Active: HDL cholesterol Clear all

GWAS 2025-09-26

Genetic impact of central adiposity on systolic blood pressure in females: interaction and mediation by TG/HDL-C, HbA1c, and uric acid across BMI categories.

Gumilang RA, Bai CH

Int J Obes (Lond)

Genetic predisposition to central adiposity is associated with metabolic dysfunction and obesity-rel...

Waist circumference

49188

Participants

N/A

Studies

Details PubMed

GWAS 2025-04-11

Large-scale multi-omics analyses in Hispanic/Latino populations identify genes for cardiometabolic traits.

Petty LE, Chen HH et al.

Nat Commun

Here, we present a multi-omics study of type 2 diabetes and quantitative blood lipid and lipoprotein...

Type 2 diabetes

60975

Participants

N/A

Studies

Details PubMed

GWAS 2024-09-14

Genome-wide discovery and integrative genomic characterization of insulin resistance loci using serum triglycerides to HDL-cholesterol ratio as a proxy.

DeForest N, Wang Y et al.

Nat Commun

Insulin resistance causes multiple epidemic metabolic diseases, including type 2 diabetes, cardiovas...

Triglyceride to HDL cholesterol ratio

Replicated

419674

Participants

N/A

Studies

Details PubMed

GWAS 2024-01-10

Comprehensive genetic study of the insulin resistance marker TG:HDL-C in the UK Biobank.

Oliveri A, Rebernick RJ et al.

Nat Genet

Insulin resistance (IR) is a well-established risk factor for metabolic disease. The ratio of trigly...

Triglyceride to HDL cholesterol ratio

402398

Participants

N/A

Studies

Details PubMed

GWAS 2023-07-04

Association of non-high-density lipoprotein cholesterol trajectories with the development of non-alcoholic fatty liver disease: an epidemiological and genome-wide association study.

Lee JH, Kim J et al.

J Transl Med

Non-alcoholic fatty liver disease (NAFLD) shares common risk factors with cardiovascular diseases. E...

Nonalcoholic fatty liver disease

2203

Participants

N/A

Studies

Details PubMed

GWAS 2021-08-18

Genome-wide Association Study of Lipid Traits in Youth With Type 2 Diabetes.

Santoro N, Chen L et al.

J Endocr Soc

Context: Dyslipidemia is highly prevalent in youth with type 2 diabetes (T2D), yet the pathogenic co...

HDL cholesterol levels in type 2 diabetes

1037

Participants

N/A

Studies

Details PubMed

GWAS 2021-07-08

Genome-Wide Association Study Identifies a Functional <i>SIDT2</i> Variant Associated With HDL-C (High-Density Lipoprotein Cholesterol) Levels and Premature Coronary Artery Disease.

León-Mimila P, Villamil-Ramírez H et al.

Arterioscler Thromb Vasc Biol

Objective: Low HDL-C (high-density lipoprotein cholesterol) is the most frequent dyslipidemia in Mex...

HDL cholesterol levels

Replicated

4751

Participants

N/A

Studies

Details PubMed

GWAS 2021-06-17

A unified framework identifies new links between plasma lipids and diseases from electronic medical records across large-scale cohorts.

Veturi Y, Lucas A et al.

Nat Genet

Plasma lipids are known heritable risk factors for cardiovascular disease, but increasing evidence a...

HDL cholesterol levels

31565

Participants

N/A

Studies

Details PubMed

GWAS 2020-08-05

Genome-wide association studies in Samoans give insight into the genetic architecture of fasting serum lipid levels.

Carlson JC, Weeks DE et al.

J Hum Genet

The current understanding of the genetic architecture of lipids has largely come from genome-wide as...

HDL cholesterol levels

Replicated

4647

Participants

N/A

Studies

Details PubMed

GWAS 2020-02-14

Gene discovery for high-density lipoprotein cholesterol level change over time in prospective family studies.

Feitosa MF, Lunetta KL et al.

Atherosclerosis

Backgrounds and aims: Several genes are known to contribute to the levels and metabolism of HDL-C, h...

HDL cholesterol levels

7738

Participants

N/A

Studies

Details PubMed

GWAS 2019-11-06

The interaction between ABCA1 polymorphism and physical activity on the HDL-cholesterol levels in a Japanese population.

Nishida Y, Hachiya T et al.

J Lipid Res

Few studies have investigated the interactions between HDL-C-related SNPs identified by genome-wide ...

HDL cholesterol levels

Replicated

4830

Participants

N/A

Studies

Details PubMed

GWAS 2019-04-04

Protein and fat intake interacts with the haplotype of PTPN11_rs11066325, RPH3A_rs886477, and OAS3_rs2072134 to modulate serum HDL concentrations in middle-aged people.

Liu M, Jin HS et al.

Clin Nutr

Background & aims: Low serum HDL cholesterol (HDL-C) concentration is a risk factor for cardiova...

Low HDL-cholesterol levels

8839

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genetic impact of central adiposity on systolic blood pressure in females: interaction and mediation by TG/HDL-C, HbA1c, and uric acid across BMI categories.

Gumilang RA, Bai CH

Int J Obes (Lond)

Waist circumference

2025-09-26

Large-scale multi-omics analyses in Hispanic/Latino populations identify genes for cardiometabolic traits.

Petty LE, Chen HH et al.

Nat Commun

Type 2 diabetes

2025-04-11

Genome-wide discovery and integrative genomic characterization of insulin resistance loci using serum triglycerides to HDL-cholesterol ratio as a proxy.

DeForest N, Wang Y et al.

Nat Commun

Triglyceride to HDL cholesterol ratio

2024-09-14

Comprehensive genetic study of the insulin resistance marker TG:HDL-C in the UK Biobank.

Oliveri A, Rebernick RJ et al.

Nat Genet

Triglyceride to HDL cholesterol ratio

2024-01-10

Association of non-high-density lipoprotein cholesterol trajectories with the development of non-alcoholic fatty liver disease: an epidemiological and genome-wide association study.

Lee JH, Kim J et al.

J Transl Med

Nonalcoholic fatty liver disease

2023-07-04

Genome-wide Association Study of Lipid Traits in Youth With Type 2 Diabetes.

Santoro N, Chen L et al.

J Endocr Soc

HDL cholesterol levels in type 2 diabetes

2021-08-18

Genome-Wide Association Study Identifies a Functional <i>SIDT2</i> Variant Associated With HDL-C (High-Density Lipoprotein Cholesterol) Levels and Premature Coronary Artery Disease.

León-Mimila P, Villamil-Ramírez H et al.

Arterioscler Thromb Vasc Biol

HDL cholesterol levels

2021-07-08

A unified framework identifies new links between plasma lipids and diseases from electronic medical records across large-scale cohorts.

Veturi Y, Lucas A et al.

Nat Genet

HDL cholesterol levels

2021-06-17

Genome-wide association studies in Samoans give insight into the genetic architecture of fasting serum lipid levels.

Carlson JC, Weeks DE et al.

J Hum Genet

HDL cholesterol levels

2020-08-05

Gene discovery for high-density lipoprotein cholesterol level change over time in prospective family studies.

Feitosa MF, Lunetta KL et al.

Atherosclerosis

HDL cholesterol levels

2020-02-14

The interaction between ABCA1 polymorphism and physical activity on the HDL-cholesterol levels in a Japanese population.

Nishida Y, Hachiya T et al.

J Lipid Res

HDL cholesterol levels

2019-11-06

Protein and fat intake interacts with the haplotype of PTPN11_rs11066325, RPH3A_rs886477, and OAS3_rs2072134 to modulate serum HDL concentrations in middle-aged people.

Liu M, Jin HS et al.

Clin Nutr

Low HDL-cholesterol levels

2019-04-04