Active: Primary biliary cholangitis Clear all

GWAS 2024-04-23

A genome-wide association study identified PTPN2 as a population-specific susceptibility gene locus for primary biliary cholangitis.

Hitomi Y

Hepatology

Primary biliary cholangitis

4880

Participants

N/A

Studies

Details PubMed

GWAS 2021-05-22

An international genome-wide meta-analysis of primary biliary cholangitis: novel risk loci and candidate drugs.

Cordell HJ, Fryett JJ et al.

J Hepatol

Backgrounds & aims: Primary biliary cholangitis (PBC) is a chronic liver disease in which autoim...

Primary biliary cholangitis

24510

Participants

N/A

Studies

Details PubMed

GWAS 2019-03-10

Genome Wide Association Studies of Specific Antinuclear Autoantibody Sub-phenotypes in Primary Biliary Cholangitis.

Wang C, Zheng X et al.

Hepatology

Anti-nuclear antibodies to speckled 100 kDa (sp100) and glycoprotein 210 (gp210) are specific serolo...

Anti-sp100 seropositivity in primary biliary cholangitis

Replicated

2174

Participants

N/A

Studies

Details PubMed

GWAS 2019-01-14

POGLUT1, the putative effector gene driven by rs2293370 in primary biliary cholangitis susceptibility locus chromosome 3q13.33.

Hitomi Y, Ueno K et al.

Sci Rep

Primary biliary cholangitis (PBC) is a chronic and cholestatic autoimmune liver disease caused by th...

Primary biliary cholangitis

3574

Participants

N/A

Studies

Details PubMed

GWAS 2017-04-20

A genome-wide association study identifies six novel risk loci for primary biliary cholangitis.

Qiu F, Tang R et al.

Nat Commun

Primary biliary cholangitis (PBC) is an autoimmune liver disease with a strong hereditary component....

Primary biliary cholangitis

Replicated

8192

Participants

N/A

Studies

Details PubMed

GWAS 2017-01-06

A novel approach to genome-wide association analysis identifies genetic associations with primary biliary cholangitis and primary sclerosing cholangitis in Polish patients.

Paziewska A, Habior A et al.

BMC Med Genomics

Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are forms of hepatic auto...

Primary biliary cholangitis

1377

Participants

N/A

Studies

Details PubMed

GWAS 2017-01-05

Genome-wide association studies identify PRKCB as a novel genetic susceptibility locus for primary biliary cholangitis in the Japanese population.

Kawashima M, Hitomi Y et al.

Hum Mol Genet

A previous genome-wide association study (GWAS) performed in 963 Japanese individuals (487 primary b...

Primary biliary cholangitis

Replicated

9910

Participants

N/A

Studies

Details PubMed

GWAS 2015-09-22

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways.

Cordell HJ, Han Y et al.

Nat Commun

Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomo...

Primary biliary cholangitis

Replicated

21216

Participants

N/A

Studies

Details PubMed

GWAS 2012-09-18

Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population.

Nakamura M, Nishida N et al.

Am J Hum Genet

For the identification of susceptibility loci for primary biliary cirrhosis (PBC), a genome-wide ass...

Primary biliary cholangitis

Replicated

2365

Participants

N/A

Studies

Details PubMed

GWAS 2011-03-13

Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.

Mells GF, Floyd JA et al.

Nat Genet

In addition to the HLA locus, six genetic risk factors for primary biliary cirrhosis (PBC) have been...

Primary biliary cholangitis

Replicated

10137

Participants

N/A

Studies

Details PubMed

GWAS 2010-07-18

Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis.

Liu X, Invernizzi P et al.

Nat Genet

A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Ital...

Primary biliary cholangitis

Replicated

5585

Participants

N/A

Studies

Details PubMed

GWAS 2009-05-20

Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants.

Hirschfield GM, Liu X et al.

N Engl J Med

Primary biliary cirrhosis is a chronic granulomatous cholangitis, characteristically associated with...

Primary biliary cholangitis

Replicated

3744

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

A genome-wide association study identified PTPN2 as a population-specific susceptibility gene locus for primary biliary cholangitis.

Hitomi Y

Hepatology

Primary biliary cholangitis

2024-04-23

An international genome-wide meta-analysis of primary biliary cholangitis: novel risk loci and candidate drugs.

Cordell HJ, Fryett JJ et al.

J Hepatol

Primary biliary cholangitis

2021-05-22

Genome Wide Association Studies of Specific Antinuclear Autoantibody Sub-phenotypes in Primary Biliary Cholangitis.

Wang C, Zheng X et al.

Hepatology

Anti-sp100 seropositivity in primary biliary cholangitis

2019-03-10

POGLUT1, the putative effector gene driven by rs2293370 in primary biliary cholangitis susceptibility locus chromosome 3q13.33.

Hitomi Y, Ueno K et al.

Sci Rep

Primary biliary cholangitis

2019-01-14

A genome-wide association study identifies six novel risk loci for primary biliary cholangitis.

Qiu F, Tang R et al.

Nat Commun

Primary biliary cholangitis

2017-04-20

A novel approach to genome-wide association analysis identifies genetic associations with primary biliary cholangitis and primary sclerosing cholangitis in Polish patients.

Paziewska A, Habior A et al.

BMC Med Genomics

Primary biliary cholangitis

2017-01-06

Genome-wide association studies identify PRKCB as a novel genetic susceptibility locus for primary biliary cholangitis in the Japanese population.

Kawashima M, Hitomi Y et al.

Hum Mol Genet

Primary biliary cholangitis

2017-01-05

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways.

Cordell HJ, Han Y et al.

Nat Commun

Primary biliary cholangitis

2015-09-22

Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population.

Nakamura M, Nishida N et al.

Am J Hum Genet

Primary biliary cholangitis

2012-09-18

Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.

Mells GF, Floyd JA et al.

Nat Genet

Primary biliary cholangitis

2011-03-13

Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis.

Liu X, Invernizzi P et al.

Nat Genet

Primary biliary cholangitis

2010-07-18

Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants.

Hirschfield GM, Liu X et al.

N Engl J Med

Primary biliary cholangitis

2009-05-20