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Genetic association of a gain of function interferon gamma receptor 1 (IFNGR1) polymorphism and the intergenic region LNCAROD/DKK1 with Behçet's disease.

Ortiz Fernández L, Coit P, Yilmaz V et al.

33393726 PubMed ID
GWAS Study Type
8982 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

OF
Ortiz Fernández L
CP
Coit P
YV
Yilmaz V
YS
Yentür SP
AF
Alibaz-Oner F
AK
Aksu K
EE
Erken E
DN
Düzgün N
KG
Keser G
CA
Cefle A
YA
Yazici A
EA
Ergen A
AE
Alpsoy E
SC
Salvarani C
CB
Casali B
KB
Kısacık B
KI
Kötter I
HJ
Henes J
ÇM
Çınar M
SA
Schaefer A
NR
Nohutcu RM
ZA
Zhernakova A
WC
Wijmenga C
TF
Takeuchi F
HS
Harihara S
KT
Kaburaki T
MM
Messedi M
SY
Song YW
KT
Kaşifoğlu T
CF
Carmona FD
GJ
Guthridge JM
JJ
James JA
MJ
Martin J
GE
González Escribano MF
SG
Saruhan-Direskeneli G
DH
Direskeneli H
SA
Sawalha AH
Chapter II

Abstract

Summary of the research findings

Objective: Behçet's disease is a complex systemic inflammatory vasculitis of incompletely understood etiology. This study was undertaken to investigate genetic associations with Behçet's disease in a diverse multiethnic population.

2,344 Turkish ancestry cases, 1,920 Turkish ancestry controls, 437 European ancestry cases, 3,325 European ancestry controls, 312 East Asian ancestry cases, 398 East Asian ancestry controls, 104 Tunisian ancestry cases, 142 Tunisian ancestry controls

Chapter III

Study Statistics

Key metrics and study information

8982
Total Participants
GWAS
Study Type
No
Replicated
European, Other, Greater Middle Eastern (Middle Eastern, North African or Persian), East Asian
Ancestry
Chapter IV

AI-Generated Summary

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