A meta-analysis of genome-wide association studies of childhood wheezing phenotypes identifies <i>ANXA1</i> as a susceptibility locus for persistent wheezing.
Granell R, Curtin JA, Haider S et al.
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Abstract
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Many genes associated with asthma explain only a fraction of its heritability. Most genome-wide association studies (GWASs) used a broad definition of 'doctor-diagnosed asthma', thereby diluting genetic signals by not considering asthma heterogeneity. The objective of our study was to identify genetic associates of childhood wheezing phenotypes.
943 European ancestry cases, 5,887 European ancestry controls
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