Active: Venous thromboembolism Clear all

GWAS 2024-05-27

Genetic assessment of efficacy and safety profiles of coagulation cascade proteins identifies Factors II and XI as actionable anticoagulant targets.

Gagnon E, Girard A et al.

Eur Heart J Open

Aims: Anticoagulants are routinely used by millions of patients worldwide to prevent blood clots. Ye...

Venous thromboembolism

891375

Participants

N/A

Studies

Details PubMed

GWAS 2024-04-01

Genetic associations of protein-coding variants in venous thromboembolism.

He XY, Wu BS et al.

Nat Commun

Previous genetic studies of venous thromboembolism (VTE) have been largely limited to common variant...

Venous thromboembolism

349038

Participants

N/A

Studies

Details PubMed

GWAS 2023-11-01

A signature of platelet reactivity in CBC scattergrams reveals genetic predictors of thrombotic disease risk.

Verdier H, Thomas P et al.

Blood

Genetic studies of platelet reactivity (PR) phenotypes may identify novel antiplatelet drug targets....

Predicted platelet reactivity

29806

Participants

N/A

Studies

Details PubMed

GWAS 2023-06-07

Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism.

Iglesias MJ, Sanchez-Rivera L et al.

Nat Commun

Venous thromboembolism (VTE) is a common, multi-causal disease with potentially serious short- and l...

CFHR5 plasma levels

50412

Participants

N/A

Studies

Details PubMed

GWAS 2022-05-12

Whole exome sequencing of 14 389 individuals from the ESP and CHARGE consortia identifies novel rare variation associated with hemostatic factors.

Pankratz N, Wei P et al.

Hum Mol Genet

Plasma levels of fibrinogen, coagulation factors VII and VIII and von Willebrand factor (vWF) are fo...

Fibrinogen levels

13638

Participants

N/A

Studies

Details PubMed

GWAS 2022-01-19

Whole exome sequencing identifies genetic variants in Chinese Han pregnant women with venous thromboembolism.

Shen Y, Zhang Y et al.

Thromb Res

Objectives: Venous thromboembolism (VTE) is a common health problem, causing considerable morbidity ...

Venous thromboembolism in pregnancy

Participants

N/A

Studies

Details PubMed

GWAS 2021-10-20

Genetic Profile of Endotoxemia Reveals an Association With Thromboembolism and Stroke.

Leskelä J, Toppila I et al.

J Am Heart Assoc

Background Translocation of lipopolysaccharide from gram-negative bacteria into the systemic circula...

Serum lipopolysaccharide activity

11296

Participants

N/A

Studies

Details PubMed

GWAS 2021-10-13

An assessment of the effect of the genotype on postoperative venous thromboembolism risk in 140,831 surgical patients.

A Christensen M, Bonde A et al.

Ann Med Surg (Lond)

Postoperative Venous Thromboembolism Events (VTE) constitute a major source of morbidity and mortali...

Postoperative venous thromboembolism

140831

Participants

N/A

Studies

Details PubMed

GWAS 2021-09-17

Kallikrein augments the anticoagulant function of the protein C system in thrombin generation.

Wan J, Vadaq N et al.

J Thromb Haemost

Genetics play a significant role in coagulation phenotype and venous thromboembolism risk. Resistanc...

Thrombin generation parameter (lagtime)

327

Participants

N/A

Studies

Details PubMed

GWAS 2021-08-02

Elevated plasma concentration of complement factor C5 is associated with risk of future venous thromboembolism.

Skjeflo EW, Brækkan SK et al.

Blood

The role of complement in the pathogenesis of venous thromboembolism (VTE) is unclear. We wanted to ...

Complement C5 levels

709

Participants

N/A

Studies

Details PubMed

GWAS 2021-07-07

An artificial neural network approach integrating plasma proteomics and genetic data identifies PLXNA4 as a new susceptibility locus for pulmonary embolism.

Razzaq M, Iglesias MJ et al.

Sci Rep

Venous thromboembolism is the third common cardiovascular disease and is composed of two entities, d...

Venous thrombosis or pulmonary embolism

Replicated

2455

Participants

N/A

Studies

Details PubMed

GWAS 2021-02-16

Single- and Multimarker Genome-Wide Scans Evidence Novel Genetic Risk Modifiers for Venous Thromboembolism.

Herrera-Rivero M, Stoll M et al.

Thromb Haemost

Previous genome-wide association studies (GWASs) have established several susceptibility genes for v...

Venous thromboembolism

1863

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genetic assessment of efficacy and safety profiles of coagulation cascade proteins identifies Factors II and XI as actionable anticoagulant targets.

Gagnon E, Girard A et al.

Eur Heart J Open

Venous thromboembolism

2024-05-27

Genetic associations of protein-coding variants in venous thromboembolism.

He XY, Wu BS et al.

Nat Commun

Venous thromboembolism

2024-04-01

A signature of platelet reactivity in CBC scattergrams reveals genetic predictors of thrombotic disease risk.

Verdier H, Thomas P et al.

Blood

Predicted platelet reactivity

2023-11-01

Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism.

Iglesias MJ, Sanchez-Rivera L et al.

Nat Commun

CFHR5 plasma levels

2023-06-07

Whole exome sequencing of 14 389 individuals from the ESP and CHARGE consortia identifies novel rare variation associated with hemostatic factors.

Pankratz N, Wei P et al.

Hum Mol Genet

Fibrinogen levels

2022-05-12

Whole exome sequencing identifies genetic variants in Chinese Han pregnant women with venous thromboembolism.

Shen Y, Zhang Y et al.

Thromb Res

Venous thromboembolism in pregnancy

2022-01-19

Genetic Profile of Endotoxemia Reveals an Association With Thromboembolism and Stroke.

Leskelä J, Toppila I et al.

J Am Heart Assoc

Serum lipopolysaccharide activity

2021-10-20

An assessment of the effect of the genotype on postoperative venous thromboembolism risk in 140,831 surgical patients.

A Christensen M, Bonde A et al.

Ann Med Surg (Lond)

Postoperative venous thromboembolism

2021-10-13

Kallikrein augments the anticoagulant function of the protein C system in thrombin generation.

Wan J, Vadaq N et al.

J Thromb Haemost

Thrombin generation parameter (lagtime)

2021-09-17

Elevated plasma concentration of complement factor C5 is associated with risk of future venous thromboembolism.

Skjeflo EW, Brækkan SK et al.

Blood

Complement C5 levels

2021-08-02

An artificial neural network approach integrating plasma proteomics and genetic data identifies PLXNA4 as a new susceptibility locus for pulmonary embolism.

Razzaq M, Iglesias MJ et al.

Sci Rep

Venous thrombosis or pulmonary embolism

2021-07-07

Single- and Multimarker Genome-Wide Scans Evidence Novel Genetic Risk Modifiers for Venous Thromboembolism.

Herrera-Rivero M, Stoll M et al.

Thromb Haemost

Venous thromboembolism

2021-02-16