Multi-ancestral GWAS identifies shared and Asian-specific loci for SLE and links type III interferon signaling and lysosomal function to the disease.
Wang YF, Wei W, Tangtanatakul P et al.
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Objective: Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease with differences in prevalence and severity among ancestral groups. This study was undertaken to identify novel genetic components, either shared by or distinct between Asian and European populations.
4,734 Chinese ancestry cases, 9,425 Chinese ancestry controls, 835 Thai ancestry cases, 2,995 Thai ancestry controls
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