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GWAS 2025-06-11

A mathematical model that predicts human biological age from physiological traits identifies environmental and genetic factors that influence aging.

Libert S, Chekholko A et al.

Elife

Why people age at different rates is a fundamental, unsolved problem in biology. We created a model ...

Biological age difference (delta-Age)

133184

Participants

N/A

Studies

Details PubMed

GWAS 2024-10-03

Novel risk loci for COVID-19 hospitalization among admixed American populations.

Diz-de Almeida S, Cruz R et al.

Elife

The genetic basis of severe COVID-19 has been thoroughly studied, and many genetic risk factors shar...

COVID-19 (hospitalized covid vs population)

73275

Participants

N/A

Studies

Details PubMed

GWAS 2024-01-26

Association of genetic variation in COL11A1 with adolescent idiopathic scoliosis.

Yu H, Khanshour AM et al.

Elife

Adolescent idiopathic scoliosis (AIS) is a common and progressive spinal deformity in children that ...

Adolescent idiopathic scoliosis

Replicated

103757

Participants

N/A

Studies

Details PubMed

GWAS 2024-01-15

Multi-ancestry meta-analysis of host genetic susceptibility to tuberculosis identifies shared genetic architecture.

Schurz H, Naranbhai V et al.

Elife

The heritability of susceptibility to tuberculosis (TB) disease has been well recognized. Over 100 g...

Tuberculosis

33689

Participants

N/A

Studies

Details PubMed

GWAS 2023-07-18

Genetic insights into ossification of the posterior longitudinal ligament of the spine.

Koike Y

Elife

Ossification of the posterior longitudinal ligament of the spine

22016

Participants

N/A

Studies

Details PubMed

GWAS 2023-06-09

Native American genetic ancestry and pigmentation allele contributions to skin color in a Caribbean population.

Ang KC, Canfield VA et al.

Elife

Our interest in the genetic basis of skin color variation between populations led us to seek a Nativ...

Skin pigmentation

358

Participants

N/A

Studies

Details PubMed

GWAS 2023-05-25

A meta-analysis of genome-wide association studies of childhood wheezing phenotypes identifies ANXA1 as a susceptibility locus for persistent wheezing.

Granell R, Curtin JA et al.

Elife

Many genes associated with asthma explain only a fraction of its heritability. Most genome-wide asso...

Childhood wheezing (early-onset)

Replicated

8427

Participants

N/A

Studies

Details PubMed

GWAS 2023-03-28

Longitudinal fundus imaging and its genome-wide association analysis provide evidence for a human retinal aging clock.

Ahadi S, Wilson KA et al.

Elife

Biological age, distinct from an individual's chronological age, has been studied extensively throug...

Aging (eyeAgeAcceleration)

45444

Participants

N/A

Studies

Details PubMed

GWAS 2022-09-20

Diverse ancestry whole-genome sequencing association study identifies TBX5 and PTK7 as susceptibility genes for posterior urethral valves.

Chan MMY, Sadeghi-Alavijeh O et al.

Elife

Posterior urethral valves (PUV) are the commonest cause of end-stage renal disease in children, but ...

Posterior urethral valves

Replicated

23859

Participants

N/A

Studies

Details PubMed

GWAS 2022-09-08

Integrative analysis of metabolite GWAS illuminates the molecular basis of pleiotropy and genetic correlation.

Smith CJ, Sinnott-Armstrong N et al.

Elife

Pleiotropy and genetic correlation are widespread features in genome-wide association studies (GWAS)...

Glycine levels

94464

Participants

N/A

Studies

Details PubMed

GWAS 2022-07-22

BIRC6 modifies risk of invasive bacterial infection in Kenyan children.

Gilchrist JJ, Kariuki SN et al.

Elife

Invasive bacterial disease is a major cause of morbidity and mortality in African children. Despite ...

Invasive bacterial infection

5400

Participants

N/A

Studies

Details PubMed

GWAS 2022-01-13

GWAS and ExWAS of blood Mitochondrial DNA copy number identifies 71 loci and highlights a potential causal role in dementia.

Chong M, Mohammadi-Shemirani P et al.

Elife

Mitochondrial DNA copy number (mtDNA-CN) is an accessible blood-based measurement believed to captur...

Mitochondrial DNA copy number

395718

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

A mathematical model that predicts human biological age from physiological traits identifies environmental and genetic factors that influence aging.

Libert S, Chekholko A et al.

Elife

Biological age difference (delta-Age)

2025-06-11

Novel risk loci for COVID-19 hospitalization among admixed American populations.

Diz-de Almeida S, Cruz R et al.

Elife

COVID-19 (hospitalized covid vs population)

2024-10-03

Association of genetic variation in COL11A1 with adolescent idiopathic scoliosis.

Yu H, Khanshour AM et al.

Elife

Adolescent idiopathic scoliosis

2024-01-26

Multi-ancestry meta-analysis of host genetic susceptibility to tuberculosis identifies shared genetic architecture.

Schurz H, Naranbhai V et al.

Elife

Tuberculosis

2024-01-15

Genetic insights into ossification of the posterior longitudinal ligament of the spine.

Koike Y

Elife

Ossification of the posterior longitudinal ligament of the spine

2023-07-18

Native American genetic ancestry and pigmentation allele contributions to skin color in a Caribbean population.

Ang KC, Canfield VA et al.

Elife

Skin pigmentation

2023-06-09

A meta-analysis of genome-wide association studies of childhood wheezing phenotypes identifies ANXA1 as a susceptibility locus for persistent wheezing.

Granell R, Curtin JA et al.

Elife

Childhood wheezing (early-onset)

2023-05-25

Longitudinal fundus imaging and its genome-wide association analysis provide evidence for a human retinal aging clock.

Ahadi S, Wilson KA et al.

Elife

Aging (eyeAgeAcceleration)

2023-03-28

Diverse ancestry whole-genome sequencing association study identifies TBX5 and PTK7 as susceptibility genes for posterior urethral valves.

Chan MMY, Sadeghi-Alavijeh O et al.

Elife

Posterior urethral valves

2022-09-20

Integrative analysis of metabolite GWAS illuminates the molecular basis of pleiotropy and genetic correlation.

Smith CJ, Sinnott-Armstrong N et al.

Elife

Glycine levels

2022-09-08

BIRC6 modifies risk of invasive bacterial infection in Kenyan children.

Gilchrist JJ, Kariuki SN et al.

Elife

Invasive bacterial infection

2022-07-22

GWAS and ExWAS of blood Mitochondrial DNA copy number identifies 71 loci and highlights a potential causal role in dementia.

Chong M, Mohammadi-Shemirani P et al.

Elife

Mitochondrial DNA copy number

2022-01-13

Health & Traits Publications

A mathematical model that predicts human biological age from physiological traits identifies environmental and genetic factors that influence aging.

Novel risk loci for COVID-19 hospitalization among admixed American populations.

Association of genetic variation in <i>COL11A1</i> with adolescent idiopathic scoliosis.

Multi-ancestry meta-analysis of host genetic susceptibility to tuberculosis identifies shared genetic architecture.

Genetic insights into ossification of the posterior longitudinal ligament of the spine.

Native American genetic ancestry and pigmentation allele contributions to skin color in a Caribbean population.

A meta-analysis of genome-wide association studies of childhood wheezing phenotypes identifies <i>ANXA1</i> as a susceptibility locus for persistent wheezing.

Longitudinal fundus imaging and its genome-wide association analysis provide evidence for a human retinal aging clock.

Diverse ancestry whole-genome sequencing association study identifies <i>TBX5</i> and <i>PTK7</i> as susceptibility genes for posterior urethral valves.

Integrative analysis of metabolite GWAS illuminates the molecular basis of pleiotropy and genetic correlation.

BIRC6 modifies risk of invasive bacterial infection in Kenyan children.

GWAS and ExWAS of blood Mitochondrial DNA copy number identifies 71 loci and highlights a potential causal role in dementia.