Kallikrein augments the anticoagulant function of the protein C system in thrombin generation.
Wan J, Vadaq N, Konings J et al.
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Abstract
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Genetics play a significant role in coagulation phenotype and venous thromboembolism risk. Resistance to the anticoagulant activated protein C (APC) is an established risk for thrombosis. Herein, we explored the genetic determinants of thrombin generation (TG) and thrombomodulin (TM)-modulated TG using plasma from the Human Functional Genomics Project.
327 European ancestry individuals
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