.

Science

Acetabular diameter

2025-04-11

Translational genomics of osteoarthritis in 1,962,069 individuals.

Hatzikotoulas K, Southam L et al.

Nature

Osteoarthritis

2025-04-09

The genetic architecture of hip shape and its role in the development of hip osteoarthritis and fracture.

Faber BG, Frysz M et al.

Hum Mol Genet

Hip shape mode 1

2024-11-22

The identification of distinct protective and susceptibility mechanisms for hip osteoarthritis: findings from a genome-wide association study meta-analysis of minimum joint space width and Mendelian randomisation cluster analyses.

Faber BG, Frysz M et al.

EBioMedicine

Hip minimal joint space width

2023-08-22

The genetic architecture and evolution of the human skeletal form.

Kun E, Javan EM et al.

Science

Forearm length to body height ratio

2023-07-21

A shared genetic contribution to osteoarthritis and COVID-19 outcomes: a large-scale genome-wide cross-trait analysis.

Huang YX, Tian T et al.

Front Immunol

Critical COVID-19 or osteoarthritis (MTAG)

2023-06-16

Lifetime risk and genetic predisposition to post-traumatic OA of the knee in the UK Biobank.

Hollis B, Chatzigeorgiou C et al.

Osteoarthritis Cartilage

Post-traumatic osteoarthritis of knee (time to event)

2023-05-27

Meta-analysis of erosive hand osteoarthritis identifies four common variants that associate with relatively large effect.

Styrkarsdottir U, Stefansdottir L et al.

Ann Rheum Dis

Erosive hand osteoarthritis

2023-03-17

The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions.

Rahmioglu N, Mortlock S et al.

Nat Genet

Endometriosis

2023-03-13

A sex- and site-specific relationship between body mass index and osteoarthritis: evidence from observational and genetic analyses.

Zhang L, Zhang W et al.

Osteoarthritis Cartilage

Body mass index or osteoarthritis (pleiotropy)

2023-03-06

Genome-Wide Association Study and Transcriptome of Japanese Patients with Developmental Dysplasia of the Hip Demonstrates an Association with the Ferroptosis Signaling Pathway.

Mori Y, Ueno K et al.

Int J Mol Sci

Developmental dysplasia of the hip

2023-03-06

A Functional Polymorphism Downstream of Vitamin A Regulator Gene <i>CYP26B1</i> Is Associated with Hand Osteoarthritis.

Khosasih V, Liu KM et al.

Int J Mol Sci

Hand Osteoarthritis

2023-02-03