Active: Arthritis Rheumatol Clear all

GWAS 2023-08-10

Genome-wide association study identifies the first germline genetic variant associated with Erdheim Chester disease.

Martínez-López J, Márquez A et al.

Arthritis Rheumatol

Objective: Erdheim-Chester disease (ECD) is rare histiocytosis with a wide range of clinical manifes...

Erdheim-Chester disease

7726

Participants

N/A

Studies

Details PubMed

GWAS 2023-04-25

Lowering of circulating sclerostin may increase risk of atherosclerosis and its risk factors: evidence from a genome-wide association meta-analysis followed by Mendelian randomization.

Zheng J, Wheeler E et al.

Arthritis Rheumatol

Objective: In this study, we aimed to establish the causal effects of lowering sclerostin, target of...

Serum sclerostin levels

33961

Participants

N/A

Studies

Details PubMed

GWAS 2023-01-20

A GWAS meta-analysis of alpha angle suggests cam-type morphology may be a specific feature of hip osteoarthritis in older adults.

Faber BG, Frysz M et al.

Arthritis Rheumatol

Objective: To examine the genetic architecture of cam morphology using alpha angle (AA) as a proxy m...

Alpha angle

44214

Participants

N/A

Studies

Details PubMed

GWAS 2022-12-29

Genome-wide imputation identifies novel associations and localises signals in idiopathic inflammatory myopathies.

Rothwell S, Amos CI et al.

Arthritis Rheumatol

Objective: The idiopathic inflammatory myopathies (IIMs) are heterogeneous diseases thought to be in...

Idiopathic inflammatory myopathy

12825

Participants

N/A

Studies

Details PubMed

GWAS 2022-12-18

HLA-DPB1 is associated with ANCA-associated vasculitis in children.

Gibson KM, Drögemöller BI et al.

Arthritis Rheumatol

Objective: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare, life-th...

Antineutrophil cytoplasmic antibody-associated vasculitis

378

Participants

N/A

Studies

Details PubMed

GWAS 2022-10-25

Association of Gout Polygenic Risk Score with Age at Disease Onset and Tophaceous Disease in European and Polynesian Men with Gout.

Sumpter NA, Takei R et al.

Arthritis Rheumatol

Objective: To determine whether a gout polygenic risk score (PRS) is associated with age at gout ons...

Gout

332370

Participants

N/A

Studies

Details PubMed

GWAS 2022-05-04

Comparative genetic analysis of psoriatic arthritis and psoriasis for the discovery of genetic risk factors and risk prediction modelling.

Soomro M, Stadler M et al.

Arthritis Rheumatol

Objectives: Psoriatic arthritis (PsA) has a strong genetic component, and the identification of gene...

Psoriatic arthritis

26351

Participants

N/A

Studies

Details PubMed

GWAS 2022-03-29

Identification of Novel Loci Shared by Juvenile Idiopathic Arthritis Subtypes through Integrative Genetic Analysis.

Li J, Li YR et al.

Arthritis Rheumatol

Objective: Juvenile idiopathic arthritis (JIA) is the most common chronic immune-mediated joint dise...

Arthritis (juvenile idiopathic)

10495

Participants

N/A

Studies

Details PubMed

GWAS 2021-11-15

Multi-ancestral GWAS identifies shared and Asian-specific loci for SLE and links type III interferon signaling and lysosomal function to the disease.

Wang YF, Wei W et al.

Arthritis Rheumatol

Objective: Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease with differences ...

Systemic lupus erythematosus

17989

Participants

N/A

Studies

Details PubMed

GWAS 2021-01-17

Contribution of a European-Prevalent Variant near CD83 and an East Asian-Prevalent Variant near IL17RB to Herpes Zoster Risk in Tofacitinib Treatment: Results of Genome-Wide Association Study Meta-Analyses.

Bing N, Zhou H et al.

Arthritis Rheumatol

Objective: Tofacitinib is an oral JAK inhibitor for the treatment of rheumatoid arthritis (RA), psor...

Response to tofacitinib treatment in rheumatoid arthritis (herpes zoster)(time to event)

2903

Participants

N/A

Studies

Details PubMed

GWAS 2021-01-04

Genetic association of a gain of function interferon gamma receptor 1 (IFNGR1) polymorphism and the intergenic region LNCAROD/DKK1 with Behçet's disease.

Ortiz Fernández L, Coit P et al.

Arthritis Rheumatol

Objective: Behçet's disease is a complex systemic inflammatory vasculitis of incompletely understood...

Behcet's disease

8982

Participants

N/A

Studies

Details PubMed

GWAS 2018-09-24

A genome-wide association study identifies a 3'UTR genetic variant of RARB associated with carotid intima-media thickness in rheumatoid arthritis.

López-Mejías R, Carmona FD et al.

Arthritis Rheumatol

Objective: To investigate the genetic background influencing the development of cardiovascular (CV) ...

Carotid intima media thickness in rheumatoid arthritis

1355

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genome-wide association study identifies the first germline genetic variant associated with Erdheim Chester disease.

Martínez-López J, Márquez A et al.

Arthritis Rheumatol

Erdheim-Chester disease

2023-08-10

Lowering of circulating sclerostin may increase risk of atherosclerosis and its risk factors: evidence from a genome-wide association meta-analysis followed by Mendelian randomization.

Zheng J, Wheeler E et al.

Arthritis Rheumatol

Serum sclerostin levels

2023-04-25

A GWAS meta-analysis of alpha angle suggests cam-type morphology may be a specific feature of hip osteoarthritis in older adults.

Faber BG, Frysz M et al.

Arthritis Rheumatol

Alpha angle

2023-01-20

Genome-wide imputation identifies novel associations and localises signals in idiopathic inflammatory myopathies.

Rothwell S, Amos CI et al.

Arthritis Rheumatol

Idiopathic inflammatory myopathy

2022-12-29

HLA-DPB1 is associated with ANCA-associated vasculitis in children.

Gibson KM, Drögemöller BI et al.

Arthritis Rheumatol

Antineutrophil cytoplasmic antibody-associated vasculitis

2022-12-18

Association of Gout Polygenic Risk Score with Age at Disease Onset and Tophaceous Disease in European and Polynesian Men with Gout.

Sumpter NA, Takei R et al.

Arthritis Rheumatol

Gout

2022-10-25

Comparative genetic analysis of psoriatic arthritis and psoriasis for the discovery of genetic risk factors and risk prediction modelling.

Soomro M, Stadler M et al.

Arthritis Rheumatol

Psoriatic arthritis

2022-05-04

Identification of Novel Loci Shared by Juvenile Idiopathic Arthritis Subtypes through Integrative Genetic Analysis.

Li J, Li YR et al.

Arthritis Rheumatol

Arthritis (juvenile idiopathic)

2022-03-29

Multi-ancestral GWAS identifies shared and Asian-specific loci for SLE and links type III interferon signaling and lysosomal function to the disease.

Wang YF, Wei W et al.

Arthritis Rheumatol

Systemic lupus erythematosus

2021-11-15

Contribution of a European-Prevalent Variant near CD83 and an East Asian-Prevalent Variant near IL17RB to Herpes Zoster Risk in Tofacitinib Treatment: Results of Genome-Wide Association Study Meta-Analyses.

Bing N, Zhou H et al.

Arthritis Rheumatol

Response to tofacitinib treatment in rheumatoid arthritis (herpes zoster)(time to event)

2021-01-17

Genetic association of a gain of function interferon gamma receptor 1 (IFNGR1) polymorphism and the intergenic region LNCAROD/DKK1 with Behçet's disease.

Ortiz Fernández L, Coit P et al.

Arthritis Rheumatol

Behcet's disease

2021-01-04

A genome-wide association study identifies a 3'UTR genetic variant of RARB associated with carotid intima-media thickness in rheumatoid arthritis.

López-Mejías R, Carmona FD et al.

Arthritis Rheumatol

Carotid intima media thickness in rheumatoid arthritis

2018-09-24