Meta-analysis of erosive hand osteoarthritis identifies four common variants that associate with relatively large effect.
Styrkarsdottir U, Stefansdottir L, Thorleifsson G et al.
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Abstract
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Objectives: Erosive hand osteoarthritis (EHOA) is a severe subset of hand osteoarthritis (OA). It is unclear if EHOA is genetically different from other forms of OA. Sequence variants at ten loci have been associated with hand OA but none with EHOA.
1,484 European ancestry cases, 550,680 European ancestry controls
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